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Volumn 22, Issue 6, 2008, Pages 1595-1604

Biotransformation of genistein and bisphenol A in cell lines used for screening endocrine disruptors

Author keywords

Bisphenol A; Cell lines; Endocrine disruptors; Genistein; HC11; HepG2; MCF7; Metabolism; Toxicology

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ENDOCRINE DISRUPTOR; GENISTEIN;

EID: 49349111264     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.06.013     Document Type: Article
Times cited : (29)

References (65)
  • 1
    • 33846854212 scopus 로고    scopus 로고
    • The chick embryo: an animal model for detection of the effects of hormonal compounds
    • Biau S., Bayle S., de Santa Barbara P., and Roig B. The chick embryo: an animal model for detection of the effects of hormonal compounds. Anal. Bioanal. Chem. 387 4 (2007) 1397-1403
    • (2007) Anal. Bioanal. Chem. , vol.387 , Issue.4 , pp. 1397-1403
    • Biau, S.1    Bayle, S.2    de Santa Barbara, P.3    Roig, B.4
  • 2
    • 31444453937 scopus 로고    scopus 로고
    • Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines
    • Brandon E.F., Bosch T.M., Deenen M.J., Levink R., van der Wal E., van Meerveld J.B., Bijl M., Beijnen J.H., Schellens J.H., and Meijerman I. Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines. Toxicol. Appl. Pharmacol. 211 1 (2006) 1-10
    • (2006) Toxicol. Appl. Pharmacol. , vol.211 , Issue.1 , pp. 1-10
    • Brandon, E.F.1    Bosch, T.M.2    Deenen, M.J.3    Levink, R.4    van der Wal, E.5    van Meerveld, J.B.6    Bijl, M.7    Beijnen, J.H.8    Schellens, J.H.9    Meijerman, I.10
  • 3
    • 0031831117 scopus 로고    scopus 로고
    • Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay
    • Breinholt V., and Larsen J.C. Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay. Chem. Res. Toxicol. 11 6 (1998) 622-629
    • (1998) Chem. Res. Toxicol. , vol.11 , Issue.6 , pp. 622-629
    • Breinholt, V.1    Larsen, J.C.2
  • 4
    • 18144386167 scopus 로고    scopus 로고
    • Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells
    • Brooks J.D., and Thompson L.U. Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells. J. Steroid. Biochem. Mol. Biol. 94 5 (2005) 461-467
    • (2005) J. Steroid. Biochem. Mol. Biol. , vol.94 , Issue.5 , pp. 461-467
    • Brooks, J.D.1    Thompson, L.U.2
  • 6
    • 33747893350 scopus 로고    scopus 로고
    • Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells
    • Buterin T., Koch C., and Naegeli H. Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis 27 8 (2006) 1567-1578
    • (2006) Carcinogenesis , vol.27 , Issue.8 , pp. 1567-1578
    • Buterin, T.1    Koch, C.2    Naegeli, H.3
  • 7
    • 21644477459 scopus 로고    scopus 로고
    • In vitro models in endocrine disruptor screening
    • Charles G.D. In vitro models in endocrine disruptor screening. ILAR J. 45 4 (2004) 494-501
    • (2004) ILAR J. , vol.45 , Issue.4 , pp. 494-501
    • Charles, G.D.1
  • 9
    • 0037968936 scopus 로고    scopus 로고
    • Inhibitory actions of genistein in human breast cancer (MCF-7) cells
    • Chen W.F., Huang M.H., Tzang C.H., Yang M., and Wong M.S. Inhibitory actions of genistein in human breast cancer (MCF-7) cells. Biochim. Biophys. Acta. 1638 2 (2003) 187-196
    • (2003) Biochim. Biophys. Acta. , vol.1638 , Issue.2 , pp. 187-196
    • Chen, W.F.1    Huang, M.H.2    Tzang, C.H.3    Yang, M.4    Wong, M.S.5
  • 10
