Pharmacological Effects of Nicotine on Norepinephrine Metabolism in Rat Brown Adipose Tissue: Relevance to Nicotinic Therapies for Smoking Cessation

Toxicologic Pathology

Volumn 36, Issue 4, 2008, Pages 568-575

  Brees, Dominique J ^a   Elwell, Michael R ^a   Tingley, F David ^a   Sands, Steven B ^a   Jakowski, Amy B ^a   Shen, Amy C ^a   Cai, Jenny Hon ^a   Finkelstein, Martin B ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

brown adipose tissue; hibernoma; nAChR; nicotine; norepinephrine; rats; varenicline

Indexed keywords

MESSENGER RNA; NICOTINE; NORADRENALIN; UNCOUPLING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CARCINOGENESIS; CATECHOLAMINE METABOLISM; CELL VACUOLE; CONTROLLED STUDY; DRUG CARCINOGENICITY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; FEMALE; HIBERNOMA; LOW DRUG DOSE; MALE; MEDIASTINUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCAPULA; SEX DIFFERENCE; SMOKING CESSATION; SPRAGUE DAWLEY RAT; TUMOR LOCALIZATION;

ADIPOSE TISSUE, BROWN; ANIMALS; BENZAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LIPOMA; MALE; MEDIASTINAL NEOPLASMS; NICOTINE; NICOTINIC AGONISTS; NOREPINEPHRINE; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; SMOKING CESSATION;

RATTUS;

EID: 49349093443     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/0192623308317424     Document Type: Article

References (25)

1. Arai K Kim K Kaneko K Iketani M Otagiri A Yamauchi N Shibasaki T Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats Am J Physiol Endocrinol Metab 2001 280 E867 76
2. Arch JR Ainsworth AT Cawthorne MA Piercy V Sennitt MV Thody VE Wilson C Wilson S Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs Nature 1984 309 163 65
3. Bukowiecki L Collet AJ Follea N Guay G Jahjah L Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to cold and hyperphagia Am J Physiol 1982 242 E353 59
4. Cannon B Nedergaard J Brown adipose tissue: function and physiological significance Physiol Rev 2004 84 277 359
5. Chaudhry A Granneman JG Differential regulation of functional responses by beta-adrenergic receptor subtypes in brown adipocytes Am J Physiol 1999 277 R147 53
6. Coe JW Brooks PR Vetelino MG Wirtz MC Arnold EP Huang J Sands SB Davis TI Lebel LA Fox CB Shrikhande A Heym JH Schaeffer E Rollema H Lu Y Mansbach RS Chambers LK Rovetti CC Schulz DW Tingley FD III O’Neill BT Varenicline: an α4β2 nicotinic receptor partial agonist for smoking cessation J Med Chem 2005 48 3474 77
7. Coleman GL Four intrathoracic hibernomas in rats Vet Pathol 1980 17 634 37
8. Echtay KS Roussel D St-Pierre J Jekabsons MB Cadenas S Stuart JA Harper JA Roebuck SJ Morrison A Pickering S Clapham JC Brand MD Superoxide activates mitochondrial uncoupling proteins Nature 2002 415 96 99
9. Furlong MA Fanburg-Smith JC Miettinen M The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases Am J Surg Pathol 2001 25 809 14
10. Giordano A Frontini A Castellucci M Cinti S Presence and distribution of cholinergic nerves in rat mediastinal brown adipose tissue J Histochem Cytochem 2004 52 923 30
11. Himms-Hagen J Brown adipose tissue metabolism and thermogenesis Annu Rev Nutr 1985 5 69 94
12. Lean ME James WP Trayhurn P Nicholls DG Brown adipose tissue in man Brown Adipose Tissue 1986 Baltimore, MD E. Arnold 339 65
13. Lindquist JM Fredriksson JM Rehnmark S Cannon B Nedergaard J Beta 3- and alpha1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in Brown adipocytes J Biol Chem 2000 275 22670 77
14. Lupien JR Bray GA Nicotine increases thermogenesis in brown adipose tissue in rats Pharmacol Biochem Behav 1988 29 33 37
15. Malo A Puerta M Oestradiol and progesterone change beta3-adrenergic receptor affinity and density in brown adipocytes Eur J Endocrinol 2001 145 87 91
16. Nagase I Sasaki N Tsukazaki K Yoshida T Morimatsu M Saito M Hyperplasia of brown adipose tissue after chronic stimulation of beta 3-adrenergic receptor in rats Jpn J Vet Res 1994 42 137 45
17. Nedergaard J Golozoubova V Matthias A Asadi A Jacobsson A Cannon B UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency Biochim Biophys Acta 2001 1504 82 106
18. Poulet FM Berardi MR Halliwell W Hartman B Auletta C Bolte H Development of hibernomas in rats dosed with phentolamine mesylate during the 24-month carcinogenicity study Toxicol Pathol 2004 32 558 66
19. Pruimboom-Brees IM Brees DJ Shen AC Keener M Francone O Amacher DE Loy JK Kerlin RL Using laser scanning cytometry to measure PPAR-mediated peroxisome proliferation and beta oxidation Toxicol Pathol 2005 33 86 91
20. Rezvani AH Levin ED Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperature Int J Dev Neurosci 2004 22 349 54
21. Rodriguez E Monjo M Rodriguez-Cuenca S Pujol E Amengual B Roca P Palou A Sexual dimorphism in the adrenergic control of rat brown adipose tissue response to overfeeding Pflugers Arch 2001 442 396 403
22. Rollema H Chambers LK Coe JW Glowa J Hurst RS Lebel LA Lu Y Mansbach RS Mather RJ Rovetti CC Sands SB Schaeffer E Schulz DW Tingley FD III Williams KE Pharmacological profile of the α4β2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid Neuropharmacology 2007 52 985 94
23. Sell H Deshaies Y Richard D The brown adipocyte: update on its metabolic role Int J Biochem Cell Biol 2004 36 2098 104
24. Stefanski SA Elwell MR Yoshitomi K Malignant hibernoma in a Fischer 344 rat Lab Anim Sci 1987 37 347 50
25. Tsukazaki K Nikami H Shimizu Y Kawada T Yoshida T Saito M Chronic administration of beta-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue J Biochem (Tokyo) 1995 117 96 100