Investigation of CD69 as a new candidate gene for rheumatoid arthritis

Tissue Antigens

Volumn 72, Issue 3, 2008, Pages 206-210

  Rueda, B ^a   Fernandez Gutierrez, B ^b   Balsa, A ^c   Pacual Salcedo, D ^c   Lamas, J R ^b   Raya, E ^d   Gonzalez Gay, M A ^e   Martin, J ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

^e HOSPITAL XERAL CALDE   (Spain)

Author keywords

Association study; CD69; Haplotype; Polymorphisms; Rheumatoid arthritis

Indexed keywords

CD69 ANTIGEN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ADULT; AGED; ALLELE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

AGED; ALLELES; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 49649089269     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2008.01094.x     Document Type: Article

References (26)

1. Cope AP, Schulze-Koops H, Aringer M. The central role of T cells in rheumatoid arthritis. Clin Exp Rheumatol 2007 : 25 (Suppl 46 S4 11.
2. Orozco G, Rueda B, Martin J. Genetic basis of rheumatoid arthritis. Biomed Pharmacother 2006 : 60 : 656 62.
3. Gregersen PK. Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond. Immunol Rev 2005 : 204 : 74 86.
4. Park SH, Min DJ, Cho ML et al. Shift toward T helper 1 cytokines by type II collagen-reactive T cells in patients with rheumatoid arthritis. Arthritis Rheum 2001 : 44 : 561 9.
5. Ronnelid J, Berg L, Rogberg S et al. Production of T-cell cytokines at the single-cell level in patients with inflammatory arthritides: enhanced activity in synovial fluid compared to blood. Br J Rheumatol 1998 : 37 : 7 14.
6. Hara T, Jung LK, Bjorndahl JM, Fu SM. Human T cell activation. III. Rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA 1) by 12-o-tetradecanoyl phorbol-13-acetate, mitogens, and antigens. J Exp Med 1986 : 164 : 1988 2005.
7. Ziegler SF, Ramsdell F, Hjerrild KA et al. Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. Eur J Immunol 1993 : 23 : 1643 8.
8. Sanchez-Mateos P, Cebrian M, Acevedo A, Lopez-Botet M, De Landazuri MO, Sanchez-Madrid F. Expression of a gp33/27,000 MW activation inducer molecule (AIM) on human lymphoid tissues. Induction of cell proliferation on thymocytes and B lymphocytes by anti-AIM antibodies. Immunology 1989 : 68 : 72 9.
9. Garcia-Monzon C, Moreno-Otero R, Pajares JM et al. Expression of a novel activation antigen on intrahepatic CD8+ T lymphocytes in viral chronic active hepatitis. Gastroenterology 1990 : 98 : 1029 35.
10. Laffon A, Garcia-Vicuna R, Humbria A et al. Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis. J Clin Invest 1991 : 88 : 546 52.
11. Sancho D, Gomez M, Sanchez-Madrid F. CD69 is an immunoregulatory molecule induced following activation. Trends Immunol 2005 : 26 : 136 40.
12. Afeltra A, Galeazzi M, Ferri GM et al. Expression of CD69 antigen on synovial fluid T cells in patients with rheumatoid arthritis and other chronic synovitis. Ann Rheum Dis 1993 : 52 : 457 60.
13. Atzeni F, Del Papa N, Sarzi-Puttini P, Bertolazzi F, Minonzio F, Capsoni F. CD69 expression on neutrophils from patients with rheumatoid arthritis. Clin Exp Rheumatol 2004 : 22 : 331 4.
14. Fernandez-Gutierrez B, Hernandez-Garcia C, Banares AA, Jover JA. Characterization and regulation of CD69 expression on rheumatoid arthritis synovial fluid T cells. J Rheumatol 1995 : 22 : 413 20.
15. Hernandez-Garcia C, Fernandez-Gutierrez B, Morado IC, Banares AA, Jover JA. The CD69 activation pathway in rheumatoid arthritis synovial fluid T cells. Arthritis Rheum 1996 : 39 : 1277 86.
16. Sancho D, Gomez M, Viedma F et al. CD69 downregulates autoimmune reactivity through active transforming growth factor-beta production in collagen-induced arthritis. J Clin Invest 2003 : 112 : 872 82.
17. The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007 : 447 : 661 78.
18. Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988 : 31 : 315 24.
19. Lee HS, Remmers EF, Le JM, Kastner DL, Bae SC, Gregersen PK. Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med 2007 : 13 : 455 60.
20. Remmers EF, Plenge RM, Lee AT et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 2007 : 357 : 977 86.
21. Orozco G, Sanchez E, Gonzalez-Gay MA et al. Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum 2005 : 52 : 219 24.
22. Orozco G, Alizadeh B, Delgado-Vega A et al. Association of STAT4 gene with rheumatoid arthritis: a replication study in three European populations. Arthritis Rheum 2008 : 58 : 1974 80.
23. Buckland PR. The importance and identification of regulatory polymorphisms and their mechanisms of action. Biochim Biophys Acta 2006 : 1762 : 17 28.
24. Wang X, Tomso DJ, Liu X, Bell DA. Single nucleotide polymorphism in transcriptional regulatory regions and expression of environmentally responsive genes. Toxicol Appl Pharmacol 2005 : 207 (Suppl 84 90.
25. Ishikawa S, Akakura S, Abe M et al. A subset of CD4+ T cells expressing early activation antigen CD69 in murine lupus: possible abnormal regulatory role for cytokine imbalance. J Immunol 1998 : 161 : 1267 73.
26. Shiow LR, Rosen DB, Brdickova N et al. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 2006 : 440 : 540 4.