    • 34247134655 scopus 로고    scopus 로고
    • Preliminary studies on induction of apoptosis by genistein on HepG2 cell line
    • Chodon D., Ramamurty N., and Sakthisekaran D. Preliminary studies on induction of apoptosis by genistein on HepG2 cell line. Toxicol. In Vitro 21 5 (2007) 887-891
    • (2007) Toxicol. In Vitro , vol.21 , Issue.5 , pp. 887-891
    • Chodon, D.1    Ramamurty, N.2    Sakthisekaran, D.3
  • 12
    • 0031740852 scopus 로고    scopus 로고
    • Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice
    • Constantinou A.I., Krygier A.E., and Mehta R.R. Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice. Am. J. Clin. Nutr. 68 Suppl 6 (1998) 1426S-1430S
    • (1998) Am. J. Clin. Nutr. , vol.68 , Issue.SUPPL. 6
    • Constantinou, A.I.1    Krygier, A.E.2    Mehta, R.R.3
  • 13
    • 0027327501 scopus 로고
    • Development of a simple incubation system for metabolism studies with precision-cut liver slices
    • Dogterom P. Development of a simple incubation system for metabolism studies with precision-cut liver slices. Drug. Metab. Dispos. 21 4 (1993) 699-704
    • (1993) Drug. Metab. Dispos. , vol.21 , Issue.4 , pp. 699-704
    • Dogterom, P.1
  • 14
    • 0028863043 scopus 로고
    • Quantitative differences in phase I and II metabolism between rat precision-cut liver slices and isolated hepatocytes
    • Ekins S., Murray G.I., Burke M.D., Williams J.A., Marchant N.C., and Hawksworth G.M. Quantitative differences in phase I and II metabolism between rat precision-cut liver slices and isolated hepatocytes. Drug. Metab. Dispos. 23 11 (1995) 1274-1279
    • (1995) Drug. Metab. Dispos. , vol.23 , Issue.11 , pp. 1274-1279
    • Ekins, S.1    Murray, G.I.2    Burke, M.D.3    Williams, J.A.4    Marchant, N.C.5    Hawksworth, G.M.6
  • 15
    • 0029788511 scopus 로고    scopus 로고
    • Xenobiotic metabolism in rat, dog, and human precision-cut liver slices, freshly isolated hepatocytes, and vitrified precision-cut liver slices
    • Ekins S., Williams J.A., Murray G.I., Burke M.D., Marchant N.C., Engeset J., and Hawksworth G.M. Xenobiotic metabolism in rat, dog, and human precision-cut liver slices, freshly isolated hepatocytes, and vitrified precision-cut liver slices. Drug. Metab. Dispos. 24 9 (1996) 990-995
    • (1996) Drug. Metab. Dispos. , vol.24 , Issue.9 , pp. 990-995
    • Ekins, S.1    Williams, J.A.2    Murray, G.I.3    Burke, M.D.4    Marchant, N.C.5    Engeset, J.6    Hawksworth, G.M.7
  • 16
    • 0037165568 scopus 로고    scopus 로고
    • Characterization of isoflavones and their conjugates in female rat urine using LC/MS/MS
    • Fang N., Yu S., and Badger T.M. Characterization of isoflavones and their conjugates in female rat urine using LC/MS/MS. J. Agric. Food. Chem. 50 9 (2002) 2700-2707
    • (2002) J. Agric. Food. Chem. , vol.50 , Issue.9 , pp. 2700-2707
    • Fang, N.1    Yu, S.2    Badger, T.M.3
  • 17
    • 0442279183 scopus 로고    scopus 로고
    • Estrogen receptor functional activity changes during differentiation of mammary epithelial cells
    • Faulds M.H., Olsen H., Helguero L.A., Gustafsson J.A., and Haldosen L.A. Estrogen receptor functional activity changes during differentiation of mammary epithelial cells. Mol. Endocrinol. 18 2 (2004) 412-421
    • (2004) Mol. Endocrinol. , vol.18 , Issue.2 , pp. 412-421
    • Faulds, M.H.1    Olsen, H.2    Helguero, L.A.3    Gustafsson, J.A.4    Haldosen, L.A.5
  • 18
