Specific interaction of the unmodified bacteriocin lactococcin 972 with the cell wall precursor lipid II

Applied and Environmental Microbiology

Volumn 74, Issue 15, 2008, Pages 4666-4670

  Martínez, Beatriz ^a   Böttiger, Tim ^b   Schneider, Tanja ^b   Rodriguez, Ana ^a   Sahl, Hans Georg ^b   Wiedemann, Imke ^b  

^a DEPARTMENT OF MICROBIOLOGY AND BIOCHEMISTRY OF DAIRY PRODUCTS   (Spain)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BINDING ENERGY; BINDING SITES; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; CELLS; CHEMICAL REACTIONS; COLLOIDS; CYTOLOGY; FORMING; LIPOSOMES; MONOMERS; PHOSPHOLIPIDS; POLYMERS; WALLS (STRUCTURAL PARTITIONS);

BACTERIOCIN; CELL WALLS; CYTOPLASMIC MEMBRANES; IN VITRO POLYMERIZATION; IN-VIVO; INHIBITORY ACTIVITIES; LACTOCOCCIN; LACTOCOCCUS LACTIS; MODE OF ACTION; MOLECULAR BASES; PHOSPHOCHOLINE; PORE FORMATIONS; S. AUREUS; SPECIFIC INTERACTIONS; WHOLE CELLS;

CELL MEMBRANES;

BACTERIOCIN; GLYCINE; LACTOCOCCIN; LIPID; LIPOSOME; NISIN;

ANTIBIOTICS; BACTERIUM; EXPERIMENTAL STUDY; INHIBITOR; LIPID; MOLECULAR ANALYSIS; PEPTIDE; POLYMERIZATION;

BINDING AFFINITY; BINDING SITE; CATALYSIS; CELL WALL; CONFERENCE PAPER; CONTROLLED STUDY; MICELLE; NONHUMAN; POLYMERIZATION; POROSITY; PRECIPITATION; PROTEIN BINDING; PROTEIN INTERACTION; STAPHYLOCOCCUS AUREUS; WHOLE CELL;

BACTERIOCINS; CELL MEMBRANE; CELL WALL; FLUORESCEINS; KINETICS; LACTOCOCCUS LACTIS; MEMBRANE LIPIDS; POTASSIUM;

LACTOCOCCUS LACTIS; STAPHYLOCOCCUS AUREUS;

EID: 49449104724     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.00092-08     Document Type: Conference Paper

References (26)

