Histopathology of myocarditis

Diagnostic Histopathology

Volumn 14, Issue 8, 2008, Pages 401-407

  Chimenti, Cristina ^a   Frustaci, Andrea ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

histology; immunohistochemistry; molecular biology; myocarditis

Indexed keywords

BETA1 INTEGRIN; BLOOD CLOTTING FACTOR 8; CD20 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD45RO ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; HLA ANTIGEN; HLA DR3 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; LEUKOSIALIN; MAJOR BASIC PROTEIN; PERFORIN; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CAUSAL ATTRIBUTION; HEART ARRHYTHMIA; HEART FAILURE; HEART MUSCLE BIOPSY; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; ISCHEMIA; MOLECULAR BIOLOGY; MYOCARDITIS; POLYMERASE CHAIN REACTION; PROGNOSIS; VIRUS GENOME;

EID: 49649095933     PISSN: 17562317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mpdhp.2008.06.012     Document Type: Article

References (53)

1. Richardson P., McKenna W., Bristow M., et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation 93 (1996) 841-842
2. Parrillo J.E., Aretz H.T., Palacios I., et al. The results of transvenous endomyocardial biopsy can frequently be used to diagnose myocardial diseases in patients with idiopathic heart failure: endomyocardial biopsies in 100 consecutive patients revealed a substantial incidence of myocarditis. Circulation 69 (1984) 93-101
3. Martino T.A., Liu P., Petric M., and Sole M.J. Enteroviral myocarditis and dilated cardiomyopathy; a review of clinical and experimental studies. In: Rotbart H.A. (Ed). Human enteroviral infections (1995), ASM Press, Washington, DC 291-351
4. Maron B.J., Towbin J.A., Thiene G., et al. Contemporary definitions and classification of the cardiomyopathies: an American heart association scientific statement from the council on clinical cardiology, heart failure and transplantation committee; quality of care and outcomes research and functional genomics and translational biology interdisciplinary working groups; and council on epidemiology and prevention. Circulation 113 (2006) 1807-1816
5. Cooper L.T., Baughman K.L., Feldman A.M., et al. The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American heart association, the American college of cardiology, and the European Society of Cardiology. Circulation 116 (2007) 2216-2233
6. Mahrholdt H., Goedecke C., Wagner A., et al. Cardiovascular magnetic resonance assessment of human myocarditis: a comparison to histology and molecular pathology. Circulation 109 (2004) 1250-1258
7. Aretz H., Billingham M.E., Edwards W.D., et al. Myocarditis: a histopathologic definition and classification. Am J Cardiovasc Pathol 1 (1986) 3-14
8. Chow L.H., Radio S.J., Sears T.D., and McManus B.M. Insensitivity of right ventricular endomyocardial biopsy in the diagnosis of myocarditis. J Am Coll Cardiol 14 (1989) 915-920
9. Hauck A.J., Kearney D.L., and Edwards W.D. Evaluation of postmortem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: implications for role of sampling error. Mayo Clin Proc 64 (1989) 1235-1245
10. Burke A.P., Farb A., Robinowitz M., and Virmani R. Serial sectioning and multiple level examination of endomyocardial biopsies for the diagnosis of myocarditis. Mod Pathol 4 (1991) 690-693
11. Frustaci A., Bellocci F., and Olsen E.G. Results of biventricular endomyocardial biopsy in survivors of cardiac arrest with apparently normal hearts. Am J Cardiol 74 (1994) 890-895
12. Frustaci A., Pieroni M., and Chimenti C. The role of endomyocardial biopsy in the diagnosis of cardiomyopathies. Ital Heart J 3 (2002) 348-353
13. Baughman K.L. Diagnosis of myocarditis: death of Dallas criteria. Circulation 113 (2006) 593-595
14. Shanes J.G., Ghali J., Billingham M.E., et al. Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation 75 (1987) 401-405
15. Mason J.W., O'Connell J.B., Herskowitz A., et al. A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. N Engl J Med 333 (1995) 269-275
16. Angelini A., Crosato M., and Boffa G.M. Active versus borderline myocarditis: clinicopathological correlates and prognostic implications. Heart 87 (2002) 210-215
17. Edwards W.D., Holmes Jr. D.R., and Reeder G.S. Diagnosis of active lymphocytic myocarditis by endomyocardial biopsy: quantitative criteria for light microscopy. Mayo Clin Proc 57 (1982) 419-425
18. Maisch B., Richter A., Sandmöller A., Portig I., Pankuweit S., and Bmbf-Heart Failure Network. Inflammatory dilated cardiomyopathy (DCMI). Herz 30 (2005) 535-544
19. Kuhl U., Seeberg B., Schultheiss H.P., and Strauer B.E. Immunohistological characterization of infiltrating lymphocytes in biopsies of patients with clinically suspected dilated cardiomyopathy. Eur Heart J 15 Suppl C (1994) 62-67
20. deMello D.E., Liapis H., Jureidini S., Nouri S., Kephart G.M., and Gleich G.J. Cardiac localization of eosinophil-granule major basic protein in acute necrotizing myocarditis. N Engl J Med 323 (1990) 1542-1545
21. Calabrese F., Angelini A., Carturan E., and Thiene G. Myocarditis and inflammatory cardiomyopathy: histomorphological diagnosis. Ernst Schering Res Found Workshop 55 (2006) 305-321
22. Li Y., Bourlet T., Andreoletti L., et al. Enteroviral capsid protein VP1 is present in myocardial tissues from some patients with myocarditis or dilated cardiomyopathy. Circulation 101 (2000) 231-234