    • 5344220954 scopus 로고    scopus 로고
    • OECD test strategies and methods for endocrine disruptors
    • Gelbke H.P., Kayser M., and Poole A. OECD test strategies and methods for endocrine disruptors. Toxicology 205 1-2 (2004) 17-25
    • (2004) Toxicology , vol.205 , Issue.1-2 , pp. 17-25
    • Gelbke, H.P.1    Kayser, M.2    Poole, A.3
  • 21
    • 0035860643 scopus 로고    scopus 로고
    • Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens
    • Gutendorf B., and Westendorf J. Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology 166 1-2 (2001) 79-89
    • (2001) Toxicology , vol.166 , Issue.1-2 , pp. 79-89
    • Gutendorf, B.1    Westendorf, J.2
  • 22
    • 33746043754 scopus 로고    scopus 로고
    • Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells
    • Harrington W.R., Sengupta S., and Katzenellenbogen B.S. Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells. Endocrinology 147 8 (2006) 3843-3850
    • (2006) Endocrinology , vol.147 , Issue.8 , pp. 3843-3850
    • Harrington, W.R.1    Sengupta, S.2    Katzenellenbogen, B.S.3
  • 23
    • 0034819391 scopus 로고    scopus 로고
    • Measurement of estrogenic activity of chemicals for the development of new dental polymers
    • Hashimoto Y., Moriguchi Y., Oshima H., Kawaguchi M., Miyazaki K., and Nakamura M. Measurement of estrogenic activity of chemicals for the development of new dental polymers. Toxicol. In Vitro 15 4-5 (2001) 421-425
    • (2001) Toxicol. In Vitro , vol.15 , Issue.4-5 , pp. 421-425
    • Hashimoto, Y.1    Moriguchi, Y.2    Oshima, H.3    Kawaguchi, M.4    Miyazaki, K.5    Nakamura, M.6
  • 24
    • 27144524273 scopus 로고    scopus 로고
    • Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11
    • Helguero L.A., Faulds M.H., Gustafsson J.A., and Haldosen L.A. Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene 24 44 (2005) 6605-6616
    • (2005) Oncogene , vol.24 , Issue.44 , pp. 6605-6616
    • Helguero, L.A.1    Faulds, M.H.2    Gustafsson, J.A.3    Haldosen, L.A.4
  • 25
    • 1842627852 scopus 로고    scopus 로고
    • Phase I and II enzyme characterization of two sources of HepG2 cell lines
    • Hewitt N.J., and Hewitt P. Phase I and II enzyme characterization of two sources of HepG2 cell lines. Xenobiotica 34 3 (2004) 243-256
    • (2004) Xenobiotica , vol.34 , Issue.3 , pp. 243-256
    • Hewitt, N.J.1    Hewitt, P.2
  • 26
    • 0033384264 scopus 로고    scopus 로고
    • Differential interactions of bisphenol A and 17beta-estradiol with estrogen receptor alpha (ERalpha) and ERbeta
    • Hiroi H., Tsutsumi O., Momoeda M., Takai Y., Osuga Y., and Taketani Y. Differential interactions of bisphenol A and 17beta-estradiol with estrogen receptor alpha (ERalpha) and ERbeta. Endocr. J. 46 6 (1999) 773-778
    • (1999) Endocr. J. , vol.46 , Issue.6 , pp. 773-778
    • Hiroi, H.1    Tsutsumi, O.2    Momoeda, M.3    Takai, Y.4    Osuga, Y.5    Taketani, Y.6
  • 27
    • 49349084983 scopus 로고    scopus 로고
    • Holmes, P., Humfrey C., Scullion M., 2001.Appraisal of test methods for sex hormone dirupting chemicals. OECD Environmental Health and Safety publications. Series on Testing and Assessment no.21, Paris. ENV/JM/MONO(2002)8 .).
    • Holmes, P., Humfrey C., Scullion M., 2001.Appraisal of test methods for sex hormone dirupting chemicals. OECD Environmental Health and Safety publications. Series on Testing and Assessment no.21, Paris. ENV/JM/MONO(2002)8 .).
