Tryptophan hydroxylase 2 gene and alcohol use among college students

Addiction Biology

Volumn 13, Issue 3-4, 2008, Pages 440-448

  Gacek, Paul ^a   Conner, Tamlin S ^b   Tennen, Howard ^a   Kranzler, Henry R ^a   Covault, Jonathan ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b University of Otage   (New Zealand)

Author keywords

Alcohol; College drinking; Gene environment interaction; Heavy drinking; TPH2; Tryptophan hydroxylase

Indexed keywords

DNA;

ADULT; ALCOHOL CONSUMPTION; ALLELE; ARTICLE; COLLEGE STUDENT; DNA POLYMORPHISM; ENVIRONMENTAL STRESS; FEMALE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN GENOME; LIFE EVENT; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADOLESCENT; ALCOHOLISM; ALLELES; DNA PRIMERS; FEMALE; GENOTYPE; HUMANS; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; STUDENTS; TRYPTOPHAN HYDROXYLASE; UNIVERSITIES; YOUNG ADULT;

EID: 49349105958     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2008.00118.x     Document Type: Article

References (40)

1. Aiken LS, West SG (1991) Multiple Regression: Testing and Interpreting Interactions. Newbury Park, CA : Sage Publications.
2. Brown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE, Hariri AR (2005) A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol Psychiatry 10 : 884 888, 805.
3. Canli T, Congdon E, Gutknecht L, Constable RT, Lesch KP (2005) Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J Neural Transm 112 : 1479 1485.
4. Caspi A, Moffitt TE (2006) Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci 7 : 583 590.
5. Chung IW, Kim H, Sribney W, Hong JB, Lee CH, Lee KY, Nan HM, Kim YS, Manowitz P (2005) Tryptophan hydroxylase polymorphism is associated with age of onset of alcoholism related behaviors. Alcohol 36 : 1 3.
6. Clements K, Turpin G (1996) The life events scale for students: validation for use with British samples. Pers Individ Differ 20 : 747 751.
7. Cohen EGD, Uhlenbeck GE (1971) Statistical Mechanics at the Turn of the Decade. New York : M. Dekker.
8. Cote F, Fligny C, Bayard E, Launay JM, Gershon MD, Mallet J, Vodjdani G (2007) Maternal serotonin is crucial for murine embryonic development. Proc Natl Acad Sci USA 104 : 329 334.
9. Covault J, Tennen H, Armeli S, Conner TS, Herman AI, Cillessen AH, Kranzler HR (2007) Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biol Psychiatry 61 : 609 616.
10. Fehr C, Grintschuk N, Szegedi A, Anghelescu I, Klawe C, Singer P, Hiemke C, Dahmen N (2000) The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. Psychiatry Res 97 : 1 10.
11. Feinn R, Nellissery M, Kranzler HR (2005) Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 133 : 79 84.
12. Herman AI, Philbeck JW, Vasilopoulos NL, Depetrillo PB (2003) Serotonin transporter promoter polymorphism and differences in alcohol consumption behaviour in a college student population. Alcohol 38 : 446 449.
13. Herrmann MJ, Huter T, Muller F, Muhlberger A, Pauli P, Reif A, Renner T, Canli T, Fallgatter AJ, Lesch KP (2007) Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cereb Cortex 17 : 1160 1163.
14. Hu X, Oroszi G, Chun J, Smith TL, Goldman D, Schuckit MA (2005) An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res 29 : 8 16.
15. Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL, Murphy DL, Goldman D (2006) Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78 : 815 826.
16. Ishiguro H, Saito T, Shibuya H, Toru M, Arinami T (1999) The 5' region of the tryptophan hydroxylase gene: mutation search and association study with alcoholism. J Neural Transm 106 : 1017 1025.
17. Kaufman J, Yang BZ, Douglas-Palumberi H, Crouse-Artus M, Lipschitz D, Krystal JH, Gelernter J (2007) Genetic and environmental predictors of early alcohol use. Biol Psychiatry 61 : 1228 1234.
18. Khozhai LI, Otellin VA (2005) Neocortex formation in mice developing after prenatal serotonin depletion. Morfologiia 127 : 17 20.
