Inorganic polyhedral metallacarborane inhibitors of HIV protease: A new approach to overcoming antiviral resistance

Journal of Medicinal Chemistry

Volumn 51, Issue 15, 2008, Pages 4839-4843

  Kožíšek, Milan ^a,b   Cígler, Petr ^a,c   Lepšík, Martin ^a   Fanfrlík, Jindřich ^a   Řezáčová, Pavlína ^a,d   Brynda, Jiří ^a,d   Pokorná, Jana ^a   Plešek, Jaromír ^e   Grüner, Bohumír ^e   Šašková, Klára Grantz ^a,b   Václavíková, Jana ^a   Král, Vladimír ^c   Konvalinka, Jan ^a,b,d  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF CHEMICAL TECHNOLOGY   (Czech Republic)

^d INSTITUTE OF MATHEMATICS   (Czech Republic)

^e INSTITUTE OF INORGANIC CHEMISTRY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

3 COBALT BIS(1,2 DICARBOLLIDE); AMPRENAVIR; ATAZANAVIR; CARBORANE DERIVATIVE; DARUNAVIR; GB 18; GB 21; GB 48; GB 80; INDINAVIR; LOPINAVIR; NELFINAVIR; PROTEINASE; PROTEINASE INHIBITOR; SAQUINAVIR; UNCLASSIFIED DRUG;

ANTIVIRAL RESISTANCE; ARTICLE; BINDING AFFINITY; HUMAN IMMUNODEFICIENCY VIRUS; MOLECULAR MODEL; MUTAGENESIS; STRUCTURE ANALYSIS; X RAY ANALYSIS;

BORON COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, VIRAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; METALS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION;

EID: 49449113806     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8002334     Document Type: Article

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