The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation

Molecular and Cellular Biology

Volumn 28, Issue 17, 2008, Pages 5312-5327

  Dey, Bijan K ^a   Stalker, Leanne ^a   Schnerch, Angelique ^a   Bhatia, Mickie ^a   Taylor Papidimitriou, Joyce ^b   Wynder, Christopher ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; EARLY GROWTH RESPONSE FACTOR 1; HISTONE DEMETHYLASE LYSINE DEMETHYLASE 5B; HISTONE H3; METHYLTRANSFERASE; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; DEMETHYLATION; EMBRYONIC STEM CELL; MITOSIS RATE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CELL PROLIFERATION; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; HISTONES; HOMEODOMAIN PROTEINS; LYSINE; MICE; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; NEURONS; OXIDOREDUCTASES, N-DEMETHYLATING; REPRESSOR PROTEINS; TCF TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 49349092791     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00128-08     Document Type: Article

References (49)

1. Abdulkader, I., L. Sanchez, J. Cameselle-Teijeiro, F. Gude, J. E. Chavez, R. Lopez-Lopez, J. Forteza, and M. Fraga. 2005. Cell-cycle- associated markers and clinical outcome in human epithelial cancers: a tissue microarray study. Oncol. Rep. 14:1527-1531.
2. Affolter, M., and K. Basler. 2007. The decapentaplegic morphogen gradient: from pattern formation to growth regulation. Nat. Rev. Genet. 8:663-674.
3. Benevolenskaya, E. V., H. L. Murray, P. Branton, R. A. Young, and W. G. Kaelin, Jr. 2005. Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. Mol. Cell 18:623-635.
4. Bernstein, B. E., T. S. Mikkelsen, X. Xie, M. Kamal, D. J. Huebert, J. Cuff, B. Fry, A. Meissner, M. Wernig, K. Plath, R. Jaenisch, A. Wagschal, R. Feil, S. L. Schreiber, and E. S. Lander. 2006. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125:315-326.
5. Besson, A., H. C. Hwang, S. Cicero, S. L. Donovan, M. Gurian-West, D. Johnson, B. E. Clurman, M. A. Dyer, and J. M. Roberts. 2007. Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev. 21:1731-1746.
6. Boyer, L. A., K. Plath, J. Zeitlinger, T. Brambrink, L. A. Medeiros, T. I. Lee, S. S. Levine, M. Wernig, A. Tajonar, M. K. Ray, G. W. Bell, A. P. Otte, M. Vidal, D. K. Gilford, R. A. Young, and R. Jaenisch. 2006. Polycomb complexes repress developmental regulator in murine embryonic stem cells. Nature 441:349-353.
7. Carruthers, S., J. Mason, and N. Papalopulu. 2003. Depletion of the cell-cycle inhibitor p27(Xic1) impairs neuronal differentiation and increases the number of ElrC(+) progenitor cells in Xenopus tropicalis. Mech. Dev. 120:607-616.
8. Chambers, I., J. Silva, D. Colby, J. Nichols, B. Nijmeijer, M. Robertson, J. Vrana, K. Jones, L. Grotewold, and A. Smith. 2007. Nanog safeguards pluripotency and mediates germline development. Nature 450:1230-1234.
9. Christensen, J., K. Agger, P. A. Cloos, D. Pasini, S. Rose, L. Sennels, J. Rappsilber, K. H. Hansen, A. E. Salcini, and K. Helin. 2007. RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell 128:1063-1076.
10. Doble, B. W., S. Patel, G. A. Wood, L. K. Kockeritz, and J. R. Woodgett. 2007. Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev. Cell 12:957-971.
11. Ernst, P., J. K. Fisher, W. Avery, S. Wade, D. Foy, and S. J. Korsmeyer. 2004. Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev. Cell 6:437-443.
12. Frankenberg, S., L. Smith, A. Greenfield, and M. Zernicka-Goetz. 2007. Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation. BMC Dev. Biol. 7:8.
