Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: A report of 16 cases

International Journal of Gynecological Pathology

Volumn 27, Issue 3, 2008, Pages 366-379

  Khunamornpong, Surapan ^a   Lerwill, Melinda F ^b   Siriaunkgul, Sumalee ^a   Suprasert, Prapaporn ^a   Pojchamarnwiputh, Suwalee ^a   Chiangmai, Wittanee Na ^a   Young, Robert H ^b  

^a Faculty of Medicine Chiang Mai University   (Thailand)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cholangiocarcinoma; Extrahepatic bile duct carcinoma; Gallbladder carcinoma; Krukenberg tumor; Metastasis; Ovary

Indexed keywords

CYTOKERATIN;

ADULT; AGED; ARTICLE; BENIGN TUMOR; BILE DUCT CARCINOMA; CANCER INFILTRATION; CANCER INVASION; CELL HETEROGENEITY; CLINICAL ARTICLE; CLINICAL FEATURE; COLLOID CARCINOMA; CYSTADENOMA; DIFFERENTIAL DIAGNOSIS; ENDOMETRIUM CARCINOMA; FEMALE; GALLBLADDER CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALIGNANT NEOPLASTIC DISEASE; MICROSCOPY; MIXED TUMOR; MUCINOUS CARCINOMA; OVARY CARCINOMA; OVARY CYST; OVARY METASTASIS; OVARY TUMOR; PAPILLARY CARCINOMA; POSTOPERATIVE PERIOD; PRIMARY TUMOR; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VOLUME; UNDIFFERENTIATED CARCINOMA; ADENOCARCINOMA; BILE DUCT TUMOR; GALLBLADDER TUMOR; HEPATIC DUCT; METASTASIS; MIDDLE AGED; PATHOLOGY; RETROSPECTIVE STUDY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BILE DUCT NEOPLASMS; BILE DUCTS, EXTRAHEPATIC; CHOLANGIOCARCINOMA; FEMALE; GALLBLADDER NEOPLASMS; HUMANS; MIDDLE AGED; OVARIAN NEOPLASMS; RETROSPECTIVE STUDIES;

EID: 49549125489     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/PGP.0b013e31815d6903     Document Type: Article

References (38)

