Regulation of cocaine- and amphetamine-regulated transcript-synthesising neurons of the hypothalamic paraventricular nucleus by endotoxin; Implications for lipopolysaccharide-induced regulation of energy homeostasis

Journal of Neuroendocrinology

Volumn 20, Issue 9, 2008, Pages 1058-1066

  Fuzesi T ^a   Sanchez E ^b   Wittmann, G ^a   Singru, P S ^b   Fekete, C ^a,b   Lechan, Ronald M ^b,c,d  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b Tupper Research Institute   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TUFTS MEDICAL CENTER   (United States)

Author keywords

Bacterial lipopolysaccharide; Cocaine and amphetamine regulated transcript; Dorsal vagal complex; Hypothalamic arcuate nucleus; Hypothalamic paraventricular nucleus; Retrograde tracing

Indexed keywords

CHOLERA TOXIN B SUBUNIT; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; AUTONOMIC INNERVATION; BRAIN NERVE CELL; CELL POPULATION; CONTROLLED STUDY; ENERGY METABOLISM; GENE EXPRESSION; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IN SITU HYBRIDIZATION; MALE; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; VAGUS NERVE DORSAL NUCLEUS;

ANIMALS; ANOREXIA; ENDOTOXINS; ENERGY METABOLISM; GENE EXPRESSION REGULATION; HOMEOSTASIS; LIPOPOLYSACCHARIDES; MALE; NERVE TISSUE PROTEINS; NEURONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RNA, MESSENGER;

EID: 49449090470     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2008.01758.x     Document Type: Article

References (35)

