Cancer as a system failure

Cancer Informatics

Volumn 5, Issue , 2007, Pages 10-18

  Wigle, Dennis ^a   Jurisica, Igor ^b  

^a MAYO CLINIC CANCER CENTER   (United States)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; ERLOTINIB; GEFITINIB; PLATINUM DERIVATIVE;

ANGIOGENESIS; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER GENETICS; CANCER SURGERY; CLINICAL TRIAL; DNA DAMAGE; DNA REPAIR; EDITORIAL; GENE MUTATION; HUMAN; LUNG NON SMALL CELL CANCER; MATHEMATICAL MODEL; PHARMACOGENETICS; PROTEIN DNA INTERACTION; SIGNAL TRANSDUCTION; SOLID TUMOR; SYSTEMS BIOLOGY; TUMOR GENE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CENTRAL NERVOUS SYSTEM CANCER; CHROMOSOME ABERRATION; COLON CANCER; EPIGENETICS; GENETIC STABILITY; MALIGNANT TRANSFORMATION; MEDICAL INFORMATICS; METASTASIS; NON SMALL CELL LUNG CANCER; NONHUMAN; PROSTATE CANCER; SOLID MALIGNANT NEOPLASM; TUMOR INVASION;

EID: 49649110339     PISSN: 11769351     EISSN: 11769351     Source Type: Journal    
DOI: 10.1177/117693510700500003     Document Type: Editorial

References (25)

1. Alberghina, L., F. Chiaradonna, et al. (2004). Systems biology and the molecular circuits of cancer. Chem. Bio. Chem., 5(10):1322-1333.
2. Blackhall, F., M. Ranson, et al. (2006). Where next for gefitinib in patients with lung cancer? Lancet, Oncology, 7(6):499-507.
3. Brown, K.R. and I. Jurisica (2005). Online predicted human interaction database. Bioinformatics, 21(9):2076-82.
4. Cleaver, J. (2005). Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat. Rev. Cancer, 5(7):564-73.
5. Folkman, J. (1990). What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer, Inst., 82(1):4-6.
6. Futreal, P., L. Coin, et al. (2004). A census of human cancer genes. Nature Reviews Cancer, 4(3):177-183.
7. Gazdar, A. (2007). DNA repair and survival in lung cancer - The two faces of janus. NEJM, 356:771.
8. Hanahan, D. and R. Weinberg (2000). The hallmarks of cancer. Cell, 100(1):57-70.
9. Hornberg, J., F. Bruggeman, et al. (2006). Cancer: A systems biology disease. Biosystems, 83(2-3): 81-90.
10. Hu, P., G. Bader, et al. (2007). Computational prediction of cancer-gene function. Nat. Rev. Cancer, 7(1):23-34.
11. Johnson, B. E. and P. A. Janne (2005). Epidermal growth factor receptor mutations in patients with non-small cell lung cancer. Cancer, Res., 65(17):7525-9.
12. Kafatos, F. and T. Eisner (2004). Unification in the Century of Biology.
13. Khalil, I. and C. Hill (2005). Systems biology for cancer. Curr. Opin. Oncol., 17(1):44-48.
14. Kitano, H. (2002). Systems biology: a brief overview. Science, 295(5560):1662-4.
15. Le Novere, N., B. Bornstein, et al. (2006). Biomodels database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems. Nucleic Acids Res., 34(Database issue):D689-91.
16. Lynch, T., D. Bell, et al. (2004). Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung Cancer to Gefitinib.
17. Maslov, S. and K. Sneppen (2002). Specificity and stability in topology of protein networks. Science 296(5569):910-3.
18. Oda, K., Y. Matsuoka, et al. (2005). A comprehensive pathway map of epidermal growth factor receptor signaling. Mol. Syst. Biol., 1:2005 0010.
19. Olaussen, K., A. Dunant, et al. (2006). DNA repair by ERCC 1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. The New England journal of medicine, 355(10):983-991.
20. Paez, J., P. Janne, et al. (2004). EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy, American Association for the Advancement of Science.
21. Pawson, T. and N. Warner (2007). Oncogenic re-wiring of cellular signaling pathways. Oncogene 26(9):1268-75.
22. Spencer, S., M. Berryman, et al. (2004). "An ordinary differential equation model for the multistep transformation to cancer. Arxiv preprint q-bio. CB/0403006.
23. Strausberg, R., A. Simpson, et al. (2003). Sequence-based cancer genomics: progress, lessons and opportunities. Nature Reviews Genetics, 4(6):409-418.
24. Zheng, Z., T. Chen, et al. (2007). DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. NEJM, 356:800.
25. Zhou, B. and S. Elledge (2000). The DNA damage response: putting checkpoints in perspective." Nature, 408(6811):433-439.