메뉴 건너뛰기




Volumn 7, Issue 9, 2008, Pages 601-609

Tyrosine Kinase Inhibitors in Clinical Practice: Patient Selection

Author keywords

Renal cell carcinoma; Sunitinib; Treatment algorithm; Tyrosine kinase inhibitor

Indexed keywords

ALPHA INTERFERON; AXITINIB; BEVACIZUMAB; CYTOKINE; EVEROLIMUS; INTERLEUKIN 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PAZOPANIB; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; TEMSIROLIMUS;

EID: 49149110825     PISSN: 15699056     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eursup.2008.06.001     Document Type: Review
Times cited : (6)

References (42)
  • 1
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer R.J., Rini B.I., Bukowski R.M., et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 295 (2006) 2516-2524
    • (2006) JAMA , vol.295 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 2
    • 0032772880 scopus 로고    scopus 로고
    • Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
    • Motzer R.J., Mazumdar M., Bacik J., et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 17 (1999) 2530-2540
    • (1999) J Clin Oncol , vol.17 , pp. 2530-2540
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, J.3
  • 3
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • Motzer R.J., Bacik J., Murphy B.A., Russo P., and Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 20 (2002) 289-296
    • (2002) J Clin Oncol , vol.20 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3    Russo, P.4    Mazumdar, M.5
  • 4
    • 34548310217 scopus 로고    scopus 로고
    • Sunitinib versus interferon-alfa (IFNα) as first-line treatment of metastatic renal cell carcinoma (mRCC):updated results and analysis of prognostic factors
    • Motzer R.J., Figlin R.A., Hutson T.E., et al. Sunitinib versus interferon-alfa (IFNα) as first-line treatment of metastatic renal cell carcinoma (mRCC):updated results and analysis of prognostic factors. J Clin Oncol 25 (2007) 240S
    • (2007) J Clin Oncol , vol.25
    • Motzer, R.J.1    Figlin, R.A.2    Hutson, T.E.3
  • 5
    • 1442290393 scopus 로고    scopus 로고
    • Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma
    • Motzer R.J., Bacik J., Schwartz L.H., et al. Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J Clin Oncol 22 (2004) 454-463
    • (2004) J Clin Oncol , vol.22 , pp. 454-463
    • Motzer, R.J.1    Bacik, J.2    Schwartz, L.H.3
  • 6
    • 34547108341 scopus 로고    scopus 로고
    • Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy
    • Choueiri T.K., Garcia J.A., Elson P., et al. Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. Cancer 110 (2007) 543-550
    • (2007) Cancer , vol.110 , pp. 543-550
    • Choueiri, T.K.1    Garcia, J.A.2    Elson, P.3
  • 7
    • 41149156160 scopus 로고    scopus 로고
    • Sunitinib in metastatic renal cell carcinoma (mRCC): preliminary assessment of safety and efficacy in an expanded access trial with subpopulation analysis [abstract]
    • Gore M., Szczylik C., Porta C., et al. Sunitinib in metastatic renal cell carcinoma (mRCC): preliminary assessment of safety and efficacy in an expanded access trial with subpopulation analysis [abstract]. Eur J Cancer Suppl 5 (2007) 299
    • (2007) Eur J Cancer Suppl , vol.5 , pp. 299
    • Gore, M.1    Szczylik, C.2    Porta, C.3
  • 8
    • 49149091251 scopus 로고    scopus 로고
