Cocaine- and amphetamine-regulated transcript peptide in the rat anterior pituitary gland is localized in gonadotrophs and suppresses prolactin secretion

Endocrinology

Volumn 145, Issue 5, 2004, Pages 2542-2550

  Kuriyama, Genshin ^a   Takekoshi, Susumu ^b   Tojo, Katsuyoshi ^a   Nakai, Yoshikatsu ^c   Kuhar, Michael J ^d   Osamura, R Yoshiyuki ^b  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKAI UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; PROLACTIN;

ADENOHYPOPHYSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL; PROLACTIN RELEASE; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RAT; REGULATORY MECHANISM;

ANIMALS; FOLLICLE STIMULATING HORMONE; GENE EXPRESSION; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LEPTIN; LUTEINIZING HORMONE; MALE; MICROSCOPY, IMMUNOELECTRON; NERVE TISSUE PROTEINS; PITUITARY GLAND; PROLACTIN; RATS; RATS, WISTAR; RNA, MESSENGER; SECRETORY VESICLES;

EID: 2042537973     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0845     Document Type: Article

References (36)

1. Douglass J, McKinzie AA, Couceyro P 1995 PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci 15:2471-2481
2. Douglass J, Daoud S 1996 Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript. Gene 169:241-245
3. Gautvik KM, De Lecea L, Gautvik VT, Danielson PE, Tranque P, Dopazo A, Bloom FE, Sutcliffe JG 1996 Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction. Proc Natl Acad Sci USA 93:8733-8738
4. Couceyro PR, Koylu EO, Kuhar MJ 1997 Further studies on the anatomical distribution of CART by in situ hybridization. J Chem Neuroanat 12:229-241
5. Jensen PB, Kristensen P, Clausen JT, Judge ME, Hastrup S, Thim L, Wulff BS, Foged C, Jensen J, Holst JJ, Madsen OD 1999 The hypothalamic satiety peptide CART is expressed in anorectic and nonanorectic pancreatic islet tumors and in the normal islet of Langerhans. FEBS Lett 447:139-143
6. Koylu EO, Couceyro PR, Lambert PD, Kuhar MJ 1998 Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain. J Comp Neurol 391:115-132
7. Koylu EO, Couceyro PR, Lambert PD, Ling NC, DeSouza EB, Kuhar MJ 1997 Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J Neuroendocrinol 9:823-833
8. Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S 1998 Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393:72-76
9. Kuhar MJ, Adams S, Dominguez G, Jaworski J, Balkan B2002CART peptides. Neuropeptides 36:1-8
10. Lebrethon MC, Vandersmissen E, Gerard A, Parent AS, Bourguignon JP 2000 Cocaine- and amphetamine-regulated-transcript peptide mediation of leptin stimulatory effect on the rat gonadotropin-releasing hormone pulse generator in vitro. J Neuroendocrinol 12:383-385
11. Christian Broberger 1999 Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin/hypocretin and neuropeptide Y. Brain Res 848:101-113
12. Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB, Elmquist JK 1998 Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21:1375-1385
13. Fekete C, Mihaly E, Luo LG, Kelly J, Clausen JT, Mao Q, Rand WM, Moss LG, Kuhar M, Emerson CH, Jackson IM, Lechan RM 2000 Association of cocaine- and amphetamine-regulated transcript-immunoreactive elements with thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and its role in the regulation of the hypothalamic-pituitary-thyroid axis during fasting. J Neurosci 20:9224-9234
14. Parent AS, Lebrethon MC, Gerard A, Vandersmissen E, Bourguignon JP 2000 Leptin effects on pulsatile gonadotropin releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine regulated transcript peptide and neuropeptide Y. Regul Pept 92:17-24
15. Stanley SA, Small CJ, Murphy KG, Rayes E, Abbott CR, Seal LJ, Morgan DGA, Sunter D, Dakin CL, Kim MS, Hunter R, Kuhar M, Ghatei MA, Bloom SR 2001 Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats. Brain Res 893:186-194