1. Young RH, Scully RE. Ovarian metastases from carcinoma of the gallbladder and extrahepatic bile ducts simulating primary tumors of the ovary. A report of six cases. Int J Gynecol Pathol 1990;9:60-72.
2. Schlagenhaufer F. Uber das metastatische Ovarialcarcinom mach Krebs des Magen Darmes und anderer Bauchorgane. Monatsschr Geburtshilfe Gynaekol 1902;15:485-528.
3. Willis RA. The Spread of Tumors in the Human Body. London: Butterworth; 1952:220-221
4. Lashgari M, Behmaram B, Hoffman JS, et al. Primary biliary carcinoma with metastasis to the ovary. Gynecol Oncol 1992;47:272-274 (Pubitemid 23001342)
5. Sharma P, Jaffe PE, Bhattacharyya A. Metastatic cholangiocarcinoma presenting as ovarian cancer: a rare Krukenberg tumor. Am J Gastroenterol 1997;92:531-533 (Pubitemid 27108204)
6. Kim KH, Kim CD, Lee HS, et al. Bilateral ovarian carcinoma metastatic from the ampulla of Vater: a rare Krukenberg tumor. J Korean Med Sci 1999;14:220-222
7. Ayhan A, Guney I, Saygan-Karamursel B, et al. Ovarian metastasis of primary biliary and gallbladder carcinomas. Eur J Gynaecol Oncol 2001;22:377-378 (Pubitemid 33144549)
8. Miyagui T, Luchemback L, Teixeira GH, et al. Meningeal carcinomatosis as the initial manifestation of a gallbladder adenocarcinoma associated with a Krukenberg tumor. Rev Hosp Clin Fac Med Sao Paulo 2003;58:169-172
9. Garcia A, De la Torre J, Castellvi J, et al. Ovarian metastases caused by cholangiocarcinoma: a rare Krukenberg's tumour simulating a primary neoplasm of the ovary: a two-case study. Arch Gynecol Obstet 2004;270:281-284
10. Jain V, Gupta K, Kudva R, et al. A case of ovarian metastasis of gall bladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature. Int J Gynecol Cancer 2006;16(suppl 1):319-321
11. Jarvi K, Kelty CJ, Thomas WE, et al. Bilateral ovarian metastases from carcinoma of the gallbladder. Gynecol Oncol 2006;103:361-362 (Pubitemid 44374712)
12. Taranto AJ, Lourie R, Lau WF. Ovarian vascular pedicle sign in ovarian metastasis arising from gall bladder carcinoma. Australas Radiol 2006;50:504-506 (Pubitemid 44386521)
13. Khunamornpong S, Siriaunkgul S, Suprasert P, et al. Intrahepatic cholangiocarcinoma metastatic to the ovary: a report of 16 cases of an underemphasized form of secondary tumor in the ovary that may mimic primary neoplasia. Am J Surg Pathol In press.
14. Khunamornpong S, Suprasert P, Na Chiangmai W, et al. Metastatic tumors to the ovaries: a study of 170 cases in northern Thailand. Int J Gynecol Cancer 2006;16(suppl 1):132-138
15. Khunamornpong S, Suprasert P, Pojchamarnwiputh S, et al. Primary and metastatic mucinous adenocarcinomas of the ovary: evaluation of the diagnostic approach using tumor size and laterality. Gynecol Oncol 2006;101:152-157 (Pubitemid 43303576)
16. Lee KR, Scully RE. Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with 'pseudomyxoma peritonei'. Am J Surg Pathol 2000;24:1447-1464
17. Lee KR, Young RH. The distinction between primary and metastatic mucinous carcinomas of the ovary: gross and histologic findings in 50 cases. Am J Surg Pathol 2003;27:281-292
18. Young RH, Scully RE. Differential diagnosis of ovarian tumors based primarily on their patterns and cell types. Semin Diagn Pathol 2001;18:161-235.
19. Riopel MA, Ronnett BM, Kurman RJ. Evaluation of diagnostic criteria and behavior of ovarian intestinal-type mucinous tumors: atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas. Am J Surg Pathol 1999;23:617-635
20. Albores-Saavedra J, Scoazec JC, Wittekind C, et al. Carcinoma of the gallbladder and extrahepatic bile ducts. In: Hamilton SR, Aaltonen LA, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System. Lyon: IARC Press; 2000:206-214
21. Nakanuma Y, Sripa B, Vatanasapt V, et al. Intrahepatic cholangiocarcinoma. In: Hamilton SR, Aaltonen LA, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System. Lyon: IARC Press; 2000:173-180
22. Young RH. From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary: part I. Historical perspective, general principles, mucinous tumors including the krukenberg tumor. Adv Anat Pathol 2006;13:205-227
23. Young RH. From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II. Adv Anat Pathol 2007;14:149-177
24. Ronnett BM, Zahn CM, Kurman RJ, et al. Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. A clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to "pseudomyxoma peritonei". Am J Surg Pathol 1995;19:1390-1408
25. Lash RH, Hart WR. Intestinal adenocarcinomas metastatic to the ovaries. A clinicopathologic evaluation of 22 cases. Am J Surg Pathol 1987;11:114-121
26. Kiyokawa T, Young RH, Scully RE. Krukenberg tumors of the ovary: a clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations. Am J Surg Pathol 2006;30:277-299 (Pubitemid 43740160)
27. Fujiwara K, Ohishi Y, Koike H, et al. Clinical implications of metastases to the ovary. Gynecol Oncol 1995;59:124-128
28. Seidman JD, Kurman RJ, Ronnett BM. Primary and metastatic mucinous adenocarcinomas in the ovaries: incidence in routine practice with a new approach to improve intraoperative diagnosis. Am J Surg Pathol 2003;27:985-993
29. Che M, Tornos C, Deavers MT, et al. Ovarian mixed-epithelial carcinomas with a microcystic pattern and signet-ring cells. Int J Gynecol Pathol 2001;20:323-328 (Pubitemid 32937445)
30. Reichert RA. Primary ovarian adenofibromatous neoplasms with mucin-containing signet-ring cells: a report of 2 cases. Int J Gynecol Pathol 2007;26:165-172
31. Vang R, Gown AM, Barry TS, et al. Cytokeratins 7 and 20 in primary and secondary mucinous tumors of the ovary: analysis of coordinate immunohistochemical expression profiles and staining distribution in 179 cases. Am J Surg Pathol 2006;30:1130-1139 (Pubitemid 44299346)
32. Rullier A, Le Bail B, Fawaz R, et al. Cytokeratin 7 and 20 expression in cholangiocarcinomas varies along the biliary tract but still differs from that in colorectal carcinoma metastasis. Am J Surg Pathol 2000;24:870-876 (Pubitemid 30366276)
33. Ji H, Isacson C, Seidman JD, et al. Cytokeratins 7 and 20, Dpc4, and MUC5AC in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors: Dpc4 assists in identifying metastatic pancreatic carcinomas. Int J Gynecol Pathol 2002;21:391-400. (Pubitemid 35052704)
34. Goldstein NS, Bassi D, Uzieblo A. WT1 is an integral component of an antibody panel to distinguish pancreaticobiliary and some ovarian epithelial neoplasms. Am J Clin Pathol 2001;116:246-252 (Pubitemid 33044330)
35. Chu PG, Schwarz RE, Lau SK, et al. Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol 2005;29:359-367
36. Argani P, Shaukat A, Kaushal M, et al. Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts. Cancer 2001;91:1332-1341
37. Chuang SC, Lee KT, Tsai KB, et al. Immunohistochemical study of DPC4 and p53 proteins in gallbladder and bile duct cancers. World J Surg 2004;28:995-1000.
38. Parwani AV, Geradts J, Caspers E, et al. Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions. Mod Pathol 2003;16:299-308. (Pubitemid 36443978)