Automated patch-clamp technique: Increased throughput in functional characterization and in pharmacological screening of small-conductance Ca 2+ release-activated Ca2+ channels

Journal of Biomolecular Screening

Volumn 13, Issue 7, 2008, Pages 638-647

  Schrøder, Rikke L ^a   Friis, Søren ^a   Sunesen, Morten ^a   Mathes, Chris ^a,b   Willumsen, Niels J ^c  

^a Sophion Bioscience A/S   (Denmark)

^b Sophion Bioscience Inc   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Automated patch clamp; CRAC channels; Intracellular calcium stores; QPatch

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; 2 AMINOETHOXYDIPHENYLBORANE; CALCIUM CHANNEL STIMULATING AGENT; CALCIUM ION; CELL MEMBRANE PROTEIN; EGTAZIC ACID; IONOMYCIN; SMALL CONDUCTANCE CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL; THAPSIGARGIN; VOLTAGE GATED CALCIUM CHANNEL;

ACCURACY; ANIMAL CELL; ARTICLE; AUTOMATION; CALCIUM CELL LEVEL; CELL MEMBRANE RESISTANCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; LEUKEMIA CELL; MAST CELL LEUKEMIA; NONHUMAN; PATCH CLAMP; PHARMACOLOGICAL BLOCKING; PHARMACOLOGICAL PROCEDURES; PRIORITY JOURNAL; RAT; SIGNAL NOISE RATIO; WHOLE CELL;

ANIMALS; AUTOMATION; CALCIUM; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; ELECTROPHYSIOLOGY; IMIDAZOLES; INHIBITORY CONCENTRATION 50; INOSITOL 1,4,5-TRISPHOSPHATE; IONOMYCIN; PATCH-CLAMP TECHNIQUES; PLATELET AGGREGATION INHIBITORS; RATS; THAPSIGARGIN;

EID: 49249134845     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057108320274     Document Type: Article

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