  • 28
    • 2942529395 scopus 로고    scopus 로고
    • Genistein enhances expression of genes involved in fatty acid catabolism through-activation of PPARalpha
    • Kim S., Shin H.J., Kim S.Y., Kim J.H., Lee Y.S., Kim D.H., and Lee M.O. Genistein enhances expression of genes involved in fatty acid catabolism through-activation of PPARalpha. Mol. Cell. Endocrinol. 220 1-2 (2004) 51-58
    • (2004) Mol. Cell. Endocrinol. , vol.220 , Issue.1-2 , pp. 51-58
    • Kim, S.1    Shin, H.J.2    Kim, S.Y.3    Kim, J.H.4    Lee, Y.S.5    Kim, D.H.6    Lee, M.O.7
  • 29
    • 14344264789 scopus 로고    scopus 로고
    • Interactions of phytoestrogens with estrogen receptors alpha and beta (III). Estrogenic activities of soy isoflavone aglycones and their metabolites isolated from human urine
    • Kinjo J., Tsuchihashi R., Morito K., Hirose T., Aomori T., Nagao T., Okabe H., Nohara T., and Masamune Y. Interactions of phytoestrogens with estrogen receptors alpha and beta (III). Estrogenic activities of soy isoflavone aglycones and their metabolites isolated from human urine. Biol. Pharm. Bull. 27 2 (2004) 185-188
    • (2004) Biol. Pharm. Bull. , vol.27 , Issue.2 , pp. 185-188
    • Kinjo, J.1    Tsuchihashi, R.2    Morito, K.3    Hirose, T.4    Aomori, T.5    Nagao, T.6    Okabe, H.7    Nohara, T.8    Masamune, Y.9
  • 30
    • 0019313649 scopus 로고
    • A new instrument for the rapid preparation of tissue slices
    • Krumdieck C.L., dos Santos J.E., and Ho K.J. A new instrument for the rapid preparation of tissue slices. Anal. Biochem. 104 1 (1980) 118-123
    • (1980) Anal. Biochem. , vol.104 , Issue.1 , pp. 118-123
    • Krumdieck, C.L.1    dos Santos, J.E.2    Ho, K.J.3
  • 31
    • 0031039888 scopus 로고    scopus 로고
    • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    • Kuiper G.G., Carlsson B., Grandien K., Enmark E., Haggblad J., Nilsson S., and Gustafsson J.A. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138 3 (1997) 863-870
    • (1997) Endocrinology , vol.138 , Issue.3 , pp. 863-870
    • Kuiper, G.G.1    Carlsson, B.2    Grandien, K.3    Enmark, E.4    Haggblad, J.5    Nilsson, S.6    Gustafsson, J.A.7
  • 34
    • 0342592133 scopus 로고    scopus 로고
    • Estrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters
    • Leffers H., Naesby M., Vendelbo B., Skakkebaek N.E., and Jorgensen M. Estrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters. Hum.Reprod. 16 5 (2001) 1037-1045
    • (2001) Hum.Reprod. , vol.16 , Issue.5 , pp. 1037-1045
    • Leffers, H.1    Naesby, M.2    Vendelbo, B.3    Skakkebaek, N.E.4    Jorgensen, M.5
  • 35
    • 0029119281 scopus 로고
    • Regulation of sex hormone-binding globulin production by isoflavonoids and patterns of isoflavonoid conjugation in HepG2 cell cultures
    • Loukovaara M., Carson M., Palotie A., and Adlercreutz H. Regulation of sex hormone-binding globulin production by isoflavonoids and patterns of isoflavonoid conjugation in HepG2 cell cultures. Steroids 60 9 (1995) 656-661
    • (1995) Steroids , vol.60 , Issue.9 , pp. 656-661
    • Loukovaara, M.1    Carson, M.2    Palotie, A.3    Adlercreutz, H.4
  • 36
    • 0034861836 scopus 로고    scopus 로고
    • Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells
    • Maggiolini M., Bonofiglio D., Marsico S., Panno M.L., Cenni B., Picard D., and Ando S. Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol. Pharmacol. 60 3 (2001) 595-602
    • (2001) Mol. Pharmacol. , vol.60 , Issue.3 , pp. 595-602
