Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability

Neuroscience

Volumn 155, Issue 2, 2008, Pages 485-491

  Chen, G L ^a   Miller, G M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

5 HT; gene expression; nonhuman primate; nonsynonymous polymorphisms; TPH2

Indexed keywords

DNA; MESSENGER RNA; SEROTONIN; TRYPTOPHAN HYDROXYLASE 2;

ANIMAL CELL; ARTICLE; DNA DETERMINATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HAPLOTYPE; MUTANT; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; RAT; RHESUS MONKEY; RNA STABILITY; SINGLE NUCLEOTIDE POLYMORPHISM; WESTERN BLOTTING; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; HAPLOTYPES; MACACA MULATTA; MOLECULAR SEQUENCE DATA; NEURONS; NUCLEIC ACID CONFORMATION; PC12 CELLS; PHOSPHATIDYLETHANOLAMINES; POLYMORPHISM, SINGLE NUCLEOTIDE; RATS; RNA STABILITY; RNA, MESSENGER; TRYPTOPHAN HYDROXYLASE;

EID: 49349106191     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.05.050     Document Type: Article

References (40)

1. Barr C.S., Schwandt M., Lindell S.G., Chen S.A., Goldman D., Suomi S.J., Higley J.D., and Heilig M. Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques. Arch Gen Psychiatry 64 (2007) 369-376
2. Bond C., LaForge K.S., Tian M., Melia D., Zhang S., Borg L., Gong J., Schluger J., Strong J.A., Leal S.M., Tischfield J.A., Kreek M.J., and Yu L. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A 95 (1998) 9608-9613
3. Brown S.M., Peet E., Manuck S.B., Williamson D.E., Dahl R.E., Ferrell R.E., and Hariri A.R. A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol Psychiatry 10 (2005) 884-888
4. Canli T., Congdon E., Gutknecht L., Constable R.T., and Lesch K.P. Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J Neural Transm 112 (2005) 1479-1485
5. Capon F., Allen M.H., Ameen M., Burden A.D., Tillman D., Barker J.N., and Trembath R.C. A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups. Hum Mol Genet 13 (2004) 2361-2368
6. Cervo L., Canetta A., Calcagno E., Burbassi S., Sacchetti G., Caccia S., Fracasso C., Albani D., Forloni G., et al. Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression. J Neurosci 25 (2005) 8165-8172
7. Chen G.L., Vallender E.J., and Miller G.M. Functional characterization of the human TPH2 5′ regulatory region, untranslated region and polymorphisms modulate gene expression in vitro. Hum Genet 122 (2008) 645-657
8. Chen G.L., Novak M.A., Hakim S., Xie Z., and Miller G.M. Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys, association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression. Mol Psychiatry 11 (2006) 914-928
9. Cichon S., Winge I., Mattheisen M., Georgi A., Karpushova A., Freudenberg J., Freudenberg-Hua Y., Babadjanova G., Van Den Bogaert A., et al. Brain-specific tryptophan hydroxylase 2 (TPH2), a functional Pro206Ser substitution and variation in the 5′-region are associated with bipolar affective disorder. Hum Mol Genet 17 (2008) 87-97
10. Coon H., Dunn D., Lainhart J., Miller J., Hamil C., Battaglia A., Tancredi R., Leppert M.F., Weiss R., and McMahon W. Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). Am J Med Genet B Neuropsychiatr Genet 135 (2005) 42-46
11. Côté F., Thévenot E., Fligny C., Fromes Y., Darmon M., Ripoche M.A., Bayard E., Hanoun N., Saurini F., Lechat P., Dandolo L., Hamon M., Mallet J., and Vodjdani G. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc Natl Acad Sci U S A 100 (2003) 13525-13530
12. Crowley J.J., Blendy J.A., and Lucki I. Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test. Psychopharmacology (Berl) 183 (2005) 257-264
13. Duan J., Wainwright M.S., Comeron J.M., Saitou N., Sanders A.R., Gelernter J., and Gejman P.V. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 12 (2003) 205-216
14. Greene L.A., and Tischler A.S. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A 73 (1976) 2424-2428
15. Guhaniyogi J., and Brewer G. Regulation of mRNA stability in mammalian cells. Gene 265 (2001) 11-23
16. Gutknecht L., Jacob C., Strobel A., Kriegebaum C., Müller J., Zeng Y., Markert C., Escher A., Wendland J., Reif A., Mössner R., Gross C., Brocke B., and Lesch K.P. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. Int J Neuropsychopharmacol 10 (2007) 309-320
