In vivo potential effects of adenovirus type 5 E1A and E1B on lung carcinogenesis and lymphoproliferative inflammation

Journal of Virology

Volumn 82, Issue 16, 2008, Pages 8105-8111

  Yang, Yongping ^a,b   McKerlie, Colin ^c,d   Lu, Zhan ^b   Wang, Lena ^a   Buchwald, Manuel ^b,d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GENE PRODUCT;

ADENOVIRUS 5; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER PATIENT; CELL PROLIFERATION; CHRONIC LUNG DISEASE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IN VIVO STUDY; LUNG CARCINOGENESIS; LYMPHOPROLIFERATIVE DISEASE; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TARGET ORGAN; TRANSGENIC MOUSE; VIRUS GENE;

ADENOVIRIDAE INFECTIONS; ADENOVIRUS E1A PROTEINS; ADENOVIRUS E1B PROTEINS; ANIMALS; APOPTOSIS; CELL TRANSFORMATION, NEOPLASTIC; INFLAMMATION; LUNG NEOPLASMS; LYMPHOPROLIFERATIVE DISORDERS; MICE; MICE, TRANSGENIC; NEOPLASM METASTASIS; RNA, MESSENGER; TRANSGENES; TUMOR SUPPRESSOR PROTEIN P53;

HUMAN ADENOVIRUS TYPE 5; MUS MUSCULUS;

EID: 49149100233     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00536-08     Document Type: Article

References (25)

1. Adrian, T., G. Schafer, M. K. Cooney, J. P. Fox, and R. Wigand. 1988. Persistent enteral infections with adenovirus types 1 and 2 in infants: no evidence of reinfection. Epidemiol. Infect. 101:503-509.
2. Chakrabarti, S., V. Mautner, H. Osman, K. E. Collingham, C. D. Fegan, P. E. Klapper, P. A. Moss, and D. W. Milligan. 2002. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood 100:1619-1627.
3. Endter, C., B. Hartl, T. Spruss, J. Hauber, and T. Dobner. 2005. Blockage of CRM1-dependent nuclear export of the adenovirus type 5 early region 1B 55-kDa protein augments oncogenic transformation of primary rat cells. Oncogene 24:55-64.
4. Fischer, R. S., and M. P. Quinlan. 2000. While E1A can facilitate epithelial cell transformation by several dominant oncogenes, the C-terminus seems only to regulate rac and cdc42 function, but in both epithelial and fibroblastic cells. Virology 269:404-419.
5. Goldrath, A. W., P. V. Sivakumar, M. Glaccum, M. K. Kennedy, M. J. Bevan, C. Benoist, D. Mathis, and E. A. Butz. 2002. Cytokine requirements for acute and basal homeostatic proliferation of naive and memory CD8+ T cells. J. Exp. Med. 195:1515-1522.
6. Green, M., W. S. Wold, J. K. Mackey, and P. Rigden. 1979. Analysis of human tonsil and cancer DNAs and RNAs for DNA sequences of group C (serotypes 1, 2, 5, and 6) human adenoviruses. Proc. Natl. Acad. Sci. USA 76:6606-6610.
7. Hayashi, S. 2002. Latent adenovirus infection in COPD. Chest 121:183S-187S.
8. Hutton, F. G., A. S. Turnell, P. H. Gallimore, and R. J. Grand. 2000. Consequences of disruption of the interaction between p53 and the larger adenovirus early region 1B protein in adenovirus E1 transformed human cells. Oncogene 19:452-462.
9. Jochemsen, A. G., L. T. Peltenburg, M. F. te Pas, C. M. de Wit, J. L. Bos, and A. J. van der Eb. 1987. Activation of adenovirus 5 E1A transcription by region E1B in transformed primary rat cells. EMBO J. 6:3399-3405.
10. Kalvakolanu, D. V. 1999. Virus interception of cytokine-regulated pathways. Trends Microbiol. 7:166-171.
11. Kuwano, K., M. Kawasaki, R. Kunitake, N. Hagimoto, Y. Nomoto, T. Matsuba, Y. Nakanishi, and N. Hara. 1997. Detection of group C adenovirus DNA in small-cell lung cancer with the nested polymerase chain reaction. J. Cancer Res. Clin. Oncol. 123:377-382.
12. Louis, N., C. Evelegh, and F. L. Graham. 1997. Cloning and sequencing of the cellular-viral junctions from the human adenovirus type 5 transformed 293 cell line. Virology 233:423-429.
13. Lowe, S. W., and H. E. Ruley. 1993. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev. 7:535-545.
14. Matsuse, T., S. Hayashi, K. Kuwano, H. Keunecke, W. A. Jefferies, and J. C. Hogg. 1992. Latent adenoviral infection in the pathogenesis of chronic airways obstruction. Am. Rev. Respir. Dis. 146:177-184.
15. Nevels, M., B. Tauber, T. Spruss, H. Wolf, and T. Dobner. 2001. "Hit-and-run" transformation by adenovirus oncogenes. J. Virol. 75:3089-3094.
16. Ploegh, H. L. 1998. Viral strategies of immune evasion. Science 280:248-253.
17. Querido, E., R. C. Marcellus, A. Lai, R. Charbonneau, J. G. Teodoro, G. Ketner, and P. E. Branton. 1997. Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells. J. Virol. 71:3788-3798.
18. Quinlan, M. P. 1994. Enhanced proliferation, growth factor induction and immortalization by adenovirus E1A 12S in the absence of E1B. Oncogene 9:2639-2647.
19. Senear, A. W., and J. B. Lewis. 1986. Morphological transformation of established rodent cell lines by high-level expression of the adenovirus type 2 E1a gene. Mol. Cell. Biol. 6:1253-1260.
20. Sieber, T., and T. Dobner. 2007. Adenovirus type 5 early region 1B 156R protein promotes cell transformation independently of repression of p53-stimulated transcription. J. Virol. 81:95-105.
21. Templeton, S. P., and S. Perlman. 2007. Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM. Immunol. Res. 39:160-172.
22. Van den Elsen, P., A. Houweling, and A. Van der Eb. 1983. Expression of region E1b of human adenoviruses in the absence of region E1a is not sufficient for complete transformation. Virology 128:377-390.
23. Weitzman, M. D., and D. A. Ornelles. 2005. Inactivating intracellular antiviral responses during adenovirus infection. Oncogene 24:7686-7696.
24. Yang, Y., C. McKerlie, S. H. Borenstein, Z. Lu, M. Schito, J. W. Chamberlain, and M. Buchwald. 2002. Transgenic expression in mouse lung reveals distinct biological roles for the adenovirus type 5 E1A 243- and 289-aminoacid proteins. J. Virol. 76:8910-8919.
25. Yew, P. R., and A. J. Berk. 1992. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357:82-85.