    • Maggiolini, M.1    Bonofiglio, D.2    Marsico, S.3    Panno, M.L.4    Cenni, B.5    Picard, D.6    Ando, S.7
  • 37
    • 18144392303 scopus 로고    scopus 로고
    • Comparative study of estrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells
    • Matsumura A., Ghosh A., Pope G.S., and Darbre P.D. Comparative study of estrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells. J. Steroid. Biochem. Mol. Biol. 94 5 (2005) 431-443
    • (2005) J. Steroid. Biochem. Mol. Biol. , vol.94 , Issue.5 , pp. 431-443
    • Matsumura, A.1    Ghosh, A.2    Pope, G.S.3    Darbre, P.D.4
  • 38
    • 0035102123 scopus 로고    scopus 로고
    • In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta
    • Matthews J.B., Twomey K., and Zacharewski T.R. In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta. Chem. Res. Toxico. 14 2 (2001) 149-157
    • (2001) Chem. Res. Toxico. , vol.14 , Issue.2 , pp. 149-157
    • Matthews, J.B.1    Twomey, K.2    Zacharewski, T.R.3
  • 39
    • 1542327639 scopus 로고    scopus 로고
    • Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs
    • Murata M., Midorikawa K., Koh M., Umezawa K., and Kawanishi S. Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs. Biochemistry 43 9 (2004) 2569-2577
    • (2004) Biochemistry , vol.43 , Issue.9 , pp. 2569-2577
    • Murata, M.1    Midorikawa, K.2    Koh, M.3    Umezawa, K.4    Kawanishi, S.5
  • 40
    • 0037138489 scopus 로고    scopus 로고
    • Metabolism of 2-hydroxy-4-mthoxybenzophenone in isolated rat hepatocytes and xenoestrogenic effects of its metabolites on MCF-7 human breast cancer cells
    • Nakagawa Y., and Suzuki T. Metabolism of 2-hydroxy-4-mthoxybenzophenone in isolated rat hepatocytes and xenoestrogenic effects of its metabolites on MCF-7 human breast cancer cells. Chem. Biol. Interact. 139 (2002) 115-128
    • (2002) Chem. Biol. Interact. , vol.139 , pp. 115-128
    • Nakagawa, Y.1    Suzuki, T.2
  • 41
    • 49349109502 scopus 로고    scopus 로고
    • OECD. The use of metabolising systems for in vitro testing of endocrine disruptors (www.oecd.org), 2006.
    • OECD. The use of metabolising systems for in vitro testing of endocrine disruptors (www.oecd.org), 2006.
  • 43
    • 0028818410 scopus 로고
    • Precision-cut tissue slices: applications in pharmacology and toxicology
    • Parrish A.R., Gandolfi A.J., and Brendel K. Precision-cut tissue slices: applications in pharmacology and toxicology. Life Sci. 57 21 (1995) 1887-1901
    • (1995) Life Sci. , vol.57 , Issue.21 , pp. 1887-1901
    • Parrish, A.R.1    Gandolfi, A.J.2    Brendel, K.3
  • 44
    • 4043076245 scopus 로고    scopus 로고
    • Effect of bisphenol A on drug metabolising enzymes in rat hepatic microsomes and precision-cut rat liver slices
    • Pfeiffer E., and Metzler M. Effect of bisphenol A on drug metabolising enzymes in rat hepatic microsomes and precision-cut rat liver slices. Arch. Toxicol. 78 7 (2004) 369-377
    • (2004) Arch. Toxicol. , vol.78 , Issue.7 , pp. 369-377
    • Pfeiffer, E.1    Metzler, M.2
  • 45
    • 26844495001 scopus 로고    scopus 로고
    • Survey and assessment of mammalian estrogen biological assays for hazard characterization
    • Reel J.R., Lamb J.C., and Neal B.H. Survey and assessment of mammalian estrogen biological assays for hazard characterization. Fund. Appl. Toxicol. 34 2 (1996) 288-305
    • (1996) Fund. Appl. Toxicol. , vol.34 , Issue.2 , pp. 288-305
    • Reel, J.R.1    Lamb, J.C.2    Neal, B.H.3
  • 46
    • 0036757326 scopus 로고    scopus 로고
