Caffeine dependence in rats: Effects of exposure duration and concentration

Physiology and Behavior

Volumn 95, Issue 1-2, 2008, Pages 252-257

  Dingle, Rachel N ^a   Dreumont Boudreau, Sarah E ^a   LoLordo, Vincent M ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Associative learning; Caffeine; Conditioned avoidance; Dependence; Dose; Rats; Withdrawal

Indexed keywords

CAFFEINE; WATER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; FLAVOR; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATE DEPENDENT LEARNING; TASTE AVERSION;

EID: 49349098170     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2008.06.007     Document Type: Article

References (21)

1. Griffiths R.R., and Chausmer A.L. Caffeine as a model drug of dependence: recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome, and caffeine negative reinforcement. Nihon Shinkei Seishin Yakurigaku Zasshi 20 5 (2000) 223-231
2. Daly J.W., Holmen J., and Fredholm B.B. [Is caffeine addictive? The most widely used psychoactive substance in the world affects same parts of the brain as cocaine]. Lakartidningen 95 51-52 (1998) 5878-5883
3. Nehlig A. Are we dependent upon coffee and caffeine? A review on human and animal data. Neurosci Biobehav Rev 23 4 (1999) 563-576
4. Holtzman S.G. Complete, reversible, drug-specific tolerance to stimulation of locomotor activity by caffeine. Life Sci 33 8 (1983) 779-787
5. Finn I.B., and Holtzman S.G. Tolerance to caffeine-induced stimulation of locomotor activity in rats. J Pharmacol Exp Ther 238 2 (1986) 542-546
6. Mumford G.K., Neill D.B., and Holtzman S.G. Caffeine elevates reinforcement threshold for electrical brain stimulation: tolerance and withdrawal changes. Brain Res 459 1 (1988) 163-167
7. Bhattacharya S.K., Satyan K.S., and Chakrabarti A. Anxiogenic action of caffeine: an experimental study in rats. J Psychopharmacol 11 3 (1997) 219-224
8. Revusky S., and Garcia J. Learned associations over long delays. In: B.G., and S.J. (Eds). Psychology of learning and motivation: advances in research and theory vol. 4 (1970), Academic Press, New York 1-84
9. Rusiniak K.W., Palmerino C.C., Rice A.G., Forthman D.L., and Garcia J. Flavor-illness aversions: potentiation of odor by taste with toxin but not shock in rats. J Comp Physiol Psychol 96 4 (1982) 527-539
10. Garcia J., Ervin F.R., and Koelling R.A. Toxicity of serum from irradiated donors. Nature 213 5077 (1967) 682-683
11. Bernstein I.L. Taste aversion learning: a contemporary perspective. Nutrition 15 3 (1999) 229-234
12. Welzl H., D'Adamo P., and Lipp H.P. Conditioned taste aversion as a learning and memory paradigm. Behav Brain Res 125 1-2 (2001) 205-213
13. Riley A.L., and Freeman K.B. Conditioned taste aversion: a database. Pharmacol Biochem Behav 77 3 (2004) 655-656
14. Parker L., Failor A., and Weidman K. Conditioned preferences in the rat with an unnatural need state: morphine withdrawal. J Comp Physiol Psychol 82 2 (1973) 294-300
15. Gauvin D.V., Briscoe R.J., Baird T.J., Vallett M., and Holloway F.A. The paradoxical hedonic valence of acute ethanol withdrawal (hangover) states in rats: place and taste conditioning. Alcohol 14 3 (1997) 261-268
16. Mucha R.F. Preferences for tastes paired with a nicotine antagonist in rats chronically treated with nicotine. Pharmacol Biochem Behav 56 2 (1997) 175-179
17. Freeman K.B., and Riley A.L. Cocaine-induced conditioned taste avoidance over extended conditioned stimulus-unconditioned stimulus intervals. Behav Pharmacol 16 7 (2005) 591-595
18. Vitiello M.V., and Woods S.C. Evidence for withdrawal from caffeine by rats. Pharmacol Biochem Behav 6 5 (1977) 553-555
19. Dreumont-Boudreau S.E., Dingle R.N., Alcolado G.M., and LoLordo V.M. Conditioned flavour avoidance as a measure of withdrawal in rats chronically exposed to a caffeine solution. Physiol Behav 95 (2008) 245-251 10.1016/j.physbeh.2008.06.008
20. Sclafani A., and Nissenbaum J.W. Robust conditioned flavor preference produced by intragastric starch infusions in rats. Am J Physiol 255 4 Pt 2 (1988) R672-675
21. Domjan M. Selective suppression of drinking during a limited period following aversive drug treatment in rats. J Exp Psychol Anim Behav Processes 3 1 (1977) 66-76