23. Frustaci A., Calabrese F., Chimenti C., Pieroni M., Thiene G., and Maseri A. Lone hepatitis C virus myocarditis responsive to immunosuppressive therapy. Chest 122 (2002) 1348-1356
24. Chimenti C., Russo A., Pieroni M., et al. Intramyocyte detection of Epstein-Barr virus genome by laser capture microdissection in patients with inflammatory cardiomyopathy. Circulation 110 (2004) 3534-3539
25. Noutsias M., Fechner H., de Jonge H., et al. Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. Circulation 104 (2001) 275-280
26. Leong A.S. Pitfall in diagnostic immunohistology. Adv Anat Pathol 11 (2004) 86-93
27. Chimenti C., Pieroni M., and Russo A. Laser microdissection in clinical cardiovascular research. Chest 128 (2005) 2876-2881
28. Pauschinger M., Doerner A., Kuehl U., et al. Enteroviral RNA replication in the myocardium of patients with left ventricular dysfunction and clinically suspected myocarditis. Circulation 99 (1999) 889-895
29. Kuhl U., Pauschinger M., Seeberg B., et al. Viral persistence in the myocardium is associated with progressive cardiac dysfunction. Circulation 112 (2005) 1965-1970
30. Xiong D., Lee G.H., Badorff C., et al. Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease. Nat Med 8 (2002) 872-877
31. Bowles N.E., Ni J., Kearney D.L., et al. Detection of viruses in myocardial tissues by polymerase chain reaction. Evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol 42 (2003) 466-472
32. Tschope C., Bock C.T., Kasner M., et al. High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction. Circulation 111 (2005) 879-886
33. Kühl U., Pauschinger M., and Noutsias M. High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction. Circulation 111 (2005) 887-893
34. Muir P., Ras A., Klapper P.E., et al. Multicenter quality assessment of PCR methods for detection of enteroviruses. J Clin Microbiol 37 (1999) 1409-1414
35. Borst A., Box A.T., and Fluit A.C. False-positive results and contamination in nucleic acid amplification assays: suggestions for a prevent and destroy strategy. Eur J Clin Microbiol Infect Dis 23 (2004) 289-299
36. Kuhl U., Pauschinger M., Schwimmbeck P.L., et al. Interferon-beta treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction. Circulation 107 (2003) 2793-2798
37. Frustaci A., Chimenti C., Calabrese F., Pieroni M., Thiene G., and Maseri A. Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders. Circulation 107 (2003) 857-863
38. Chimenti C., Calabrese F., Thiene G., Pieroni M., Maseri A., and Frustaci A. Inflammatory left ventricular microaneurysms as a cause of apparently idiopathic ventricular tachyarrhythmias. Circulation 104 (2001) 168-173
39. Kühl U., Noutsias M., Seeberg B., and Schultheiss H.P. Immunohistological evidence for a chronic intramyocardial inflammatory process in dilated cardiomyopathy. Heart 75 (1996 Mar) 295-300
40. Noutsias M., Pauschinger M., Schultheiss H.P., and Kühl U. Cytotoxic perforin+ and TIA-1+ infiltrates are associated with cell adhesion molecule expression in dilated cardiomyopathy. Eur J Heart Fail 5 (2003) 469-479
41. Angelini A., Crosato M., Boffa G.M., et al. Active versus borderline myocarditis: clinicopathological correlates and prognostic implications. Heart 87 (2002) 210-215
42. Rauch A.E., Amyot K.M., Dunn H.G., Ng B., and Wilner G. Hypereosinophilic syndrome and myocardial infarction in a 15-year-old. Pediatr Pathol Lab Med 17 (1997) 469-486
43. Wojnicz R., Nowalany-Kozielska E., Wodniecki J., et al. Immunohistological diagnosis of myocarditis. Potential role of sarcolemmal induction of the MHC and ICAM-1 in the detection of autoimmune mediated myocyte injury. Eur Heart J 19 (1998) 1564-1572
44. Noutsias M., Seeberg B., Schultheiss H.P., and Kühl U. Expression of cell adhesion molecules in dilated cardiomyopathy: evidence for endothelial activation in inflammatory cardiomyopathy. Circulation 99 (1999) 2124-2131
45. Martin A.B., Webber S., Fricker F.J., et al. Acute myocarditis. Rapid diagnosis by PCR in children. Circulation 90 (1994) 330-339
46. Baboonian C., and Treasure T. Meta-analysis of the association of enteroviruses with human heart disease. Heart 78 (1997) 539-543
47. Pauschinger M., Bowles N.E., Fuentes-Garcia F.J., et al. Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction. Circulation 99 (1999) 1348-1354
48. Calabrese F., Rigo E., Milanesi O., et al. Molecular diagnosis of myocarditis and dilated cardiomyopathy in children: clinicopathologic features and prognostic implications. Diagn Mol Pathol 11 (2002) 212-221
49. Frustaci A., Chimenti C., Calabrese F., Pieroni M., Thiene G., and Maseri A. Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders. Circulation 107 (2003) 857-863
50. Chimenti C., Russo A., Pieroni M., Calabrese F., Verardo R., Thiene G., Russo M.A., Maseri A., and Frustaci A. Intramyocyte Detection of Epstein Barr Virus Genome by Laser Capture Microdissection in Patients With Inflammatory Cardiomyopathy. Circulation 110 (2004) 3534-3539
51. Bowles N.E., Ni J., Kearney D.L., et al. Detection of viruses in myocardial tissues by polymerase chain reaction. evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol 42 (2003) 466-472
52. Kuhl U., Pauschinger M., Seeberg B., et al. Viral persistence in the myocardium is associated with progressive cardiac dysfunction. Circulation 112 (2005) 1965-1970
53. Caforio A.L., Calabrese F., Angelini A., et al. A prospective study of biopsy-proven myocarditis: prognostic relevance of clinical and aetiopathogenetic features at diagnosis. Eur Heart J 28 (2007) 1326-1333