17. Herrmann M.J., Huter T., Müller F., Mühlberger A., Pauli P., Reif A., Renner T., Canli T., Fallgatter A.J., and Lesch K.P. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cereb Cortex 17 (2007) 1160-1163
18. Hong K.W., Sugawara Y., Hasegawa H., Hayasaka I., Hashimoto R., Ito S., and Inoue-Murayama M. A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats. Neurosci Lett 412 (2007) 195-200
19. Kroslak T., Laforge K.S., Gianotti R.J., Ho A., Nielsen D.A., and Kreek M.J. The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. J Neurochem 103 (2007) 77-87
20. Kulikov A.V., Osipova D.V., Naumenko V.S., and Popova N.K. Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains. Genes Brain Behav 4 (2005) 482-485
21. Lin Y.M., Chao S.C., Chen T.M., Lai T.J., Chen J.S., and Sun H.S. Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese. Arch Gen Psychiatry 64 (2007) 1015-1024
22. Lopez V.A., Detera-Wadleigh S., Cardona I., Kassem L., McMahon F.J., and The National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium. Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts. Biol Psychiatry 61 (2007) 181-186
23. Miller G.M., Bendor J., Tiefenbacher S., Yang H., Novak M.A., and Madras B.K. A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggression. Mol Psychiatry 9 (2004) 99-108
24. Nackley A.G., Shabalina S.A., Tchivileva I.E., Satterfield K., Korchynskyi O., Makarov S.S., Maixner W., and Diatchenko L. Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 314 (2006) 1930-1933
25. Nielsen D.A., Barral S., Proudnikov D., Kellogg S., Ho A., Ott J., and Kreek M.J. TPH2 and TPH1: Association of variants and interactions with heroin addiction. Behav Genet 38 (2008) 133-150
26. Reuter M., Hennig J., Amelang M., Montag C., Korkut T., Hueweler A., and Stürmer T. The role of the TPH1 and TPH2 genes for nicotine dependence: a genetic association study in two different age cohorts. Neuropsychobiology 56 (2007) 47-54
27. Reuter M., Kuepper Y., and Hennig J. Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance. Int J Neuropsychopharmacol 10 (2007) 401-404
28. Scheuch K., Lautenschlager M., Grohmann M., Stahlberg S., Kirchheiner J., Zill P., Heinz A., Walther D.J., and Priller J. Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biol Psychiatry 62 (2007) 1288-1294
29. Sheehan K., Lowe N., Kirley A., Mullins C., Fitzgerald M., Gill M., and Hawi Z. Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD. Mol Psychiatry 10 (2005) 944-949
30. Tzvetkov M.V., Brockmöller J., Roots I., and Kirchheiner J. Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment. Pharmacogenet Genomics 18 (2008) 495-506
31. Vasilopoulos Y., Cork M.J., Teare D., Marinou I., Ward S.J., Duff G.W., and Tazi-Ahnini R. A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis. Allergy 62 (2007) 514-519
32. Walther D.J., and Bader M. A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 66 (2003) 1673-1680
33. Walther D.J., Peter J.U., Bashammakh S., Hortnagl H., Voits M., Fink H., and Bader M. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299 (2003) 76
34. Wang D., Johnson A.D., Papp A.C., Kroetz D.L., and Sadée W. Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenet Genomics 15 (2005) 693-704
35. Wolfe K.J., Wickliffe J.K., Hill C.E., Paolini M., Ammenheuser M.M., and Abdel-Rahman S.Z. Single nucleotide polymorphisms of the DNA repair gene XPD/ERCC2 alter mRNA expression. Pharmacogenet Genomics 17 (2007) 897-905
36. Xu H., Tian W., Fu Y., Oyama T.T., Anderson S., and Cohen D.M. Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene. Am J Physiol Renal Physiol 293 (2007) F1865-F1876
37. Zhang X., Beaulieu J.M., Sotnikova T.D., Gainetdinov R.R., and Caron M.G. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305 (2004) 217
38. Zhang X., Gainetdinov R.R., Beaulieu J.M., Sotnikova T.D., Burch L.H., Williams R.B., Schwartz D.A., Krishnan K.R., and Caron M.G. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45 (2005) 11-16
39. Zhang Y., Wang D., Johnson A.D., Papp A.C., and Sadée W. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J Biol Chem 280 (2005) 32618-32624
40. Zhou Z., Roy A., Lipsky R., Kuchipudi K., Zhu G., Taubman J., Enoch M.A., Virkkunen M., and Goldman D. Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Arch Gen Psychiatry 62 (2005) 1109-1118