1. Archibald, A. R., I. C. Hancock, and C. R. Harwood. 1993. Cell wall structure, synthesis, and turnover, p. 381-410. In A. L. Sonenshein, J. A. Hoch, and R. Losick (ed.), Bacillus subtilis and other gram-positive bacteria: biochemistry, physiology, and molecular genetics. American Society for Microbiology, Washington, DC.
2. Barrett, D., C. Leimkuhler, L. Chen, D. Walker, D. Kahne, and S. Walker. 2005. Kinetic characterization of the glycosyltransferase module of Staphylococcus aureus PBP2. J. Bacteriol. 187:2215-2217.
3. Bonelli, R. R., I. Wiedemann, and H. G. Sahl. 2006. Lantibiotics, p. 97-105. In A. Kastin (ed.), Handbook of biologically active peptides. Elsevier, New York, NY.
4. Bonelli, R. R., T. Schneider, H. G. Sahl, and I. Wiedemann. 2006. Insights into in vivo activities of lantibiotics from gallidermin and epidermin mode-of-action studies. Antimicrob. Agents Chemother. 50:1449-1457.
5. Breukink, E., I. Wiedemann, C. van Kraaij, O. P. Kuipers, H. G. Sahl, and B. de Kruijff. 1999. Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic. Science 286:2361-2364.
6. Breukink, E., and B. de Kruijff. 2006. Lipid II as a target for antibiotics. Nat. Rev. Drug Discov. 5:321-323.
7. Brötz, H., G. Bierbaum, A. Markus, E. Mollitor, and H. G. Sahl. 1995. Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism? Appl. Environ. Microbiol. 39:714-719.
8. Brötz, H., M. Josten, I. Wiedemann, U. Schneider, F. Gotz, G. Bierbaum, and H. G. Sahl. 1998. Role of lipid-bound peptidoglycan precursors in the formation of pores by nisin, epidermin, and other lantibiotics. Mol. Microbiol. 30:317-327.
9. Cotter, P. D., C. Hill, and R. P. Ross. 2005. Bacteriocins: developing innate immunity for food. Nat. Rev. Microbiol. 3:777-788.
10. Diep, D. B., M. Skaugen, Z. Salehian, H. Holo, and I. F. Nes. 2007. Common mechanisms of target cell recognition and immunity for class II bacteriocins. Proc. Natl. Acad. Sci. USA 104:2384-2389.
11. Hsu, S. T., E. Breukink, E. Tischenko, M. A. Lutters, B. de Kruijff, R. Kaptein, A. M. Bonvin, and N. A. van Nuland. 2004. The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics. Nat. Struct. Mol. Biol. 11:963-967.
12. Kramer, N. E., E. J. Smid, J. Kok, B. de Kruijff, O. P. Kuipers, and E. Breukink. 2004. Resistance of gram-positive bacteria to nisin is not determined by lipid II levels. FEMS Microbiol. Lett. 239:157-161.
13. Kuroda, M., H. Kuroda, T. Oshima, F. Takeuchi, H. Mori, and K. Hiramatsu. 2003. Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus. Mol. Microbiol. 49:807-821.
14. Martínez, B., A. Rodríguez, and J. E. Suárez. 2000. Lactococcin 972, a bacteriocin that inhibits septum formation in lactococci. Microbiology 146: 949-955.
15. Martínez, B., A. L. Zomer, A. Rodríguez, J. Kok, and O. P. Kuipers. 2007. Cell envelope stress induced by the bacteriocin Lcn972 is sensed by the lactococcal two-component system CesSR. Mol. Microbiol. 64:473-486.
16. Martínez, B., J. E. Suárez, and A. Rodríguez. 1996. Lactococcin 972, a homodimeric lactococcal bacteriocin whose primary target is not the plasma membrane. Microbiology 142:2393-2398.
17. Mascher, T., N. G. Margulis, T. Wang, R. W. Ye, and J. D. Helmann. 2003. Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon. Mol. Microbiol. 50:1591-1604.
18. Mascher, T. 2006. Intramembrane-sensing histidine kinases: a new family of cell envelope stress sensors in Firmicutes bacteria. FEMS Microbiol. Lett. 264:133-144.
19. Orlov, D. S., T. Nguyen, and R. I. Lehrer. 2002. Potassium release, a useful tool for studying antimicrobial peptides. J. Microbiol. Methods 49:325-328.
20. Rick, P. D., G. L. Hubbard, M. Kitaoka, H. Nagaki, T. Kinoshita, S. Dowd, V. Simplaceanu, and C. Ho. 1998. Characterization of the lipid-carrier involved in the synthesis of enterobacterial common antigen (ECA) and identification of a novel phosphoglyceride in a mutant of Salmonella typhimurium defective in ECA synthesis. Glycobiology 8:557-567.
21. Schneider, T., M. M. Senn, B. Berger-Bachi, A. Tossi, H. G. Sahl, and I. Wiedemann. 2004. In vitro assembly of a complete, pentaglycine interpeptide bridge containing cell wall precursor (lipid II-Gly5) of Staphylococcus aureus. Mol. Microbiol. 53:675-685.
22. van Heijenoort, J. 2001. Formation of the glycan chains in the synthesis of bacterial peptidoglycan. Glycobiology 11:25R-36R.
23. van Heijenoort, J. 2007. Lipid intermediates in the biosynthesis of bacterial peptidoglycan. Microbiol. Mol. Biol. Rev. 71:620-635.
24. Wiedemann, I., E. Breukink, C. van Kraaij, O. P. Kuipers, G. Bierbaum, B. de Kruijff, and H. G. Sahl. 2001. Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. J. Biol. Chem. 276:1772-1779.
25. Wiedemann, I., T. Bottiger, R. R. Bonelli, A. Wiese, S. O. Hagge, T. Gutsmann, U. Seydel, L. Deegan, C. Hill, P. Ross, and H. G. Sahl. 2006. The mode of action of the lantibiotic lacticin 3147: a complex mechanism involving specific interaction of two peptides and the cell wall precursor lipid II. Mol. Microbiol. 61:285-296.
26. Wiedemann, I., T. Bottiger, R. R. Bonelli, T. Schneider, H. G. Sahl, and B. Martinez. 2006. Lipid II-based antimicrobial activity of the lantibiotic plantaricin C. Appl. Environ. Microbiol. 72:2809-2814.