Evaluation of hepatic uptake clearance of tetrodotoxin in the puffer fish Takifugu rubripes

Toxicon

Volumn 52, Issue 2, 2008, Pages 369-374

  Matsumoto, Takuya ^a   Nagashima, Yuji ^a   Kusuhara, Hiroyuki ^b   Ishizaki, Shoichiro ^a   Shimakura, Kuniyoshi ^a   Shiomi, Kazuo ^a  

^a TOKYO UNIVERSITY OF MARINE SCIENCE AND TECHNOLOGY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Hepatic accumulation; Hepatic first pass effect; Hepatic uptake clearance; Integration plot analysis; Pharmacokinetics; Puffer fish Takifugu rubripes; Single administration; Tetrodotoxin; Toxification

Indexed keywords

TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW VELOCITY; BLOOD LEVEL; CONTROLLED STUDY; FIRST PASS EFFECT; KIDNEY; LIVER CLEARANCE; LIVER METABOLISM; NONHUMAN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; PUFFER FISH; SPLEEN; TOXICITY TESTING;

ANIMALS; BODY WEIGHT; INJECTIONS, INTRAVENOUS; LIVER; ORGAN SIZE; POISONS; TAKIFUGU; TETRODOTOXIN; TISSUE DISTRIBUTION;

TAKIFUGU RUBRIPES; TETRAODONTIDAE;

EID: 49449105801     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2008.06.006     Document Type: Article

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