16. Lebrethon MC, Vandersmissen E, Gerard A, Parent AS, Junien JL, Bourguignon JP 2000 In vitro stimulation of the prepubertal rat gonadotropin-releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms. Endocrinology 141:1464-1469
17. Vrang N, Larsen PJ, Kristensen P, Tang-Christensen M 2000 Central administration of cocaine-amphetamine regulated transcript activates hypothalamic neuroendocrine neurons in the rat. Endocrinology 141:794-801
18. Murphy KG, Abbott CR, Mahmoudi M, Hunter R, Gardiner JV, Rossi M, Stanley SA, Ghatei MA, Kuhar MJ, Bloom SR 2000 Quantification and synthesis of cocaine- and amphetamine-regulated transcript peptide (79-102)-like immunoreactivity and mRNA in rat tissues. J Endocrinol 166:659-668
19. Kuhar MJ, Yoho LL 1999 CART peptide analysis by Western blotting. Synapse 33:163-171
20. Stanley SA, Small CJ, Kim MS, Heath MM, Seal LJ, Russell SH, Ghatei MA, Bloom SR 1999 Agouti-related peptide (Agrp) stimulates the hypothalamo pituitary gonadal axis in vivo, in vitro in male rats. Endocrinology 140:5459-5462
21. Todd JF, Small CJ, Akinsanya KO, Stanley SA, Smith DM, Bloom SR 1998 Galanin is a paracrine inhibitor of gonadotroph function in the female rat. Endocrinology 139:4222-4229
22. Beak SA, Small CJ, Ilovaiskala I, Hurley JD, Ghatei MA, Bloom SR, Smith DM 1996 Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): characterization of binding sites for GLP-1 on α-TSH cells. Endocrinology 137:4130-4138
23. Childs GV, Unabia G, Lloyd J 1992 Recruitment and maturation of small subsets of luteinizing hormone gonadotropes during the oestrous cycle. Endocrinology 130:335-344
24. Wilfinger WW, Larsen WJ, Downs TR, Wilbur DJ 1984 An in vitro model for studies of intercellular communication in cultured rat anterior pituitary cells. Tissue Cell 16:483-497
25. Swanson LW 1998 Brain maps: structure of the rat brain. Amsterdam: Elsevier
26. Dall Vechia S, Lambert PD, Couceyro PC, Kuhar MJ, Smith Y 2000 CART peptide immunoreactivity in the hypothalamus and pituitary in monkeys: analysis of ultrastructural features and synaptic connections in the paraventricular nucleus. J Comp Neurol 416:291-308
27. Dey A, Xhu X, Carroll R, Turck CW, Stein J, Steiner DF 2003 Biological processing of the cocaine- and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3. J Biol Chem 278:15007-15014
28. Natasha AM, Claire G, Nira BJ 1998 Cellular distribution and gene regulation of estrogen receptors α and β in the rat pituitary gland. Endocrinology 139:3976-3983
29. Dominguez G, Lakatos A, Kuhar MJ 2002 Characterization of the cocaine- and amphetamine-regulated transcript (CART) peptide gene promotor and its activation by a cyclic AMP-dependent signaling pathway in GH3 cells. J Neurochem 80:885-893
30. Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjoorbaek C, Elmquist JK, Flier JS, Hollenberg AN 2001 Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest 107:111-120
31. Jin L, Zhang S, Burguera BG, Couce ME, Osamura RY, Kullg E, Lloyd RV 2000 Leptin and leptin receptor expression in rat and mouse pituitary cells. Endocrinology 141:333-339
32. Sone M, Nagata H, Takekoshi S, Osamura RY 2001 Expression and localization of leptin receptor in the normal rat pituitary gland. Cell Tissue Res 305:351-356
33. Yu WH, Kimura M, Walczewska A, Karanth S, McCann SM 1997 Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 94:1023-1028
34. Jin L, Burguera BG, Couce ME, Scheithauer BW, Lamsan J, Eberhardt NL, Kulig E, Lloyd RV 1999 Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation. J Clin Endocrinol Metab 84:2903-2911
35. Dieterich KD, Lehnert H 1998 Expression of leptin receptor mRNA and the long form splice variant in human anterior pituitary and pituitary adenoma. Exp Clin Endocrinol Diabetes 106:522-525
36. Iqbal J, Pompolo S, Considine RV, Clarke IJ 2000 Localization of leptin-receptor like immunoreactivity in the corticotropes, somatotropes, and gonadotropes in the ovine anterior pituitary. Endocrinology 141:1515-1520