From Krukenberg to today: The ever present problems posed by metastatic tumors in the ovary: Part I. Historical perspective, general principles, mucinous tumors including the krukenberg tumor

Advances in Anatomic Pathology

Volumn 13, Issue 5, 2006, Pages 205-227

  Young, Robert H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

History; Krukenberg tumor; Metastasis; Mucinous neoplasms; Ovary

Indexed keywords

CYTOKERATIN 7; ESTROGEN RECEPTOR; MUCIN 1; MUCIN 2; MUCIN 5AC; PROTEINASE ACTIVATED RECEPTOR 1; TRANSCRIPTION FACTOR CDX2;

ANDROBLASTOMA; APPENDIX TUMOR; COLORECTAL CARCINOMA; DIFFERENTIAL DIAGNOSIS; GALLBLADDER CARCINOMA; HISTORY OF MEDICINE; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; MESOTHELIOMA; MICROSCOPY; MUCINOUS CARCINOMA; OVARY CARCINOMA; OVARY METASTASIS; PANCREAS ADENOCARCINOMA; PERITONEUM PSEUDOMYXOMA; PRIORITY JOURNAL; REVIEW; SIGNET RING CARCINOMA; STOMACH TUMOR; UTERINE CERVIX TUMOR;

ADENOCARCINOMA, MUCINOUS; APPENDICEAL NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; FEMALE; HISTORY, 20TH CENTURY; HUMANS; KRUKENBERG TUMOR; MEDICAL ONCOLOGY; OVARIAN NEOPLASMS; PANCREATIC NEOPLASMS; PERIODICALS;

EID: 33748964531     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/01.pap.0000213038.85704.e4     Document Type: Review

References (70)