    • Estrogenic effect of a series of bisphenol analogues on gene and protein expression in MCF-7 breast cancer cells
    • Rivas A., Lacroix M., Olea-Serrano F., Laios I., Leclercq G., and Olea N. Estrogenic effect of a series of bisphenol analogues on gene and protein expression in MCF-7 breast cancer cells. J. Steroid. Biochem. Mol. Biol. 82 1 (2002) 45-53
    • (2002) J. Steroid. Biochem. Mol. Biol. , vol.82 , Issue.1 , pp. 45-53
    • Rivas, A.1    Lacroix, M.2    Olea-Serrano, F.3    Laios, I.4    Leclercq, G.5    Olea, N.6
  • 49
    • 0036801744 scopus 로고    scopus 로고
    • Sulfation of bisphenol A abolished its estrogenicity based on proliferation and gene expression in human breast cancer MCF-7 cells
    • Shimizu M., Ohta K., Matsumoto Y., Fukuoka M., Ohno Y., and Ozawa S. Sulfation of bisphenol A abolished its estrogenicity based on proliferation and gene expression in human breast cancer MCF-7 cells. Toxicol. In Vitro 16 5 (2002) 549-556
    • (2002) Toxicol. In Vitro , vol.16 , Issue.5 , pp. 549-556
    • Shimizu, M.1    Ohta, K.2    Matsumoto, Y.3    Fukuoka, M.4    Ohno, Y.5    Ozawa, S.6
  • 51
    • 24944498888 scopus 로고    scopus 로고
    • Differential subcellular distribution of estrogen receptor isoforms: localization of ERalpha in the nucleoli and ERbeta in the mitochondria of human osteosarcoma SaOS-2 and hepatocarcinoma HepG2 cell lines
    • Solakidi S., Psarra A.M., and Sekeris C.E. Differential subcellular distribution of estrogen receptor isoforms: localization of ERalpha in the nucleoli and ERbeta in the mitochondria of human osteosarcoma SaOS-2 and hepatocarcinoma HepG2 cell lines. Biochim. Biophys. Acta. 1745 3 (2005) 382-392
    • (2005) Biochim. Biophys. Acta. , vol.1745 , Issue.3 , pp. 382-392
    • Solakidi, S.1    Psarra, A.M.2    Sekeris, C.E.3
  • 52
    • 0022263028 scopus 로고
    • The role of estrogens on the proliferation of human breast tumor cells (MCF-7)
    • Soto A.M., and Sonnenschein C. The role of estrogens on the proliferation of human breast tumor cells (MCF-7). J. Steroid. Biochem. 23 1 (1985) 87-94
    • (1985) J. Steroid. Biochem. , vol.23 , Issue.1 , pp. 87-94
    • Soto, A.M.1    Sonnenschein, C.2
  • 53
    • 0028818201 scopus 로고
    • The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants
    • Soto A.M., Sonnenschein C., Chung K.L., Fernandez M.F., Olea N., and Serrano F.O. The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ. Health Perspect. 103 Suppl 7 (1995) 13-22
    • (1995) Environ. Health Perspect. , vol.103 , Issue.SUPPL. 7 , pp. 13-22
    • Soto, A.M.1    Sonnenschein, C.2    Chung, K.L.3    Fernandez, M.F.4    Olea, N.5    Serrano, F.O.6
  • 56
    • 0034811222 scopus 로고    scopus 로고
    • An in vitro reporter gene assay method incorporating metabolic activation with human and rat S9 or liver microsomes
    • Sumida K., Ooe N., Nagahori H., Saito K., Isobe N., Kaneko H., and Nakatsuka I. An in vitro reporter gene assay method incorporating metabolic activation with human and rat S9 or liver microsomes. Biochem. Biophys. Res. Commun. 280 1 (2001) 85-91
    • (2001) Biochem. Biophys. Res. Commun. , vol.280 , Issue.1 , pp. 85-91
    • Sumida, K.1    Ooe, N.2    Nagahori, H.3    Saito, K.4    Isobe, N.5    Kaneko, H.6    Nakatsuka, I.7
  • 58
    • 36148955117 scopus 로고    scopus 로고
    • Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells
    • Westerink W.M., and Schoonen W.G. Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicol. In Vitro. (2007)
    • (2007) Toxicol. In Vitro.
