p53 Expression as a prognostic indicator of 5-year survival in endometrial cancer

Gynecologic Oncology

Volumn 74, Issue 3, 1999, Pages 468-471

  Geisler, John P ^a   Geisler, Hans E ^a   Wiemann, Michael C ^b   Zhou, Zhen ^c   Miller, Greg A ^c   Crabtree, William ^c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b St Vincent Hospitals and Health Services   (United States)

^c NONE   (United States)

Author keywords

Endometrial cancer; p53; Survival

Indexed keywords

PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CANCER; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

EID: 0032872152     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1006/gyno.1999.5482     Document Type: Article

References (15)

1. Landis SH, Murray T, Bolden S, Wingo PA: Cancer statistics, 1999. CA Cancer J Clin 49:8-31, 1999
2. Parkin DM, Pisani P, Ferlay J: Global cancer statistics. CA Cancer J Clin 49:33-64, 1999
3. Geisler JP, Zhou Z, Miller GA, Wiemann MC, Geisler HE: p53 as a prognostic indicator in endometrial cancer. Gynecol Oncol 61:245-248, 1996
4. Levine AJ: The role of p53 as a tumor suppressor gene in human cancers. Adv Oncol 8:3-9, 1993
5. Reinartz JJ, George E, Lindgren BR, Niehans GA: Expression of p53, transforming growth factor alpha, epidermal growth factor receptor, and c-erbB-2 in endometrial carcinoma and correlation with survival and known predictors of survival. Hum Pathol 25:1075-1083, 1994
6. Levine AJ, Perry ME, Chang A, Silver A, Dittmer D, Wu M, Welsh D: The 1993 Walter Hubert Lecture: The role of p53 tumor-suppressor gene in tumorigenesis. Br J Cancer 69:409-416, 1994
7. Azumi N, Czernobilsky B: Immunohistochemistry, in Kurman RJ, (ed): Blaustein's Pathology of the Female Genital Tract, fourth ed. New York, Springer-Verlag, 1994, pp 1131-1160
8. Baker VV: Genetics in Gynecologic Cancer, in Holzman GB, Rinehart RD, DiSaia PJ, (eds): Precis, Oncology: An Update in Obstetrics and Gynecology. American College of Obstetricians and Gynecologists, Washington, D.C., 1998, Vol 5, pp 2-7
9. Ioffe OB, Papadinitriou JC, Drachenberg CB: Correlation of proliferation indices, apoptosis, and related oncogene expression (bcl-2 and c-erb-2) and p53 in proliferative, hyperplastic, and malignant endometrium. Hum Pathol 29:1150-1159, 1998
10. Lukes AS, Kohler MF, Pieper CF, Kerns BJ, Bentley R, Rodriguez GC, Soper JT, Clarke-Pearson DL, Bast RC Jr, Berchuck A: Multivariate analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer. Cancer 73:2380-2385, 1994
11. Kohler MF, Berchuck A, Davidoff AM, Humphrey PA, Dodge RK, Iglehart JD, Soper JT, Clarke-Pearson DL, Bast RC Jr, Marks JR: Over-expression and mutation of p53 in endometrial carcinoma. Cancer Res 52:1622-1627, 1992
12. Kohler MF, Carney P, Dodge R, Soper JT, Clarke-Pearson DL, Marks JR, Berchuck A: p53 overexpression in advanced-stage endometrial carcinoma. Am J Obstet Gynecol 175:1246-1252, 1996
13. Soong R, Robbins PD, Dix BR, Grieu F, Lim B, Knowles S, Williams KE, Turbett GR, House AK, Iacopetta BJ: Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas. Hum Pathol 27:1050-1055, 1996
14. Coppola D, Fu L, Nicosia SV, Kounelis S, Jones M: Prognostic significance of p53, bcl-2, vimentin, and S100 protein-positive langerhans cells in endometrial carcinoma. Hum Pathol 29:455-462, 1998
15. Reinartz JJ, George E, Lindgren BR, Niehans GA: Expression of p53, transforming growth factor alpha, epidermal growth factor receptor, and c-erbB-2 in endometrial carcinoma and correlation with survival and known predictors of survival. Hum Pathol 25:1075-1083, 1994