1. Douglass J, McKinzie AA, Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J. Neurosci 1995; 15: 2471-2481.
2. Couceyro PR, Koylu EO, Kuhar MJ. Further studies on the anatomical distribution of CART by in situ hybridization. J. Chem Neuroanat 1997; 12: 229-241.
3. Vrang N, Tang-Christensen M, Larsen PJ, Kristensen P. Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour. Brain Res 1999; 818: 499-509.
4. Lambert PD, Couceyro PR, McGirr KM, Dall Vechia SE, Smith Y, Kuhar MJ. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse 1998; 29: 293-298.
5. Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 1998; 393: 72-76.
6. Larsen PJ, Vrang N, Petersen PC, Kristensen P. Chronic intracerebroventricular administration of recombinant CART(42-89) peptide inhibits and causes weight loss in lean and obese Zucker (fa/fa) rats. Obes Res 2000; 8: 590-596.
7. Rohner-Jeanrenaud F, Craft LS, Bridwell J, Suter TM, Tinsley FC, Smiley DL, Burkhart DR, Statnick MA, Heiman ML, Ravussin E, Caro JF. Chronic central infusion of cocaine- and amphetamine-regulated transcript (CART 55-102): Effects on body weight homeostasis in lean and high-fat-fed obese rats. Int J Obes Relat Metab Disord 2002; 26: 143-149.
8. Scruggs P, Dun SL, Dun NJ. Cocaine- and amphetamine-regulated transcript peptide attenuates phenylephrine-induced bradycardia in anesthetized rats. Am J Physiol Regul Integr Comp Physiol 2003; 285: R1496-R1503.
9. Wang C, Billington CJ, Levine AS, Kotz CM. Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression. Neuroreport 2000; 11: 3251-3255.
10. Xia Y, Krukoff TL. Cardiovascular responses to subseptic doses of endotoxin contribute to differential neuronal activation in rat brain. Brain Res Mol Brain Res 2001; 89: 71-85.
11. Huang QH, Hruby VJ, Tatro JB. Role of central melanocortins in endotoxin-induced anorexia. Am J Physiol 1999; 276: R864-R871.
12. Sergeyev V, Broberger C, Hokfelt T. Effect of LPS administration on the expression of POMC, NPY, galanin, CART and MCH mRNAs in the rat hypothalamus. Brain Res Mol Brain Res 2001; 90: 93-100.
13. Rivest S, Laflamme N. Neuronal activity and neuropeptide gene transcription in the brains of immune-challenged rats. J. Neuroendocrinol 1995; 7: 501-525.
14. Koylu EO, Couceyro PR, Lambert PD, Ling NC, DeSouza EB, Kuhar MJ. Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J. Neuroendocrinol 1997; 9: 823-833.
15. Dyess EM, Segerson TP, Liposits Z, Paull WK, Kaplan MM, Wu P, Jackson IM, Lechan RM. Triiodothyronine exerts direct cell-specific regulation of thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus. Endocrinology 1988; 123: 2291-2297.
16. Kakucska I, Rand W, Lechan RM. Thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is dependent upon feedback regulation by both triiodothyronine and thyroxine. Endocrinology 1992; 130: 2845-2850.
17. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. San Diego, CA: Academic Press, 1998.
18. Sarkar S, Wittmann G, Fekete C, Lechan RM. Central administration of cocaine- and amphetamine-regulated transcript increases phosphorylation of cAMP response element binding protein in corticotropin-releasing hormone-producing neurons but not in prothyrotropin-releasing hormone-producing neurons in the hypothalamic paraventricular nucleus. Brain Res 2004; 999: 181-192.
19. Ericsson A, Kovacs KJ, Sawchenko PE. A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons. J. Neurosci 1994; 14: 897-913.
20. Rivest S, Lacroix S, Vallieres L, Nadeau S, Zhang J, Laflamme N. How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc Soc Exp Biol Med 2000; 223: 22-38.
21. Raptis S, Fekete C, Sarkar S, Rand WM, Emerson CH, Nagy GM, Lechan RM. Cocaine- and amphetamine-regulated transcript co-contained in thyrotropin-releasing hormone (TRH) neurons of the hypothalamic paraventricular nucleus modulates TRH-induced prolactin secretion. Endocrinology 2004; 145: 1695-1699.
22. Vrang N, Larsen PJ, Clausen JT, Kristensen P. Neurochemical characterization of hypothalamic cocaine- amphetamine-regulated transcript neurons. J. Neurosci 1999; 19: RC5.
23. Sanchez F, Fekete C, Lechan RM, Joseph-Bravo P. Cocaim and amphetamine-regulated transcript (CART) expression is differentially regulated in the hypothalamic paraventricular nucleus of lactating rats exposed to suckling or cold stimulation. Brain Res 2001; 1132: 120-128.
24. Kuriyama G, Takekoshi S, Tojo K, Nakai Y, Kuhar MJ, Osamura RY. Cocaine- and amphetamine-regulated transcript peptide in the rat anterior pituitary gland is localized in gonadotrophs and suppresses prolactin secretion. Endocrinology 2004; 145: 2542-2550.
25. Hollis JH, Lightman SL, Lowry CA. Lipopolysaccharide has selective actions on sub-populations of catecholaminergic neurons involved in activation of the hypothalamic-pituitary-adrenal axis and inhibition of prolactin secretion. J. Endocrinol 2005; 184: 393-406.
26. Thim L, Kristensen P, Nielsen PF, Wulff BS, Clausen JT. Tissue-specific processing of cocaine- and amphetamine-regulated transcript peptides in the rat. Proc Natl Acad Sci USA 1999; 96: 2722-2727.
27. Vrang N, Larsen PJ, Kristensen P, Tang-Christensen M. Central administration of cocaine-amphetamine-regulated transcript activates hypothalamic neuroendocrine neurons in the rat. Endocrinology 2000; 141: 794-801.
28. Stanley SA, Small CJ, Murphy KG, Rayes E, Abbott CR, Seal LJ, Morgan DG, Sunter D, Dakin CL, Kim MS, Hunter R, Kuhar M, Ghatei MA, Bloom SR. Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats. Brain Res 2001; 893: 186-194.
29. Smith SM, Vaughan JM, Donaldson CJ, Rivier J, Li C, Chen A, Vale WW. Cocaine- and amphetamine-regulated transcript activates the hypothalamic-pituitary-adrenal axis through a corticotropin-releasing factor receptor-dependent mechanism. Endocrinology 2004; 145: 5202-5209.
30. Molina-Holgado F, Guaza C. Endotoxin administration induced differential neurochemical activation of the rat brain stem nuclei. Brain Res Bull 1996; 40: 151-156.
31. Wiertelak EP, Roemer B, Maier SF, Watkins LR. Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias. Brain Res 1997; 748: 143-150.
32. Lacroix S, Rivest S. Functional circuitry in the brain of immune-challenged rats: Partial involvement of prostaglandins. J. Comp Neurol 1997; 387: 307-324.
33. Koylu EO, Couceyro PR, Lambert PD, Kuhar MJ. Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain. J. Comp Neurol 1998; 391: 115-132.
34. Zheng H, Patterson C, Berthoud HR. Fourth ventricular injection of CART peptide inhibits short-term sucrose intake in rats. Brain Res 2001; 896: 153-156.
35. Zheng H, Patterson LM, Berthoud HR. CART in the dorsal vagal complex: sources of immunoreactivity and effects on Fos expression and food intake. Brain Res 2002; 957: 298-310.