    • Westerink, W.M.1    Schoonen, W.G.2
  • 59
    • 36148955117 scopus 로고    scopus 로고
    • Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells
    • Westerink W.M., and Schoonen W.G. Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicol. In Vitro. (2007)
    • (2007) Toxicol. In Vitro.
    • Westerink, W.M.1    Schoonen, W.G.2
  • 60
    • 0042065286 scopus 로고    scopus 로고
    • Influence of culture time on the expression of drug-metabolizing enzymes in primary human hepatocytes and hepatoma cell line HepG2
    • Wilkening S., and Bader A. Influence of culture time on the expression of drug-metabolizing enzymes in primary human hepatocytes and hepatoma cell line HepG2. J. Biochem. Mol. Toxicol. 17 4 (2003) 207-213
    • (2003) J. Biochem. Mol. Toxicol. , vol.17 , Issue.4 , pp. 207-213
    • Wilkening, S.1    Bader, A.2
  • 61
    • 0034859039 scopus 로고    scopus 로고
    • Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements
    • Yoon K., Pallaroni L., Stoner M., Gaido K., and Safe S. Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements. J. Steroid. Biochem. Mol. Biol. 78 1 (2001) 25-32
    • (2001) J. Steroid. Biochem. Mol. Biol. , vol.78 , Issue.1 , pp. 25-32
    • Yoon, K.1    Pallaroni, L.2    Stoner, M.3    Gaido, K.4    Safe, S.5
  • 62
    • 0034905363 scopus 로고    scopus 로고
    • Metabolic activation of bisphenol A by rat liver S9 fraction
    • Yoshihara S., Makishima M., Suzuki N., and Ohta S. Metabolic activation of bisphenol A by rat liver S9 fraction. Toxicol. Sci. 62 2 (2001) 221-227
    • (2001) Toxicol. Sci. , vol.62 , Issue.2 , pp. 221-227
    • Yoshihara, S.1    Makishima, M.2    Suzuki, N.3    Ohta, S.4
  • 63
    • 1542791534 scopus 로고    scopus 로고
    • Potent estrogenic metabolites of bisphenol A and bisphenol B formed by rat liver S9 fraction: their structures and estrogenic potency
    • Yoshihara S., Mizutare T., Makishima M., Suzuki N., Fujimoto N., Igarashi K., and Ohta S. Potent estrogenic metabolites of bisphenol A and bisphenol B formed by rat liver S9 fraction: their structures and estrogenic potency. Toxicol. Sci. 78 1 (2004) 50-59
    • (2004) Toxicol. Sci. , vol.78 , Issue.1 , pp. 50-59
    • Yoshihara, S.1    Mizutare, T.2    Makishima, M.3    Suzuki, N.4    Fujimoto, N.5    Igarashi, K.6    Ohta, S.7
  • 65
    • 0345073634 scopus 로고    scopus 로고
    • Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice
    • Zalko D., Soto A.M., Dolo L., Dorio C., Rathahao E., Debrauwer L., Faure R., and Cravedi J.P. Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice. Environ. Health Perspect. 111 3 (2003) 309-319
    • (2003) Environ. Health Perspect. , vol.111 , Issue.3 , pp. 309-319
    • Zalko, D.1    Soto, A.M.2    Dolo, L.3    Dorio, C.4    Rathahao, E.5    Debrauwer, L.6    Faure, R.7    Cravedi, J.P.8


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