    • Sunitinib versus interferon (IFN)-alfa as first-line treatment of metastatic renal cell carcinoma (mRCC): updated efficacy and safety results and further analysis of prognostic factors [abstract]
    • Motzer R.J., Michaelson M.D., and Hutson T.E. Sunitinib versus interferon (IFN)-alfa as first-line treatment of metastatic renal cell carcinoma (mRCC): updated efficacy and safety results and further analysis of prognostic factors [abstract]. Eur J Cancer Suppl 5 (2007) 301
    • (2007) Eur J Cancer Suppl , vol.5 , pp. 301
    • Motzer, R.J.1    Michaelson, M.D.2    Hutson, T.E.3
  • 10
    • 0037407573 scopus 로고    scopus 로고
    • Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma
    • Cheville J.C., Lohse C.M., Zincke H., Weaver A.L., and Blute M.L. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol 27 (2003) 612-624
    • (2003) Am J Surg Pathol , vol.27 , pp. 612-624
    • Cheville, J.C.1    Lohse, C.M.2    Zincke, H.3    Weaver, A.L.4    Blute, M.L.5
  • 11
    • 24644496731 scopus 로고    scopus 로고
    • Histological subtyping and nuclear grading of renal cell carcinoma and their implications for survival: a retrospective nation-wide study of 629 patients
    • Gudbjartsson T., Hardarson S., Petursdottir V., Thoroddsen A., Magnusson J., and Einarsson G.V. Histological subtyping and nuclear grading of renal cell carcinoma and their implications for survival: a retrospective nation-wide study of 629 patients. Eur Urol 48 (2005) 593-600
    • (2005) Eur Urol , vol.48 , pp. 593-600
    • Gudbjartsson, T.1    Hardarson, S.2    Petursdottir, V.3    Thoroddsen, A.4    Magnusson, J.5    Einarsson, G.V.6
  • 12
    • 18844386435 scopus 로고    scopus 로고
    • Histologic predictors of renal cell carcinoma response to interleukin-2-based therapy
    • Upton M.P., Parker R.A., Youmans A., McDermott D.F., and Atkins M.B. Histologic predictors of renal cell carcinoma response to interleukin-2-based therapy. J Immunother 28 (2005) 488-495
    • (2005) J Immunother , vol.28 , pp. 488-495
    • Upton, M.P.1    Parker, R.A.2    Youmans, A.3    McDermott, D.F.4    Atkins, M.B.5
  • 13
    • 14144252047 scopus 로고    scopus 로고
    • Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma
    • Mekhail T.M., bou-Jawde R.M., Boumerhi G., et al. Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma. J Clin Oncol 23 (2005) 832-841
    • (2005) J Clin Oncol , vol.23 , pp. 832-841
    • Mekhail, T.M.1    bou-Jawde, R.M.2    Boumerhi, G.3
  • 14
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer R.J., Hutson T.E., Tomczak P., et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356 (2007) 115-124
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 15
    • 49149104495 scopus 로고    scopus 로고
    • Motzer RJ, Figlin R, Hutson TE, et al. Sunitinib versus interferon-alfa (IFNα) as first-line treatment of metastatic renal cell carcinoma (mRCC): updated results and analysis of prognostic factors. Oral presentation at: Annual Meeting of the American Society of Clinical Oncology; June 1-5, 2007; Chicago, IL, USA. Abstract 5024.
    • Motzer RJ, Figlin R, Hutson TE, et al. Sunitinib versus interferon-alfa (IFNα) as first-line treatment of metastatic renal cell carcinoma (mRCC): updated results and analysis of prognostic factors. Oral presentation at: Annual Meeting of the American Society of Clinical Oncology; June 1-5, 2007; Chicago, IL, USA. Abstract 5024.
