Folding propensity and biological activity of peptides: The effect of a single stereochemical isomerization on the conformational properties of bombinins in aqueous solution

Biopolymers

Volumn 89, Issue 9, 2008, Pages 769-778

  Bozzi, Argante ^a   Mangoni, Maria Luisa ^b   Rinaldi, Andrea C ^c   Mignogna, Giuseppina ^b   Aschi, Massimiliano ^d  

^a Università L'Aquila e Consorzlo INBB   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

^d UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Antimicrobial peptides; Circular dichroism; Free energy; Frog skin; Molecular dynamics (MD)

Indexed keywords

BIOACTIVITY; DICHROISM; DYNAMICS; ELECTRON TRANSITIONS; ISOMERIZATION; ISOMERS; MOLECULAR DYNAMICS; OPTICAL PROPERTIES; PEPTIDES; PROTEINS; QUANTUM CHEMISTRY; SOLUTIONS;

ANTIMICROBIAL PEPTIDES; AQUEOUS SOLUTIONS; BIOLOGICAL ACTIVITIES; CD MEASUREMENTS; CIRCULAR DICHROISM; CONFORMATIONAL PROPERTIES; ENTROPIC EFFECTS; FREE ENERGY; FROG SKIN; HELICAL PEPTIDES; L-ISOLEUCINE; MD SIMULATIONS; MD TRAJECTORIES; MOLECULAR DYNAMICS (MD); MOLECULAR-DYNAMICS SIMULATIONS; PRELIMINARY INFORMATION; PRIMARY STRUCTURES;

AMINES;

ALLOISOLEUCINE; BOMBININ; BOMBININ H2; BOMBININ H4; ISOLEUCINE; PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; WATER; AMPHIBIAN PROTEIN; ANTIMICROBIAL CATIONIC PEPTIDE;

AMINO ACID SEQUENCE; AQUEOUS SOLUTION; ARTICLE; BIOLOGICAL ACTIVITY; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG STRUCTURE; ENTROPY; ISOMERIZATION; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; PROTEIN CONFORMATION; PROTEIN FOLDING; RESIDUE ANALYSIS; SEQUENCE ANALYSIS; SIMULATION; STEREOCHEMISTRY; STRUCTURE ANALYSIS; CELL MEMBRANE; CHEMISTRY; COMPUTER SIMULATION;

AMPHIBIA; ANURA;

AMPHIBIAN PROTEINS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL MEMBRANE; CIRCULAR DICHROISM; COMPUTER SIMULATION; ENTROPY; PROTEIN FOLDING;

EID: 49649110165     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21006     Document Type: Article

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