1. Young RH. From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II. Non-mucinous neoplasms. Adv Anat Pathol. In press.
2. Krukenberg FE. Uber Das Fibrosarcoma ovarii mucocellulare (carcinomatodes). Arch Gynäkol. 1896;50:287-321.
3. Paget J. Lectures on Surgical Pathology. Philadelphia: Lindsay and Blakiston; 1854:510.
4. Shenoy BV, Scheithauer BW. Paget's perspectives in pathology. Mayo Clin Proc. 1988;63:184-192.
5. Jarcho J. Further studies on the Krukenberg tumor of the ovary. Am J Surg. 1938;41:538-564.
6. Gauthier-Villars P. Étude des métastases ovariennes des épithéliomas digestifs. Ann D'Anat Pathol. 1928;5:1-24.
7. Dallenbach-Hellweg G, Schmidt D. History of gynecological pathology. VI. Jacob Felix Marchand. Int J Gynecol Pathol. 1999;18:281-287.
8. Speert H. Obstetrical-gynecological eponyms: Friedrich Krukenberg and ovarian tumors. Cancer. 1955;8:869-871.
9. Kraus E. Über das zustandekommen der krebsmetastasen im ovarium bei primärem kerbs eines anderen bauchorgans. Monatsschr Geburtsh Gynakol. 1901;14:1-30.
10. Wagner GA. Zur histogenese der sogenannten Krukenbergschen ovarial tumoren. Weiner Klinische Wochenshrift. 1902;15:519-523.
11. Schlagenhaufer F. Ueber das metastatische ovarial-carcinom nach Krebs des Magens, Darmes, und anderer Bauchorgane. Monatschr. F. Geburtsh. U. Gynackol. 1896;15:485.
12. Stone WS. Metastatic carcinoma of the ovaries. Surg Gynecol Obstet. 1916;22:407-423.
13. Jarcho J. Krukenberg tumors and their practical problems. Am J Obstet Gynecol. 1924;13:288-307.
14. Kiyokawa T, Young RH, Scully RE. Krukenberg tumors of the ovary. A clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations. Am J Surg Pathol. 2006;30:277-299.
15. Bland-Sutton J. A clinical lecture on secondary (metastatic) carcinoma of the ovaries. Brit Med J. 1906;1216-1217.
16. Ley G. Primary and secondary carcinoma of the ovary: a statistical record from the pathological institute of the London hospital. Proc Roy Soc Med. 1919;13:95-127.
17. Frankl O. Beitrage zur pathologie und klinik des ovarialkarzinoms mit besonderer berticksichtigung des carcinoma ovarii metastaticum (Contributions to pathology and clinical aspects of ovarian carcinoma with special emphasis on metastatic ovarian carcinoma). Arch Gynak. 1920;113:29-132.
18. Burt CAV. Prophylactic oophorectomy with resection of the large bowel for cancer. Am J Surg. 1971;82:571-577.
19. Wheelock MC, Putong P. Ovarian metastases from adenocarcinomas of colon and rectum. Obstet Gynecol. 1959;14:291-295.
20. Scully RE, Morris JM. Functioning ovarian tumors. In: Meigs J, Sturgis SH, eds. Progress in Gynecology, III. New York: Grune & Stratton; 1957:31-33.
21. Scully RE, Richardson GS. Luteinization of the stroma of metastatic cancer involving the ovary and its endocrine significance. Cancer. 1961;14:827-840.
22. Scully RE. Ovarian tumours with functioning stroma. In: Fox H, ed. Haines and Taylor. Obstetrical and Gynaecological Pathology. 4th ed. New York: Churchill-Livingstone; 1995.
23. Lash RH, Hart WR. Intestinal adenocarcinomas metastatic to the ovaries. A clinicopathological evaluation of 22 cases. Am J Surg Pathol. 1987;11:114-121.
24. Young RH, Hart WR. Metastases from carcinomas of the pancreas simulating primary mucinous tumors of the ovary: a report of seven cases. Am J Surg Pathol. 1989;13:748-756.
25. Young RH. Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms. Semin Diagn Pathol. 2004;21:134-150.
26. Baker PM, Oliva E. Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. Int J Gynecol Pathol. 2004;24:39-55.
27. McCluggage WG, Wilkinson N. Metastatic neoplasms involving the ovary: a review with an emphasis on morphological and immunohistochemical features. Histopathology. 2005;47:231-247.
28. McCluggage WG, Young RH. Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors. Semin Diagn Pathol. 2005;22:3-32.
29. Hart WR. Diagnostic challenge of secondary (metastatic) ovarian tumors simulating primary endometrioid and mucinous neoplasms. Pathol Int. 2005;55:321-343.
30. Young RH, Scully RE. Differential diagnosis of ovarian tumors based primarily on their patterns and cell types. Semin Diagn Pathol. 2001;18:161-235.
31. Young RH, Scully RE. Metastatic tumors in the ovary: a problem-oriented approach and review of the recent literature. Semin Diagn Pathol. 1991;8:250-276.
32. Bullon A, Arseneau J, Prat J, et al. Tubular Krukenberg tumor. A problem in histopathologic diagnosis. Am J Surg Pathol. 1981;5:225-232.
33. Seidman JD, Kurman RJ, Ronnett BM. Primary and metastatic mucinous adenocarcinomas in the ovaries. Incidence in routine practice with a new approach to improve intraoperative diagnosis. Am J Surg Pathol. 2003;27:485-993.
34. Lewis MR, Deavers MT, Silva EG, et al. Ovarian involvement by metastatic colorectal adenocarcinoma. Still a diagnostic challenge. Am J Surg Pathol. 2006;30:177-184.
35. Khunamornpong S, Suprasert P, Chiangmai WN, et al. Metastatic tumors to the ovaries: a study of 170 cases in Northern Thailand. Int J Gynecol Cancer. 2006;16(suppl 1):132-138.
36. Khunamornpong S, Suprasert PS, Pojchamarnwiputh S, et al. Primary and metastatic mucinous adenocarcinomas of the ovary: evaluation of the diagnostic approach using tumor size and laterality. Gynecol Oncol. 2006;101:152-157.
37. Stewart CJR, Brennan BA, Hammond IG, et al. Accuracy of frozen section in distinguishing primary ovarian neoplasia from tumors metastatic to the ovary. Int J Gynecol Pathol. 2005;24:356-362.
38. Willis RA. The Spread of Tumors in the Human Body. 3rd ed. London: Butterworths; 1973:224-225.
39. Lee KR, Young RH. The distinction between primary and metastatic mucinous carcinoma of the ovary. Gross and histologic finding in 50 cases. Am J Surg Pathol. 2003;27:281-292.
