Induction of Th1-type cellular responses in cured/exposed Leishmania-infected patients and hamsters against polyproteins of soluble Leishmania donovani promastigotes ranging from 89.9 to 97.1 kDa

Vaccine

Volumn 26, Issue 37, 2008, Pages 4813-4818

  Kumari, Shraddha ^a   Samant, Mukesh ^a   Khare, Prashant ^a   Sundar, Shyam ^b   Sinha, Sudhir ^a   Dube, Anuradha ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

Cured Leishmania patients hamsters; Cytokines; LTT; Soluble Leishmania donovani (SLD) promastigotes; Th1 stimulatory proteins

Indexed keywords

AMPHOTERICIN B; GAMMA INTERFERON; INTERLEUKIN 12; NITRIC OXIDE; POLYPROTEIN;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CASE REPORT; CELLULAR IMMUNITY; CHILD; CONTROLLED STUDY; CYTOKINE PRODUCTION; HAMSTER; HUMAN; HUMAN TISSUE; IMMUNOSTIMULATION; INTERFERON PRODUCTION; LEISHMANIA DONOVANI; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROMASTIGOTE; TH1 CELL;

ANIMALS; ANTIGENS, PROTOZOAN; CELL PROLIFERATION; CRICETINAE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LEISHMANIA DONOVANI; LEISHMANIASIS VACCINES; MALE; MOLECULAR WEIGHT; NITRIC OXIDE; PROTOZOAN PROTEINS; T-LYMPHOCYTE SUBSETS; TH1 CELLS;

EID: 49549114854     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.06.102     Document Type: Article

References (27)

1. Guerin P.J., Olliaro P., Sundar S., Boelaert M., Croft S.L., Desjeux P., et al. Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infect Dis 2 8 (2002) 494-501
2. Desjeux P. Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis 27 5 (2004) 305-318
3. Murray H.W., Hariprashad J., and Coffman R.L. Behavior of visceral Leishmania donovani in an experimentally induced T helper cell 2 (Th2)-associated response model. J Exp Med 185 5 (1997) 867-874
4. Bhowmick S., Ravindran R., and Ali N. Leishmanial antigens in liposomes promote protective immunity and provide immunotherapy against visceral leishmaniasis via polarized Th1 response. Vaccine 25 (2007) 6544-6556
5. Reed S.G., and Scott P. T-cell and cytokine responses in leishmaniasis. Curr Opin Immunol 5 4 (1993) 524-531
6. Skeiky Y.A., Kennedy M., Kaufman D., Borges M.M., Guderian J.A., Scholler J.K., et al. LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile. J Immunol 161 11 (1998) 6171-6179
7. Coler R.N., Skeiky Y.A., Bernards K., Greeson K., Carter D., Cornellison C.D., et al. Immunization with a polyprotein vaccine consisting of the T-Cell antigens thiol-specific antioxidant, Leishmania major stress-inducible protein 1, and Leishmania elongation initiation factor protects against leishmaniasis. Infect Immun 70 8 (2002) 4215-4225
8. Garg R., Gupta S.K., Tripathi P., Naik S., Sundar S., and Dube A. Immunostimulatory cellular responses of cured Leishmania-infected patients and hamsters against the integral membrane proteins and non-membranous soluble proteins of a recent clinical isolate of Leishmania donovani. Clin Exp Immunol 140 1 (2005) 149-156
9. Pirmez C., Yamamura M., Uyemura K., Paes-Oliveira M., Conceicao-Silva F., and Modlin R.L. Cytokine patterns in the pathogenesis of human leishmaniasis. J Clin Invest 91 4 (1993) 1390-1395
10. Russo D.M., Armitage R.J., Barral-Netto M., Barral A., Grabstein K.H., and Reed S.G. Antigen-reactive gamma delta T cells in human leishmaniasis. J Immunol 151 7 (1993) 3712-3718
11. Garg R., Gupta S.K., Tripathi P., Hajela K., Sundar S., Naik S., et al. Leishmania donovani: identification of stimulatory soluble antigenic proteins using cured human and hamster lymphocytes for their prophylactic potential against visceral leishmaniasis. Vaccine 24 15 (2006) 2900-2909
12. Dube A., Singh N., and Sundar S. Refractoriness to the treatment of sodium stibogluconate in Indian kala-azar field isolates persist in in vitro and in vivo experimental models. Parasitol Res 96 4 (2005) 216-223
13. Gupta S.K., Sisodia B.S., Sinha S., Hajela K., Naik S., Shasany A.K., et al. Proteomic approach for identification and characterization of novel immunostimulatory proteins from soluble antigens of Leishmania donovani promastigotes. Proteomics 7 5 (2007) 816-823
14. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 193 1 (1951) 265-275
15. Sundar S., Reed S.G., Sharma S., Mehrotra A., and Murray H.W. Circulating T helper 1 (Th1) cell- and Th2 cell-associated cytokines in Indian patients with visceral leishmaniasis. Am J Trop Med Hyg 56 5 (1997) 522-525
16. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 5259 (1970) 680-685
17. Wray W., Boulikas T., Wray V.P., and Hancock R. Silver staining of proteins in polyacrylamide gels. Anal Biochem 118 1 (1981) 197-203
18. Wessel D., and Flügge U.I. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal Biochem 138 (1984) 141-143
19. Arand M., Friedberg T., and Oesch F. Colorimetric quantitation of trace amounts of sodium lauryl sulfate in the presence of nucleic acids and proteins. Anal Biochem 207 (1992) 73-75
20. Ding A.H., Nathan C.F., and Stuehr D.J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J Immunol 141 7 (1988) 2407-2412
21. Assreuy J., Cunha F.Q., Epperlein M., Noronha-Dutra A., O'Donnell C.A., Liew F.Y., et al. Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major. Eur J Immunol 24 3 (1994) 672-676
22. MacMicking J., Xie Q.W., and Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol 15 (1997) 323-350
23. Sacks D., and Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol 2 11 (2002) 845-858
24. Russo D.M., Burns Jr. J.M., Carvalho E.M., Armitage R.J., Grabstein K.H., Button L.L., et al. Human T cell responses to gp63, a surface antigen of Leishmania. J Immunol 147 10 (1991) 3575-3580
25. Burns Jr. J.M., Scott J.M., Carvalho E.M., Russo D.M., March C.J., Van Ness K.P., et al. Characterization of a membrane antigen of Leishmania amazonensis that stimulates human immune responses. J Immunol 146 2 (1991) 742-748
26. Basu R., Bhaumik S., Basu J.M., Naskar K., De T., and Roy S. Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: evidence for mixed Th1- and Th2-like responses in visceral leishmaniasis. J Immunol 174 11 (2005) 7160-7171
27. Tripathi P., Ray S., Sunder S., Dube A., and Naik S. Identification of Leishmania donovani antigens stimulating cellular immune responses in exposed immune individuals. Clin Exp Immunol 143 2 (2006) 380-388