The use and toxicity of steroids in the management of patients with brain metastases

Supportive Care in Cancer

Volumn 16, Issue 9, 2008, Pages 1041-1048

  Sturdza, Alina ^a   Millar, Barbara Ann ^a   Bana, Neelufer ^a   Laperriere, Normand ^a   Pond, Gregory ^b   Wong, Rebecca K S ^a   Bezjak, Andrea ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Brain metastases; Dexamethasone; Steroid use; Whole brain radiation therapy

Indexed keywords

DEXAMETHASONE; PREDNISONE; STEROID;

ADULT; ANKLE EDEMA; ANXIETY DISORDER; ARTICLE; BRAIN METASTASIS; CANCER RADIOTHERAPY; DEPRESSION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; FEMALE; GASTROINTESTINAL SYMPTOM; HICCUP; HUMAN; HYPERGLYCEMIA; INCREASED APPETITE; INFECTION COMPLICATION; INSOMNIA; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MOON FACE; MUSCLE WEAKNESS; NEUROLOGICAL COMPLICATION; PERIPHERAL EDEMA; PHYSICIAN; PRESCRIPTION; PRIORITY JOURNAL; PSYCHOSIS; RETROSPECTIVE STUDY; SIDE EFFECT; STEROID THERAPY; THRUSH; WEIGHT GAIN; WOUND HEALING IMPAIRMENT;

ADRENAL CORTEX HORMONES; ANTINEOPLASTIC AGENTS, HORMONAL; BRAIN NEOPLASMS; DATABASES AS TOPIC; DEXAMETHASONE; FEMALE; HUMANS; MALE; MIDDLE AGED; PHYSICIAN'S PRACTICE PATTERNS; QUESTIONNAIRES; RETROSPECTIVE STUDIES;

EID: 49349111000     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00520-007-0395-8     Document Type: Article

References (21)

1. M Bascuas SG Amares MT Machuca Munoz L Bascuas Asta 1985 Effect of dexamethasone at the level of cerebral metastases: evaluation by CT and nuclear medicine Rev Esp Oncol 32 539-542
2. A Bezjak 2001 Radiotherapy for brain metastases: defining palliative response Radiother Oncol 61 71 76
3. A Bezjak 2002 Symptom response after palliative radiotherapy for patients with brain metastases Eur J Cancer 38 487 496
4. JG Cairncross JH Kim JB Posner 1980 Radiation therapy for brain metastases Ann Neurol 7 529 41
5. Cairncross JG, Posner JB (1983) The management of brain metastases. In: Walker MD (ed) Oncology of the nervous system. vol. 12. Springer, Verlag, pp 342-377
6. JH Galicich LA French JC Melby 1961 Use of dexamethasone in the treatment of cerebral edema associated with brain Tumors Lancet 81 46
7. C Hempen E Weiss CF Hess 2002 Dexamethasone treatment in patients with brain metastases and primary brain tumors: do the benefits outweigh the side effects Support Care Cancer 10 322 328
8. PJ Hoskin J Crow HT Ford 1990 The influence of extent and local management on the outcome of radiotherapy for brain metastases Int J Radiat Oncol Biol Phys 19 111 115
9. FJ Lagerwaard 1991 Identification of prognostic factors in patients with brain metastases: a review of 1292 patients Int J Radiat Oncol Biol Phys 43 795 803
10. N Mackworth 1992 Quality of life self-reports from 200 brain tumor patients: comparison with Karnofsky performance scores J Neuro-Oncol 14 243 253
11. J Messer D Reitman HS Sacks H Smith Jr TC Chalmers 1983 Association of adrenocorticosteroid therapy and peptic-ulcer disease N Engl J Med 309 21 24
12. BM Millar A Bezjak M Tsao A Sturdza N Laperriere 2004 Defining the impact and contribution of steroids in patients receiving whole brain irradiation for cerebral metastases Clin Oncol 16 339 344
13. U Ito 1988 Formation and propagation of brain oedema fluid around human brain metastases: a CT study Acta Neurochir 90 35 41
14. AK Routh T Khansur BT Hickman D Bass 1994 Management of brain metastases: past, present and future South Med J 87 1218 1226
15. R Sawaya 2001 Consideration in the diagnosis and management of brain metastases Oncol 15 1144 1154
16. D Schiff 2001 Single brain metastases: current treatment options Neurol 3 89 99
17. R Soffietti 2002 Management of brain metastases J. Neurol. 249 1357 1369
18. Tikhtman AJ, Patchell RA (1994) Brain metastases. In: Morantz RA, Walsh JW (eds) Brain tumors. A comprehensive text. Marcel Dekker, New York, pp 553-566
19. J Vecht Ch A Hovestadt 1994 Dose-effect relationship of dexamethasone on Karnofsky performance in metastatic brain tumors Neurol 44 675 680
20. DE Weissman N Janjan 1991 Twice-daily tapering dexamethasone treatment during cranial radiation for newly diagnosed brain metastases J Neuro-Oncol 11 235 239
21. A Wolfson 1994 The role of steroids in the management of metastatic carcinoma to the brain Am J Clin Oncol 17 234 238