13. Grimmler, M., Y. Wang, T. Mund, Z. Cilensek, E. M. Keidel, M. B. Waddell, H. Jakel, M. Kallmann, R. W. Kriwacki, and L. Hengst. 2007. Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell 128:269-280.
14. Guenther, M. G., S. S. Levine, L. A. Boyer, R. Jaenisch, and R. A. Young. 2007. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130:77-88.
15. Guo, Y., R. Costa, H. Ramsey, T. Starnes, G. Vance, K. Robertson, M. Kelley, R. Reinbold, H. Scholer, and R. Hromas. 2002. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. Proc. Natl. Acad. Sci. USA 99:3663-3667.
16. Gutierrez, G. M., E. Kong, and P. W. Hinds. 2005. Master or slave: the complex relationship of RBP2 and pRb. Cancer Cell 7:501-502.
17. Hart, A. H., L. Hartley, M. Ibrahim, and L. Robb. 2004. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Dev. Dyn. 230:187-198.
18. Iwase, S., F. Lan, P. Bayliss, L. de la Torre-Ubieta, M. Huarte, H. H. Qi, J. R. Whetstine, A. Bonni, T. M. Roberts, and Y. Shi. 2007. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell 128:1077-1088.
19. Jenuwein, T., and C. D. Allis. 2001. Translating the histone code. Science 293:1074-1080.
20. Jorgensen, H. F., S. Giadrossi, M. Casanova, M. Endoh, H. Koseki, N. Brockdorff, and A. G. Fisher. 2006. Stem cells primed for action: polycomb repressive complexes restrain the expression of lineage-specific regulators in embryonic stem cells. Cell Cycle 5:1411-1414.
21. Kanda, S., Y. Tamada, A. Yoshidome, I. Hayashi, and T. Nishiyama. 2004. Over-expression of bHLH genes facilitate neural formation of mouse embryonic stem (ES) cells in vitro. Int. J. Dev. Neurosci. 22:149-156.
22. Krishnaraju, K., B. Hoffman, and D. A. Liebermann. 2001. Early growth response gene 1 stimulates development of hematopoietic progenitor cells along the macrophage lineage at the expense of the granulocyte and erythroid lineages. Blood 97:1298-1305.
23. Krivtsov, A. V., and S. A. Armstrong. 2007. MLL translocations, histone modifications and leukaemia stem-cell development. Nat. Rev. Cancer 7:823-833.
24. Lanoix, J., A. Mullick, Y. He, R. Bravo, and D. Skup. 1998. Wild-type egr1/Krox24 promotes and dominant-negative mutants inhibit, pluripotent differentiation of p19 embryonal carcinoma cells. Oncogene 17:2495-2504.
25. Lee, M. G., J. Norman, A. Shilatifard, and R. Shiekhattar. 2007. Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell 128:877-887.
26. Leivonen, M., S. Nordling, J. Lundin, K. von Boguslawski, and C. Haglund. 2001. p27 expression correlates with short-term, but not with long-term prognosis in breast cancer. Breast Cancer Res. Treat. 67:15-22.
27. Loyer, P., S. Cariou, D. Glaise, M. Bilodeau, G. Baffet, and C. Guguen-Guillouzo. 1996. Growth factor dependence of progression through G1 and S phases of adult rat hepatocytes in vitro. Evidence of a mitogen restriction point in mid-late G1. J. Biol. Chem. 271:11484-11492.
28. Lu, P. J., K. Sundquist, D. Baeckstrom, R. Poulsom, A. Hanby, S. Meier-Ewert, T. Jones, M. Mitchell, P. Pitha-Rowe, P. Freemont, and J. Taylor-Papadimitriou. 1999. A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J. Biol. Chem. 274:15633-15645.
29. Madsen, B., B. Spencer-Dene, R. Poulsom, D. Hall, P. J. Lu, K. Scott, A. T. Shaw, J. M. Burchell, P. Freemont, and J. Taylor-Papadimitriou. 2002. Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. Gene Expr. Patterns 2:275-282.
