Immunogenicity, reactogenicity and safety of a diphtheria-tetanus-acellular pertussis-inactivated polio and Haemophilus Influenzae type b combination vaccine in a placebo-controlled rotavirus vaccine study

Annals of the Academy of Medicine Singapore

Volumn 37, Issue 7, 2008, Pages 546-553

  Kong, Boo Phua ^a   Seng, Hock Quak ^b   Fong, Seng Lim ^c   Goh, Paul ^d   Yee, Leong Teoh ^e   Datta, Sanjoy Kumar ^e   Han, Htay Htay ^e   Bock, Hans Ludwig ^e  

^a KK WOMEN'S AND CHILDREN'S HOSPITAL   (Singapore)

^b NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^c NATIONAL HEALTHCARE GROUP POLYCLINICS   (Singapore)

^d SINGHEALTH POLYCLINICS   (Singapore)

^e GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

Author keywords

Paediatric; Vaccination

Indexed keywords

DIPHTHERIA PERTUSSIS TETANUS HAEMOPHILUS INFLUENZAE TYPE B VACCINE; INFANRIX IPV HIB; PLACEBO; POLIOMYELITIS VACCINE; RECOMBINANT HEPATITIS B VACCINE; ROTAVIRUS VACCINE;

ANTIBODY RESPONSE; ARTICLE; BACTERIAL INFECTION; BLOOD SAMPLING; BRONCHITIS; CHILDHOOD DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVULSION; DIPHTHERIA; DOUBLE BLIND PROCEDURE; DRUG FORMULATION; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FEVER; FOLLOW UP; HEART ATRIUM SEPTUM DEFECT; HEPATITIS B; HUMAN; IMMUNIZATION; IMMUNOGENICITY; INFANT; INFECTION; INTESTINE OBSTRUCTION; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PERTUSSIS; PHARYNGITIS; PHASE 2 CLINICAL TRIAL; PNEUMONIA; POLIOMYELITIS; RANDOMIZED CONTROLLED TRIAL; REPEATED DRUG DOSE; SEROLOGY; TETANUS; UPPER RESPIRATORY TRACT INFECTION; VACCINATION; VIRUS INFECTION;