19. Lappalainen J, Long JC, Eggert M, Ozaki N, Robin RW, Brown GL, Naukkarinen H, Virkkunen M, Linnoila M, Goldman D (1998) Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Arch Gen Psychiatry 55 : 989 994.
20. LeMarquand D, Pihl RO, Benkelfat C (1994) Serotonin and alcohol intake, abuse, and dependence: clinical evidence. Biol Psychiatry 36 : 326 337.
21. Li D, He L (2006) Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia. Hum Genet 120 : 22 30.
22. Linden W (1984) Development and initial validation of a life event scale for students. Canadian Counsellor 18 : 106 110.
23. McBride WJ, Lovinger DM, Machu T, Thielen RJ, Rodd ZA, Murphy JM, Roache JD, Johnson BA (2004) Serotonin-3 receptors in the actions of alcohol, alcohol reinforcement, and alcoholism. Alcohol Clin Exp Res 28 : 257 267.
24. Mohr CD, Armeli S, Tennen H, Temple M, Todd M, Clark J, Carney M (2005) Moving beyond the keg party: a daily process study of college student drinking. Psychol Addict Behav 19 : 392 403.
25. Mossner R, Walitza S, Geller F, Scherag A, Gutknecht L, Jacob C, Bogusch L, Remschmidt H, Simons M, Herpertz-Dahlmann B, Fleischhaker C, Schulz E, Warnke A, Hinney A, Wewetzer C, Lesch KP (2006) Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharmacol 9 : 437 442.
26. Nakamura K, Sugawara Y, Sawabe K, Ohashi A, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Nishimura H, Hasegawa H, Hirose S (2006) Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. J Neurosci 26 : 530 534.
27. Nakamura M, Ueno S, Sano A, Tanabe H (2000) The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry 5 : 32 38.
28. Naranjo CA, Sellers EM, Lawrin MO (1986) Modulation of ethanol intake by serotonin uptake inhibitors. J Clin Psychiatry 47 Suppl : 16 22.
29. Park CL, Armeli S, Tennen H (2004) Appraisal-coping goodness of fit: a daily internet study. Pers Soc Psychol B 30 : 558 569.
30. Sacco R, Papaleo V, Hager J, Rousseau F, Moessner R, Militerni R, Bravaccio C, Trillo S, Schneider C, Melmed R, Elia M, Curatolo P, Manzi B, Pascucci T, Puglisi-Allegra S, Reichelt KL, Persico AM (2007) Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. BMC Med Genet 8 : 11.
31. Scheuch K, Lautenschlager M, Grohmann M, Stahlberg S, Kirchheiner J, Zill P, Heinz A, Walther DJ, Priller J (2007) Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biol Psychiatry.
32. Stoltenberg SF, Glass JM, Chermack ST, Flynn HA, Li S, Weston ME, Burmeister M (2006) Possible association between response inhibition and a variant in the brain-expressed tryptophan hydroxylase-2 gene. Psychiatr Genet 16 : 35 38.
33. Sun HS, Fann CS, Lane HY, Chang YT, Chang CJ, Liu YL, Cheng AT (2005) A functional polymorphism in the promoter region of the tryptophan hydroxylase gene is associated with alcohol dependence in one aboriginal group in Taiwan. Alcohol Clin Exp Res 29 : 1 7.
34. Tennen H, Affleck G, Armeli S (2005) Personality and daily experience revisited. J Pers 73 : 1465 1483.
35. Virkkunen M, Linnoila M (1997) Serotonin in early-onset alcoholism. Recent Dev Alcohol 13 : 173 189.
36. Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, Bader M (2003) Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299 : 76.
37. Wechsler H, Dowdall GW, Davenport A, Castillo S (1995) Correlates of college student binge drinking. Am J Public Health 85 : 921 926.
38. Wechsler H, Lee JE, Kuo M, Seibring M, Nelson TF, Lee H (2002) Trends in college binge drinking during a period of increased prevention efforts. Findings from 4 Harvard School of Public Health College Alcohol Study surveys: 1993-2001. J Am Coll Health 50 : 203 217.
39. Zhang X, Gainetdinov RR, Beaulieu JM, Sotnikova TD, Burch LH, Williams RB, Schwartz DA, Krishnan KR, Caron MG (2005) Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45 : 11 16.
40. Zill P, Preuss UW, Koller G, Bondy B, Soyka M (2007) SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide. Neuropsychopharmacology.