  • 16
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer R.J., Michaelson M.D., Redman B.G., et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24 (2006) 16-24
    • (2006) J Clin Oncol , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 17
    • 49149101888 scopus 로고    scopus 로고
    • Sunitinib in patients with cytokine-refractory metastatic renal cell carcinoma (mRCC) [abstract]
    • George D.J., Michaelson M.D., Rosenberg J.E., et al. Sunitinib in patients with cytokine-refractory metastatic renal cell carcinoma (mRCC) [abstract]. Eur J Cancer Suppl 5 (2007) 303
    • (2007) Eur J Cancer Suppl , vol.5 , pp. 303
    • George, D.J.1    Michaelson, M.D.2    Rosenberg, J.E.3
  • 18
    • 49149121440 scopus 로고    scopus 로고
    • Sunitinib in advanced renal cell carcinoma: clinical evidence
    • Bellmunt J. Sunitinib in advanced renal cell carcinoma: clinical evidence. Eur Urol Suppl 7 (2008) 585-592
    • (2008) Eur Urol Suppl , vol.7 , pp. 585-592
    • Bellmunt, J.1
  • 19
    • 34247390131 scopus 로고    scopus 로고
    • Renal cell carcinoma guideline
    • Ljungberg B., Hanbury D., and Kuczyk M. Renal cell carcinoma guideline. Eur Urol 51 (2007) 1502-1510
    • (2007) Eur Urol , vol.51 , pp. 1502-1510
    • Ljungberg, B.1    Hanbury, D.2    Kuczyk, M.3
  • 20
    • 49149113229 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: kidney cancer v.1.2008. Available at: http://www.nccn.org/professionals/physician_gls/PDF/kidney.pdf.
    • National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: kidney cancer v.1.2008. Available at: http://www.nccn.org/professionals/physician_gls/PDF/kidney.pdf.
  • 21
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
    • Escudier B., Pluzanska A., Koralewski P., et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 370 (2007) 2103-2111
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 22
    • 49149124189 scopus 로고    scopus 로고
    • Rini BI, Halabi S, Rosenberg JE, et al. CALGB 90206: a phase III trial of bevacizumab plus interferon-alfa versus interferon-alfa monotherapy in metastatic renal cell carcinoma. Oral presentation at: 2008 Genitourinary Cancers Symposium of the American Society of Clinical Oncology; February 14-16, 2008; San Francisco, CA, USA. Abstract 350.
    • Rini BI, Halabi S, Rosenberg JE, et al. CALGB 90206: a phase III trial of bevacizumab plus interferon-alfa versus interferon-alfa monotherapy in metastatic renal cell carcinoma. Oral presentation at: 2008 Genitourinary Cancers Symposium of the American Society of Clinical Oncology; February 14-16, 2008; San Francisco, CA, USA. Abstract 350.
  • 23
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G., Carducci M., Tomczak P., et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 356 (2007) 2271-2281
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 24
    • 34547636060 scopus 로고    scopus 로고
    • Correlation of survival with tumor histology, age, and prognostic risk group for previously untreated patients with advanced renal cell carcinoma (adv RCC) receiving temsirolimus (TEMSR) or interferon-alpha (IFN) [abstract]
    • Dutcher J.P., Szczylik C., Tannir N., et al. Correlation of survival with tumor histology, age, and prognostic risk group for previously untreated patients with advanced renal cell carcinoma (adv RCC) receiving temsirolimus (TEMSR) or interferon-alpha (IFN) [abstract]. J Clin Oncol 25 Suppl (2007) 5033
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL , pp. 5033
    • Dutcher, J.P.1    Szczylik, C.2    Tannir, N.3
  • 25
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
    • Fyfe G., Fisher R.I., Rosenberg S.A., et al. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol 13 (1995) 688-696
    • (1995) J Clin Oncol , vol.13 , pp. 688-696
    • Fyfe, G.1    Fisher, R.I.2    Rosenberg, S.A.3
  • 26
    • 16644401873 scopus 로고    scopus 로고
    • Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma
    • McDermott D.F., Regan M.M., Clark J.I., et al. Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol 23 (2005) 133-141
    • (2005) J Clin Oncol , vol.23 , pp. 133-141
    • McDermott, D.F.1    Regan, M.M.2    Clark, J.I.3
  • 27
    • 0042914703 scopus 로고    scopus 로고
    • Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
    • Yang J.C., Sherry R.M., Steinberg S.M., et al. Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer. J Clin Oncol 21 (2003) 3127-3132
    • (2003) J Clin Oncol , vol.21 , pp. 3127-3132
    • Yang, J.C.1    Sherry, R.M.2    Steinberg, S.M.3
  • 28
    • 35548931472 scopus 로고    scopus 로고
    • Randomized phase II trial of first line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results [abstract]
    • Szczylik C., Demkow T., Staehler M., Rolland F., and Negrier S. Randomized phase II trial of first line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results [abstract]. J Clin Oncol 25 Suppl (2007) 5025
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL , pp. 5025
    • Szczylik, C.1    Demkow, T.2    Staehler, M.3    Rolland, F.4    Negrier, S.5
  • 29
    • 35448934762 scopus 로고    scopus 로고
    • Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study
    • Rixe O., Bukowski R.M., Michaelson M.D., et al. Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study. Lancet Oncol 8 (2007) 975-984
    • (2007) Lancet Oncol , vol.8 , pp. 975-984
    • Rixe, O.1    Bukowski, R.M.2    Michaelson, M.D.3
  • 30
    • 45449118927 scopus 로고    scopus 로고
    • Axitinib (AG013736; AG) in patients with metastatic clear cell renal cell cancer (RCC) refractory to sorafenib [abstract]
    • Rini B., Wilding G., Hudes G., et al. Axitinib (AG013736; AG) in patients with metastatic clear cell renal cell cancer (RCC) refractory to sorafenib [abstract]. Eur J Cancer Suppl 5 (2007) 300
    • (2007) Eur J Cancer Suppl , vol.5 , pp. 300
    • Rini, B.1    Wilding, G.2    Hudes, G.3
  • 31
    • 35548977012 scopus 로고    scopus 로고
    • A phase II trial of RAD001 in patients (Pts) with metastatic renal cell carcinoma (MRCC) [abstract]
    • Jac J., Giessinger S., Khan M., et al. A phase II trial of RAD001 in patients (Pts) with metastatic renal cell carcinoma (MRCC) [abstract]. J Clin Oncol 25 Suppl (2007) 5107
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL , pp. 5107
    • Jac, J.1    Giessinger, S.2    Khan, M.3
  • 32
    • 33746651683 scopus 로고    scopus 로고
    • A phase II trial of RAD001 in patients (Pts) with metastatic renal cell carcinoma (MRCC)
    • Amato R., Misellati A., Khan M., and Chiang S. A phase II trial of RAD001 in patients (Pts) with metastatic renal cell carcinoma (MRCC). J Clin Oncol 24 (2006) 4530
    • (2006) J Clin Oncol , vol.24 , pp. 4530
    • Amato, R.1    Misellati, A.2    Khan, M.3    Chiang, S.4
  • 33
    • 35548997095 scopus 로고    scopus 로고
    • Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): interim results of a phase II randomized discontinuation trial (RDT) [abstract]
    • Hutson T.E., Davis I.D., Machiels J.P., et al. Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): interim results of a phase II randomized discontinuation trial (RDT) [abstract]. J Clin Oncol 25 Suppl (2007) 5031
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL , pp. 5031
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.P.3
  • 34
    • 35548991359 scopus 로고    scopus 로고
    • The Advanced Renal Cell Carcinoma Sorafenib (ARCCS) expanded access trial: safety and efficacy in patients (pts) with non-clear cell (NCC) renal cell carcinoma (RCC) [abstract]
    • Stadler W., and Figlin R. The Advanced Renal Cell Carcinoma Sorafenib (ARCCS) expanded access trial: safety and efficacy in patients (pts) with non-clear cell (NCC) renal cell carcinoma (RCC) [abstract]. J Clin Oncol 25 Suppl (2007) 5036
