The surgical pathology of notochordal remnants in adult intervertebral disks: A report of 3 cases

American Journal of Surgical Pathology

Volumn 32, Issue 8, 2008, Pages 1123-1129

  Wang, Wei Lien ^a   Abramson, Jerome H ^b   Ganguly, Aniruddha ^a   Rosenberg, Andrew E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Erlanger Medical Center   (United States)

Author keywords

Adult intervertebral disk; Benign notochordal cell tumor; Chordoma; Notochordal remnant

Indexed keywords

CYTOKERATIN 18;

ADULT; ARTICLE; BENIGN NOTOCHORDAL CELL TUMOR; CASE REPORT; CHORDOMA; CLINICAL FEATURE; EOSINOPHIL; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; MALE; DIFFERENTIAL DIAGNOSIS; MIDDLE AGED; NOTOCHORD; PATHOLOGY; SPINAL CORD TUMOR; SPINE DISEASE;

ADULT; CHORDOMA; DIAGNOSIS, DIFFERENTIAL; HUMANS; INTERVERTEBRAL DISK; MALE; MIDDLE AGED; NOTOCHORD; SPINAL DISEASES; SPINAL NEOPLASMS;

EID: 49249137399     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181757954     Document Type: Article

References (35)

1. Beadle O. Intervertebral Discs; Observations on Their Normal and Morbid Anatomy in Relation to Certain Spinal Deformities. London: H.M. Stationary Office; 1931.
2. Chauvel A, Taillat F, Gille O, et al. Giant vertebral notochordal rest: a new entity distinct from chordoma. Histopathology. 2005;47:643-652.
3. Condon CC. Benign and malignant chordomas: a clinico-anatomi-cal study of twenty-two cases. Am J Pathol. 1952;28:793-821.
4. Conventry MB, Ghormley RK, Kernohan JW. The intervertebral disc: its microscopic anatomy and pathology. J Bone Joint Surg. 1945;28:233-247.
5. Eckert C, Decker A. Pathological studies of intervertebral discs. J Bone Joint Surg. 1947;29:447-454.
6. Fick R. Handbuch der Anatomie und Mechanik der Gelenke. Part I. Anatomie der Gelenke. Jena: G. Fisher; 1904:66-69.
7. Fleming A, Keynes RJ, Tannahill D. The role of the notochord in vertebral column formation. J Anat. 2001;199:177-180.
8. Gotz W, Kasper M, Fischer G, et al. Intermediate filament typing of the human embryonic and fetal notochord. Cell Tissue Res. 1995;280:455-462.
9. Horwitz T. Chordal ectopia and its possible relation to chordoma. Arch Pathol. 1941;31:354-362.
10. Horwitz T. The human notochord. A Study of its Development and Regression, Variations and Pathologic Derivative, Chordoma. Indianapolis, IN: Indiana University School of Medicine; 1977.
11. Hunter CJ, Matyas JR, Duncan NA. The notochordal cell in the nucleus pulposus: a review in the context of tissue engineering. Tissue Eng. 2003;9:667-677.
12. Hunter CJ, Matyas JR, Duncan NA. Cytomorphology of noto-chordal and chondrocytic cells from the nucleus pulposus: a species comparison. J Anat. 2004;205:357-362.
13. Keyes DC, Compere EL. The normal and pathological physiology of the nucleus pulposus of the intervertebral disk. J Bone Joint Surg. 1932;14:897-938.
14. Kyriakos M, Totty WG, Lenke LG. Giant vertebral notochordal rest. A lesion distinct from chordoma: discussion of an evolving concept. Am J Surg Pathol. 2003;27:396-406.
15. Lasser AB, Munsterberg AE. The role of positive and negative signals in somite patterning. Curr Opin Neurobiol. 1996;6:57-63.
16. Mehnert F, Beschorner R, Kuker W, et al. Retroclival ecchordosis physaliphora: MR imaging and review of literature. Am J Neuroradiol. 2004;25:1851-1855.
17. Mirra JM, Brien EW. Giant notochordal hamartoma of intraoss-eous origin: a newly reported benign entity to be distinguished from chordoma. Report of two cases. Skelet Radiol. 2001;30:698-709.
18. Musgrove J. Persistence of the notochord in the human subject. J Anat. 1891;5:386-389.
19. Naka T, Iwamoto Y, Shinohara N, et al. Cyokeratin subtyping in chordomas and the fetal notochord: an immunohisto-chemical analysis of aberrant expression. Mod Pathol. 1997;10: 545-551.
20. Pazzaglia UE, Salisbury JR, Byers PD. Development and involution of the notochord in the human spine. J R Soc Med. 1989;82: 413-415.
21. Peacock A. Observations on the postnatal structure of the intervertebral disk in man. J Anat. 1952;86:162-179.
22. Pytel P, Wollmann RL, Fessler RG, et al. Degenerative spine disease: pathologic findings in 985 surgical specimens. Am J Clin Pathol. 2006;125:193-202.
23. Roberts S, Evans H, Trivedi J, et al. Histology and pathology of the human intervertebral disc. J Bone Joint Surg. 2006;88(suppl 1):10.
24. Schaffer J. In von Möllendörff's Handbuch der Mikroskopischen Anatomie des Menschen. Berlin: Springer; 1930:31-44.
25. Schmorl G, Junghanns H. The Human Spine in Health and Disease. New York, London: Grune & Stratton; 1971.
26. Schwabe R. Untersuchungen über die Rückbildung der Bandscheiben im menschlichen Kreuzbein. Virchow Arch. 1932;287: 651-713.
27. Smits P, Lefebvre V. So×5 and So×6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Development. 2003;130:1135-1148.
28. Stemple DL. Structure and function of the notochord: an essential organ for chordate development. Development. 2005;132:2503-2512.
29. Taylor J. Persistence of the notochordal canal in vertebrae. J Anat. 1972;111:211-217.
30. Trout JJ, Buckwalter JA, Moore KC. Ultrastructure of the human intervertebral disc: II. Cells of the nucleus pulposus. Anat Rec. 1982;204:307-314.
31. Trout JJ, Buckwalter JA, Moore KC, et al. Ultrastructure of the human intervertebral disc. I. Changes in notochordal cells with age. Tissue Cell. 1982;14:359-369.
32. Walmsley R. The development and growth of the intervertebral disk. Edinburgh Med J. 1953;60:341-363.
33. Yamaguchi T, Suzuki S, Ishiiwa H, et al. Benign notochordal cell tumors: a comparative histological study of benign notochordal cell tumors, classic chordomas, and notochordal vestiges of fetal intervertebral discs. Am J Surg Pathol. 2004;28:756-761.
34. Yamaguchi T, Suzuki S, Ishiiwa H, et al. Intraosseous benign notochordal cell tumours: overlooked precursors of classic chordomas? Histopathology. 2004;44:597-602.
35. Yamaguchi T, Watanabe-Ishiiwa H, Suzuki S, et al. Incipient chordoma: a report of two cases of early-stage chordoma arising from benign notochordal cell tumors. Mod Pathol. 2005;18: 1005-1010.