Challenges in HbA1c analysis and reporting: An interesting case illustrating the many pitfalls

Clinical Biochemistry

Volumn 41, Issue 13, 2008, Pages 1104-1106

  Higgins, Trefor ^a   Stewart, Debbie ^a   Boehr, Eugene ^b  

^a DynaLIFE Dx   (Canada)

^b Chinook Regional Hospital   (Canada)

Author keywords

Glycated species; HbA1c; Homozygous HbS

Indexed keywords

GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C; HEMOGLOBIN F; HYDROXYUREA;

ADULT; ARTICLE; CASE REPORT; CELL SURVIVAL; GENETIC VARIABILITY; GLYCATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOZYGOSITY; HUMAN; IMMUNOASSAY; MALE; METHODOLOGY; PRIORITY JOURNAL; SICKLE CELL ANEMIA;

ANEMIA, SICKLE CELL; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FALSE NEGATIVE REACTIONS; FETAL HEMOGLOBIN; HEMOGLOBIN A, GLYCOSYLATED; HEMOGLOBIN, SICKLE; HOMOZYGOTE; HUMANS; IMMUNOASSAY; MALE;

EID: 49349109649     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2008.06.005     Document Type: Article

References (11)

1. Sacks D.B., Bruns D.E., Goldstein D.E., Maclaren N.K., McDonald J.M., and Parrott M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 48 (2002) 436-472
2. Clinical Practice Guidelines Committees. Canadian Diabetes Association 2003 clinical practice guidelines for the prevention and management of diabetes in Canada. Can J Diabetes 27 (2003) S21-S23
3. 1c: a 6 year progress report. Clin Chem 54 (2008) 240-248
4. 1c and possible interference. Clin Chem 41 (1995) 658-663
5. Sacks D.B. Hemoglobin variants and hemoglobin A1c analysis: problem solved?. Clin Chem 49 (2003) 1245-1247
6. 1c measurements. Clin Biochemistry 41 (2008) 88-90
7. 1c methods compared with the IFCC reference method. Am J Clin Path 129 (2008) 811-814
8. Karsegard J., Wicky J., Mensi N., Caulfield A., and Phillipe J. Spurious glycohemoglobin values associated with hydroxyurea treatment. Diabetes Care 20 (1997) 211-212
9. Bain B.J. Sickle cell hemoglobin and its interactions with other variant hemoglobins and with thalassemias. Haemoglobinopathy diagnosis (2001), Blackwell Science, Malden, MA 113-153
10. McCurdy P.R., and Sherman A.S. Irreversibly sickled cells and the red cell survival in sickle cell anemia: a study with both DF32P and 51CR. Amer J Med 64 (1978) 253-258
11. Cowie C.C., Rust K.F., Byrd-Holt D.D., Eberhardt M.S., Flegal K.M., Engelgau M.M., et al. Prevalence of diabetes and impaired fasting glucose in adults in the US population. Diabetes Care 29 (2006) 1263-1268