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL , pp. 5036
    • Stadler, W.1    Figlin, R.2
  • 35
    • 49149108333 scopus 로고    scopus 로고
    • Sorafenib therapy in the management of advanced renal cell carcinoma with brain metastases: results from the ARCCS expanded access program
    • Henderson C.A., Bukowski R.M., Stadler W.M., et al. Sorafenib therapy in the management of advanced renal cell carcinoma with brain metastases: results from the ARCCS expanded access program. Eur Urol Suppl 7 (2008) 245
    • (2008) Eur Urol Suppl , vol.7 , pp. 245
    • Henderson, C.A.1    Bukowski, R.M.2    Stadler, W.M.3
  • 36
    • 33748526494 scopus 로고    scopus 로고
    • Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: impact of patient characteristics and Von Hippel-Lindau gene status
    • Rini B.I., Jaeger E., Weinberg V., et al. Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: impact of patient characteristics and Von Hippel-Lindau gene status. BJU Int 98 (2006) 756-762
    • (2006) BJU Int , vol.98 , pp. 756-762
    • Rini, B.I.1    Jaeger, E.2    Weinberg, V.3
  • 37
    • 44549084875 scopus 로고    scopus 로고
    • Use of Von-Hippel Lindau (VHL) mutation status to predict objective response to vascular endothelial growth factor (VEGF)-targeted therapy in metastatic renal cell carcinoma (RCC) [abstract]
    • Choueiri T.K., Vaziri S.A., Rini P., et al. Use of Von-Hippel Lindau (VHL) mutation status to predict objective response to vascular endothelial growth factor (VEGF)-targeted therapy in metastatic renal cell carcinoma (RCC) [abstract]. J Clin Oncol 25 Suppl (2007) 5012
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL , pp. 5012
    • Choueiri, T.K.1    Vaziri, S.A.2    Rini, P.3
  • 38
    • 20144388609 scopus 로고    scopus 로고
    • Adjuvant treatment with interleukin-2- and interferon-alpha2a-based chemoimmunotherapy in renal cell carcinoma post tumour nephrectomy: results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN)
    • Atzpodien J., Schmitt E., Gertenbach U., et al. Adjuvant treatment with interleukin-2- and interferon-alpha2a-based chemoimmunotherapy in renal cell carcinoma post tumour nephrectomy: results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN). Br J Cancer 92 (2005) 843-846
    • (2005) Br J Cancer , vol.92 , pp. 843-846
    • Atzpodien, J.1    Schmitt, E.2    Gertenbach, U.3
  • 39
    • 0041411517 scopus 로고    scopus 로고
    • Adjuvant high-dose bolus interleukin-2 for patients with high-risk renal cell carcinoma: a cytokine working gr*oup randomized trial
    • Clark J.I., Atkins M.B., Urba W.J., et al. Adjuvant high-dose bolus interleukin-2 for patients with high-risk renal cell carcinoma: a cytokine working gr*oup randomized trial. J Clin Oncol 21 (2003) 3133-3140
    • (2003) J Clin Oncol , vol.21 , pp. 3133-3140
    • Clark, J.I.1    Atkins, M.B.2    Urba, W.J.3
  • 40
    • 10744230275 scopus 로고    scopus 로고
    • Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: phase III, randomised controlled trial
    • Jocham D., Richter A., Hoffmann L., et al. Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: phase III, randomised controlled trial. Lancet 363 (2004) 594-599
    • (2004) Lancet , vol.363 , pp. 594-599
    • Jocham, D.1    Richter, A.2    Hoffmann, L.3
  • 41
    • 33846798279 scopus 로고    scopus 로고
    • Adjuvant therapy in renal cell carcinoma: Where are we?
    • Eisen T. Adjuvant therapy in renal cell carcinoma: Where are we?. Eur Urol Suppl 6 (2007) 492-498
    • (2007) Eur Urol Suppl , vol.6 , pp. 492-498
    • Eisen, T.1
  • 42
    • 49149125964 scopus 로고    scopus 로고
    • US National Institutes of Health. Clinical trials database. Available at: www.clinicaltrials.gov.
    • US National Institutes of Health. Clinical trials database. Available at: www.clinicaltrials.gov.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.