EID: 49449099387     PISSN: 03044602     EISSN: 29724066     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Goh KT. The National Childhood Immunisation Programmes in Singapore. Singapore Med J 1985;26:225-42.
2. Wong HB. Child health in Singapore - past, present and future. Ann Acad Med Singapore 1982;11:322-35.
3. Raghuram J, Ong YY, Wong SY. Tetanus in Singapore: report of three cases. Ann Acad Med Singapore 1995;24:869-73.
4. Wilder-Smith A, Ng S, Earnest A. Seroepidemiology of pertussis in the adult population of Singapore. Ann Acad Med Singapore 2006;35:780-2.
5. WHO. Vaccines, immunisations and biologicals polio reported cases. Available at: http://www-nt.who.int/vaccines/GlobalSummary/timeseries/ tsincidencepol.htm. Accessed 5 January 2004.
6. IMS Singapore Pharmaceutical Audit (Jan-Mar 2004). Singapore: IMS Health Asia Pte Ltd.
7. Phua KB, Emmanuel SC, Goh P, Quak SH, Lee BW, Han HH, et al. A rotavirus vaccine for infants: the Asian experience. Ann Acad Med Singapore 2006;35:38-9.
8. Phua KB, Quak SH, Emmanuel S, Goh PSC, Han HH, Hardt K, et al. A short report on highlights of worldwide development of RIX4414: a Singaporean experience. Vaccine 2006;24:3782-3.
9. Ward RL, Bernstein DI, Shukla R, Young EC, Sherwood JR, McNeal MM, et al. Effects of antibody to rotavirus on protection of adults challenged with a human rotavirus. J Infect Dis 1989;159:79-88.
10. Lee CY, Thipphawong J, Huang LM, Lee P-I, Chiu H-H, Lin W, et al. An evaluation of the safety and immunogenicity of a five-component acellular pertussis, diphtheria, and tetanus toxoid vaccine (DtaP) when combined with a Haemophilus influenzae type b-tetanus toxoid conjugate vaccine (PRP-T) in Taiwanese infants. Pediatrics 1999;103:25-9.
11. Richie E, Punjabi NH, Harjanto SJ, Wangsasaputral F, Sukandar M, Supriatman M, et al. Safety and immunogenicity of combined diphtheriatetanus- pertussis (whole cell and acellular)-Haemophilus influenzae-b conjugate vaccines administered to Indonesian children. Vaccine 1999;17:1384-93.
12. Kanra G, Silier T, Yurdakök K, Yavuz T, Baskan S, Ulukol B, et al. Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life. Vaccine 1999;18:947-50.
13. Lin T-Y, Wang Y-H, Chang L-Y, Chiu C-H, Huang Y-C, Tang H, et al. Safety and immunogenicity of a diphtheria, tetanus and acellular pertussis-inactivated poliovirus vaccine/Haemophilus influenzae type B combination vaccine administered to Taiwanese infants at 2, 4 and 6 months of age. Chang Gung Med J 2003;26:315-22.
14. Cheng HK, Rajadurai VS, Amin Z, Sriram B, Yee MF, Han HH, et al. Immunogenicity and reactogenicity of two regimens of diphtheria-tetanus- acellular pertussis-hepatitis B-inactivated polio and Haemophilus influenzae type b vaccines administered to infants primed at birth with hepatitis B vaccine. Southeast Asian J Trop Med Public Health 2004;35:685-92.
15. Usonis V, Meriste S, Bakasenas V, Lutsar I, Collard F. Immunogenicity and safety of a combined hepatitis A and B vaccine administered concomitantly with either a measles-mumps-rubella or a diphtheria-tetanus-acellular pertussis-inactivated poliomyelitis vaccine mixed with a Haemophilus influenzae type b conjugate vaccine in infants aged 12-18 months. Vaccine 2005;23:2602-6.
16. Zepp F, Knuf M, Heininger U, Jahn K, Collard A, Habermehl P, et al. Safety, reactogenicity and immunogenicity of a combined hexavalent tetanus, diphtheria, acellular pertussis, hepatitis B, inactivated poliovirus vaccine and Haemophilus influenzae type b conjugate vaccine, for primary immunization of infants. Vaccine 2004;22:2226-33.
17. Aristegui J, Dal-Re R, Diez-Delgado J, Marés J, Casanovas JM, García-Corbeira P, et al. Comparison of the reactogenicity and immunogenicity of a combined diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio (DTPa-HBV-IPV) vaccine, mixed with the Haemophilus influenzae type b (Hib) conjugate vaccine and administered as a single injection, with the DTPa-IPV/Hib and hepatitis B vaccines administered in two simultaneous injections to infants at 2, 4 and 6 months of age. Vaccine 2003;21:3593-600.
18. Avdicova M, Prikazsky V, Hudeckova H, Schuerman L, Willems P. Immunogenicity and reactogenicity of a novel hexavalent DTPa-HBV-IPV/Hib vaccine compared to separate concomitant injections of DTPa-IPV/Hib and HBV vaccines, when administered according to a 3, 5 and 11 month vaccination schedule. Eur J Pediatr 2002;161:581-7.
19. Shek LP, Khor ES, Tan GH, Low KT, Ong D, Roy J, et al. Comparative study of the reactogenicity of a three-component acellular pertussis vaccine and whole-cell pertussis vaccine administered to healthy Singaporean infants. Southeast Asian J Trop Med and Pub Health 2003;34:863-8.
20. Greco D, Salmaso S, Mastrantonio P, Giuliano M, Tozzie AE. A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group. N Engl J Med 1996;334:341-8.
21. Jefferson T, Rudin M, Dipietrantonj C. Systematic review of the effects of pertussis vaccines in children. Vaccine 2003;21:2003-14.