40. Schiller W, Kozoll DD. Primary signet-ring cell carcinoma of the ovary. Am J Obstet Gynecol. 1941;41:3-11.
41. Joshi VV. Primary Krukenberg tumor of ovary. Review of literature and case report. Cancer. 1968;22:1199-1207.
42. Tamura PY, Curtiss C. Carcinoma of the stomach in the young adult. Cancer. 1960;13:379-385.
43. Saphir O. Signet-ring cell carcinoma. Mil Surg. 1951;109:360-369.
44. Jarcho S. Diffusely infiltrating carcinoma. A hitherto underscribed correlation of several varieties of tumor metastasis. Arch Path. 1936;22:674-687.
45. Diddle AW. Krukenberg tumors: diagnostic problem. Cancer. 1955;8:1026-1034.
46. Irving JA, Vasques DR, McGuinness TB, et al. Krukenberg tumor of renal pelvic origin: report of a case with selected comments on ovarian tumors metastatic from the urinary tract. Int J Gynecol Pathol. 2006;25:147-150.
47. Yakushiji M, Tazaki T, Nishimura H, et al. Krukenberg tumors of the ovary: a clinicopathologic analysis of 112 cases. Acta Obstet Gynecol Scand. 1987;39:479-485.
48. Ronnett BM, Kurman RJ, Shmookler BM, et al. The morphologic spectrum of ovarian metastases of appendical adenocarcinomas. A clinicopathologic and immunohistochemical analysis of tumors often misinterpreted as primary ovarian tumors or metastatic tumors from other gastrointestinal sites. Am J Surg Pathol. 1997;2:1144-1155.
49. Lerwill MF, Young RH. Ovarian metastases of intestinal-type gastric carcinoma. A clinicopathologic study of 4 cases with contrasting features to those of the Krukenberg tumor. Am J Surg Pathol. In press.
50. Holtz F, Hart WR. Krukenberg tumors of the ovary. A clinicopathologic analysis of 27 cases. Cancer. 1982;50:2438-2447.
51. Che M, Tornos C, Deavers MT, et al. Ovarian mixed-epithelial carcinomas with a microscopic pattern and signet-ring cells. Int J Gynecol Pathol. 2001;20:333-328.
52. Eichhorn JH, Young RH. Transitional cell carcinoma of the ovary. A morphologic study of 100 cases with emphasis on differential diagnosis. Am J Surg Pathol. 2004;28:453-465.
53. Kuo T-T, Hsueh S. Mucicarminophilic histiocytosis. A polyvinyl- pyrrolidone (PVP) storage disease simulating signet-ring cell carcinoma. Am J Surg Pathol. 1984;8:419-428.
54. Phillips V, McCluggage WG, Young RH. Oxyphilic adenomatoid tumour of the ovary: a case report with discussion of the differential diagnosis of ovarian tumours with vacuoles and related spaces. Int J Gynecol Pathol. In press.
55. Chu PG, Weiss LM. Immunohistochemical characterization of signet-ring cell carcinomas of the stomach, breast, and colon. Am J Clin Pathol. 2004;121:884-892.
56. Misdraji J, Yantiss RK, Graeme-Cook F, et al. Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases. Am J Surg Pathol. 2003;27:1089-1103.
57. Pai RK, Longacre TA. Appendiceal mucinous tumors and pseudomyxoma peritonei. Histologic features, diagnostic problems, and proposed classification. Adv Anat Pathol. 2005;12:291-311.
58. Bradley RF, Stewart JH, Russell GB, et al. Pseudomyxoma peritonei of appendiceal origin: a clinicopathologic analysis of 101 patients uniformly treated at a single institution, with literature review. Am J Surg Pathol. 2006;30:551-559.
59. Young RH, Gilks CB, Scully RE. Mucinous tumors of the appendix associated with mucinous tumors of the ovary and pseudomyxoma peritonei: a clinicopathological analysis of 22 cases supporting an origin in the appendix. Am J Surg Pathol. 1991;15:415-429.
60. Seidman JD, Elsayed AM, Sobin LH, et al. Association of mucinous tumors of the ovary and appendix. A clinicopathologic study of 25 cases. Am J Surg Pathol. 1933;17:22-34.
61. Prayson RA, Hart WR, Petras RE. Pseudomyxoma peritonei. A clinicopathologic study of 19 cases with emphasis on site of origin and nature of associated ovarian tumors. Am J Surg Pathol. 1994;18:591-603.
62. Ronnett BM, Kurman RJ, Zahn CM, et al. Pseudomyxoma peritonei in women. A clinicopathologic analysis of 30 cases with emphasis on site of origin, prognosis, and relationship to ovarian mucinous tumors of low malignant potential. Hum Pathol. 1995;26:509-524.
63. Ronnett BM, Zahn CM, Kurman RJ, et al. Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis: a clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to "pseudomyxoma peritonei". Am J Surg Pathol. 1995;19:1390-1408.
64. Young RH, Scully RE. Ovarian metastases from carcinoma of the gallbladder and extrahepatic bile ducts simulating primary tumors of the ovary: a report of six cases. Int J Gynecol Pathol. 1990;9:60-72.
65. Young RH, Scully RE. Mucinous tumors of the ovary associated with mucinous adenocarcinomas of the cervix. A clinicopathological analysis of 16 cases. Int J Gynecol Pathol. 1988;7:99-111.
66. Kaminski PF, Norris HJ. Coexistence of ovarian neoplasms and endocervical adenocarcinoma. Obstet Gynecol. 1984;64:553-556.
67. LiVolsi VA, Merino MJ, Schwartz PE. Coexistent endocervical adenocarcinoma and mucinous adenocarcinoma of ovary: a clinicopathologic study of four cases. Int J Gynecol Pathol. 1983;1:391-402.
68. Elishaev E, Gilks CB, Miller D, et al. Synchronous and metachronous endocervical and ovarian neoplasms. Evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasms. Am J Surg Pathol. 2005;29:281-294.
69. Ohira S, Shiohara S, Itoh K, et al. Urachal adenocarcinoma metastatic to the ovaries: case report and literature review. Int J Gynecol Pathol. 2003;22:189-193.
70. Irving JA, Young RH. Lung carcinoma metastatic to the ovary. A clinicopathologic study of 32 cases emphasizing their morphologic spectrum and problems in differential diagnosis. Am J Surg Pathol. 2005;29:997-1006.