p53 and BCL-2 as prognostic markers in endometrial carcinoma

Pathology and Oncology Research

Volumn 14, Issue 1, 2008, Pages 23-30

  Appel, Márcia L M ^a   Edelweiss, Maria I ^a   Fleck, James ^a   Rivero, Luis F ^a   Rivoire, Waldemar A ^a   Mônego, Heleusa I ^a   Dos Reis, Ricardo ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

BCL 2; Endometrial cancer; p53; Prognosis

Indexed keywords

PARAFFIN; PROTEIN BCL 2; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER PATIENT; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIUM CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MYOMETRIUM; PATIENT ASSESSMENT; PROTEIN EXPRESSION; UNIVARIATE ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; CARCINOMA, ENDOMETRIOID; CHI-SQUARE DISTRIBUTION; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 49349104302     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-008-9000-9     Document Type: Article

References (39)

1. Instituto Nacional do Câncer. (2006) Estimativas da Incidência e mortalidade por câncer no Brasil. 2003. http://www.inca.gov.br. Accessed May 2
2. Hacker NF (2000) Uterine cancer. In: Berek JS and Hacker NF (eds) Practical gynecologic oncology, 3rd ed. Lippincott Williams & Wilkins, Philadelphia, pp 407-456
3. LM Axtell MH Myers 1978 Contrasts in survival of black and white cancer patients J Natl Cancer Inst 60 1209 1215
4. RT Greenlee T Murray S Bolden PA Wingo 2000 Cancer statistics, 2000 CA Cancer J Clin 50 7 33
5. A Mariani TJ Sebo JA Katzmann GL Keeney PC Roche TG Lesnick KC Podratz 2000 Pretreatment assessment of prognostic indicators in endometrial cancer Am J Obstet Gynecol 182 1535 1544
6. T Ohkouchi N Sakuragi H Watari E Nomura Y Todo H Yamada S Fujimoto 2002 Prognostic significance of Bcl-2, p53 overexpression, and lymph node metastasis in surgically staged endometrial carcinoma Am J Obstet Gynecol 187 353 359
7. JP Geisler MD Wiemann Z Zhou GA Miller HE Geisler 1996 p53 as a prognostic indicator in endometrial cancer Gynecol Oncol 61 245 248
8. JP Geisler HE Geisler MD Wiemann Z Zhou GA Miller W Crabtree 1999 p53 expression as a prognostic indicator of 5-year survival in endometrial cancer Gynecol Oncol 74 468 471
9. JP Geisler HE Geisler MC Wiemann Z Zhou GA Miller W Crabtree 1998 Lack of bcl-2 persistence: an independent prognostic indicator of poor prognosis in endometrial carcinoma Gynecol Oncol 71 305 307
10. N Sakuragi T Ohkouchi H Hareyama K Ikeda H Watari T Fujimoto M Kuwabara R Yamamoto T Sagawa T Fujino S Fujimoto 1998 Bcl-2 expression and prognosis of patients with endometrial carcinoma Int J Cancer 79 153 158
11. H Nishioka Y Hiasa I Hayashi Y Kitahori N Konishi M Sugimura 1993 Immunohistochemical detection of p53 oncoprotein in human oral squamous cell carcinomas and leukoplasias: comparison with proliferating cell nuclear antigen staining and correlation with clinicopathological findings Oncology 50 426 429
12. S Kounelis N Kapranos E Kouri D Coppola H Papadaki M Jones 2000 Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature Mod Pathol 13 379 388
13. MF Kohler P Carney R Dodge J Soper DL Clarke-Pearson JR Marks A Berchuck 1996 p53 overexpression in advanced-stage endometrial adenocarcinoma Am J Obstet Gynecol 175 1246 1252
14. HM Morsi MP Leers M Radespiel-Tröger V Björklund HE Kabarity M Nap W Jäger 2000 Apoptosis, bcl-2 expression, and proliferation in benign and malignant endometrial epithelium: an approach using multiparameter flow cytometry Gynecol Oncol 77 11 17
15. M Marone G Ferrandina G Macchia S Mozzetti 2000 Bcl-2, Bax, Bcl-xl and Bcl-xs expression in neoplastic and normal endometrium Oncology 58 161 168
16. D Coppola L Fu SV Nicosia S Kounelis M Jones 1998 Prognostic significance of p53, bcl-2, vimentin, and S100 protein-positive Langerhans cells in endometrial carcinoma Human Pathol 29 455 462
17. N Yamauchi A Sakamoto H Uozaki K Iihara R Machinami 1996 Immunohistochemical analysis of endometrial adenocarcinoma for bcl-2 and p53 in relation to expression of sex steroid receptor and proliferative activity Int J Gynecol Pathol 15 202 208
