Effects of therapeutic doses of Pregabalin on QTc interval in conscious rabbits

European Review for Medical and Pharmacological Sciences

Volumn 12, Issue 4, 2008, Pages 223-228

  Alp, Recep ^a   Citil, M ^b   Uzun, M ^b   Alp, S ^c   Topcu, B ^b   Uzlu, E ^b   Erdogan, H M ^b  

^a KAFKAS UNIVERSITY   (Turkey)

^b KAFKAS UNIVERSITY   (Turkey)

^c Kars State Hospital   (Turkey)

Author keywords

ECG; Pregabalin; QT

Indexed keywords

PREGABALIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; CONSCIOUSNESS; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; ELECTROCARDIOGRAM; FEMALE; HEART RATE; MALE; NONHUMAN; QT INTERVAL; RABBIT; SINGLE DRUG DOSE;

ADMINISTRATION, ORAL; ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; FEMALE; GAMMA-AMINOBUTYRIC ACID; HEART RATE; LONG QT SYNDROME; MALE; RABBITS; TIME FACTORS;

EID: 49549098428     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. GUAY D. Pregabaline in neuropathic pain: A more "pharmaceutically elegant" gabapentin? Pharmacother 2005; 3: 274-287.
2. TAYLOR CP, ANGELOTTI T, FAUMAN E. Pharmacology and mechanism of action of pregabalin: The calcium channel α2-δ (alpha2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res 2007; 73: 137-150.
3. EUROPEAN MEDICINES AGENCY. EPARs for authorised medicinal products for human use. Available. From: Http://www.emea.eu.int/humandocs/Humans/EPAR/lyrica/lyrica.htm. 18/12/2007.
4. MURPHY N, MOCKLER M, RYDER M, LEDWIDGE M, MCDONALD K. Decompensation of chronic heart failure associated with pregabalin in patients with neuropathic pain. J Card Fail 2007; 13: 227-229.
5. LAVILLE MA, DE LA GASTINE B, HUSSON B, LE BOISELIER R, MOSQUET B, COQUEREL A. Should we care about pregabalin for elderly patients with a history of cardiac dysrhythmia? Rev Med Interne 2008; 29: 152-154.
6. YAP YG, CAMM J. Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause QT prolongation. Br Med J 2000; 320: 1158-1159.
7. BODI I, MIKALA G, KOCH SE, AKHTER SA, SCHWARTZ A. The L-type calcium channel in the heart: The beat goes on. J Clin Invest 2005; 115: 3306-3317.
8. 2+ channels in the heart. Circ Res 2007; 101: 69-77.
9. UZUN M, YAPAR K, UZLU E, CITIL M, ERDOGAN HM. QT interval prolongation and decreased heart rates after intravenous bolus oxytocin injection in male and female conscious rabbits. Gen Physiol Biophys 2007; 26: 168-172.
10. KUTAWORNRAT A, OZKANLAR Y, KEENE BW, ROCHE BM, HAMLIN DM, HAMLIN RL. Assessment of drug-induced QT interval prolongation in conscious rabbits. J Pharmacol Toxicol Method 2006; 53: 168-173.
11. TASSONE DM, BOYCE E, GUYER J, NUZUM D. Pregabalin: A novel gamma-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders. Clin Ther 2007; 29: 26-48.
12. PIYAPOLRUNGROJ N, LI C, BOCKBRADER H, LIU G, FLEISHER D. Mucosal uptake of gabapentin (neurontin) vs. pregabalin in the small intestine. Pharm Res 2001; 18: 1126-1130.
13. 2+ channel kinetics in acutely isolated fetal, neonatal, and adult rabbit cardiac myocytes. Circ Res 1993; 72: 1065-1074.
14. ANDERSON ME. Calmodulin Kinase and L-Type Calcium channels: A recipe for arrhythmias? Trends Cardiovasc Med 2004; 14: 152-161.
15. HEIST EK, RUSKIN JN. Drug-induced proarrhythmia and use of QTc-prolonging agents: Clues for clinicians. Heart Rhythm 2005; 2(2 Suppl): 1-8.