30. Mikkelsen, T. S., M. Ku, D. B. Jaffe, B. Issac, E. Lieberman, G. Giannoukos, P. Alvarez, W. Brockman, T. K. Kim, R. P. Koche, W. Lee, E. Mendenhall, A. O'Donovan, A. Presser, C. Russ, X. Xie, A. Meissner, M. Wernig, R. Jaenisch, C. Nusbaum, E. S. Lander, and B. E. Bernstein. 2007. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448:553-560.
31. Molofsky, A. V., R. Pardal, T. Iwashita, I. K. Park, M. F. Clarke, and S. J. Morrison. 2003. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425:962-967.
32. Moser, M., and G. Campbell. 2005. Generating and interpreting the Brinker gradient in the Drosophila wing. Dev. Biol. 286:647-658.
33. Nguyen, L., A. Besson, J. I. Heng, C. Schuurmans, L. Teboul, C. Parras, A. Philpott, J. M. Roberts, and F. Guillemot. 2006. p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev. 20:1511-1524.
34. Niwa, H., J. Miyazaki, and A. G. Smith. 2000. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24:372-376.
35. Nowak, K., K. Kerl, D. Fehr, C. Kramps, C. Gessner, K. Killmer, B. Samans, B. Berwanger, H. Christiansen, and W. Lutz. 2006. BMU is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas. Nucleic Acids Res. 34:1745-1754.
36. Park, I. K., S. J. Morrison, and M. F. Clarke. 2004. Bmi1, stem cells, and senescence regulation. J. Clin. Investig. 113:175-179.
37. Park, I. K., D. Qian, M. Kiel, M. W. Becker, M. Pihalja, I. L. Weissman, S. J. Morrison, and M. F. Clarke. 2003. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423:302-305.
38. Pereira, L., F. Yi, and B. J. Merrill. 2006. Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Mol. Cell. Biol. 26:7479-7491.
39. Shi, Y., F. Lan, C. Matson, P. Mulligan, J. R. Whetstine, P. A. Cole, R. A. Casero, and Y. Shi. 2004. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119:941-953.
40. Shilatifard, A. 2006. Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu. Rev. Biochem. 75:243-269.
41. Sims, R. J., III, K. Nishioka, and D. Reinberg. 2003. Histone lysine methylation: a signature for chromatin function. Trends Genet. 19:629-639.
42. Strahl, B. D., and C. D. Allis. 2000. The language of covalent histone modifications. Nature 403:41-45.
43. Szutorisz, H., C. Canzonetta, A. Georgiou, C. M. Chow, L. Tora, and N. Dillon. 2005. Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage. Mol. Cell. Biol. 25:1804-1820.
44. Tan, K., A. L. Shaw, B. Madsen, K. Jensen, J. Taylor-Papadimitriou, and P. S. Freemont. 2003. Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. J. Biol. Chem. 278:20507-20513.
45. van der Lugt, N. M., M. Alkema, A. Berns, and J. Deschamps. 1996. The polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. Mech. Dev. 58:153-164.
46. Waters, C. M., D. C. Hancock, and G. I. Evan. 1990. Identification and characterisation of the egr-1 gene product as an inducible, short-lived, nuclear phosphoprotein. Oncogene 5:669-674.
47. Xiang, Y., Z. Zhu, G. Han, X. Ye, B. Xu, Z. Peng, Y. Ma, Y. Yu, H. Lin, A. P. Chen, and C. D. Chen. 2007. JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc. Natl. Acad. Sci. USA 104:19226-19231,
48. Yamane, K., K. Tateishi, R. J. Klose, J. Fang, L. A. Fabrizio, H. Erdjument-Bromage, J. Taylor-Papadimitriou, P. Tempst, and Y. Zhang. 2007. PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol. Cell 25:801-812.
49. Yu, J., V. Baron, D. Mercola, T. Mustelin, and E. D. Adamson. 2007. A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells. Cell Death Differ. 14:436-446.