18. M Taskin TA Lallas HR Barber MM Shevchuk 1997 bcl-2 and p53 endometrial adenocarcinoma Mod Pathol 10 728 734
19. M Saegusa I Okayasu 1997 Bcl-2 is closely correlated with favorable prognostic factors and inversely associated with p53 protein accumulation in endometrial carcinomas: immunohistochemical and polymerase chain reaction/loss of heterozygosity findings J Cancer Res Clin Oncol 123 429 434
20. College of American Pathologists (2006) http://www.cap.org. Home>reference and Publications> Cancer Protocols and Checklists. Accessed 22 May
21. A Giatromanolaki E Sivridis MI Koukourakis AL Harris KC Gatter 1998 Bcl-2 and p53 expression in stage I endometrial carcinoma Anticancer Res 18 3689 3694
22. HJ van Slooten MJ van der Vijver CJH van der Velde JH van Dierendonck 1998 Loss of Bcl-2 in invasive breast cancer is associated with high rates of cell death, but also with increased proliferative activity Br J Cancer 77 789 796
23. N Bonneefoy-Berard A Aouacheria C Verschelde L Quemeneur A Marçais J Marvel 2004 Control of proliferation by Bcl-2 family members Biochim Biophys Acta 1644 159 168
24. J Boyd 1996 Molecular biology in the clinicopathologic assessment of endometrial carcinoma subtypes-editorial Gynecol Oncol 61 163 165
25. RA Ambros ME Sherman CM Zahm P Bitterman RJ Kurman 1995 Endometrial intraepithelial carcinoma: a distinctive lesion specifically associated with tumors displaying serous differentiation Hum Pathol 26 1260 1267
26. ME Sherman ME Bur RJ Kurman 1995 p53 in endometrial cancer and its putative precursors: evidence for diverse pathways of tumorigenesis Hum Pathol 26 1268 1274
27. GW Spiegel 1995 Endometrial carcinoma in situ in postmenopausal women Am J Surg Pathol 19 417 432
28. JL Burton M Wells 1998 Recent advances in the histopathology and molecular pathology of carcinoma of the endometrium-review Histopathology 33 297 303
29. N Sakuragi A Hirai M Tada H Yamada R Yamamoto S Fujimoto 2001 Dominant-negative mutation of p53 tumor suppressor gene in endometrial carcinoma Gynecol Oncol 83 485 490
30. MF Kohler BJ Kerns PA Humprey JR Marks RC Bast A Berchuck 1993 Mutation and overexpression of p53 in early-stage epithelial ovarian cancer Obstet Gynecol 81 643 650
31. R Soong S Knowles KE Williams IG Hammond SJ Wysocki BJ Iacopetta 1996 Overexpression of p53 protein is an independent prognostic indicator in human endometrial carcinoma Br J Cancer 74 562 567
32. S Oreskovic D Babic D Kalafatic D Barisic LA Beketic-Oreskovic 2004 Significance of immunohistochemical determination of steroid receptors, cell proliferation factor Ki-67 and protein p53 in endometrial carcinoma Gynecol Oncol 93 34 40
33. H Tashiro C Isacson R Levine RJ Kurman KR Cho L Hedrick 1997 p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis Am J Pathol 150 177 185
34. T Miyashita S Krajewski M Krajewska HG Wang HK Lin DA Liebermann B Hoffman JC Reed 1994 Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo Oncogene 9 1799 1805
35. VL Bonfitto LA de Angelo Andrade 2003 p53, estrogen and progesterone receptors in diagnostic curettage for endometrial adenocarcinoma and their correlation with morphological data and disease stage at hysterectomy Sao Paulo Med J 121 163 166
36. MF Kohler A Berchuck AM Davidoff PA Humphrey RK Dodge JD Iglehart JT Soper DL Clarke-Pearson RC Bast Jr JR Marks 1992 Overexpression and mutation of p53 in endometrial carcinoma Cancer Res 52 1622 1627
37. NW Hamel TJ Sebo TO Wilson GL Keeney PC Roche VJ Suman TC Hu KC Podratz 1996 Prognostic value of p53 and proliferation cell nuclear antigen expression in endometrial carcinoma Gynecol Oncol 62 192 198
38. K Ito K Watanabe S Nasim H Sasano S Sato A Yajima SG Silverberg CT Garrett 1994 Prognostic significance of p53 overexpression in endometrial cancer Cancer Res 54 4667 4670
39. DR Derossi K Ito J Couto Filho CE Bacchi 2003 Avaliação da expressão da proteína bcl-2 no carcinoma de mama: estudo em punção aspirativa por agulha fina; correlação com grau histológico em espécimes cirúrgicos correspondentes J Bras Patol Med Lab 39 229 235