Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: Enhanced inhibition by their combination

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 16, 2008, Pages 7592-7598

  Itoh, Tomohiro ^a   Ohguchi, Kenji ^a   Iinuma, Munekazu ^b   Nozawa, Yoshinori ^a   Akao, Yukihiro ^a  

^a GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Allergy; Combinated treatment; Degranulation; Polymethoxy flavone; Rat basophilic leukemia RBL 2H3 cells

Indexed keywords

5,6,7,3',4',5' HEXAMETHOXYFLAVONE; 5,6,8,3',6' PENTAMETHOXYFLAVONE; 6,7,4',5' TETRAMETHOXY 5 MONOHYDROXYFLAVONE; CITRUS FRUIT EXTRACT; CITRUS RETICULATE EXTRACT; FC EPSILON RECEPTOR I; FC RECEPTOR; FLAVONE DERIVATIVE; PHOSPHOLIPASE C GAMMA1; PHOSPHOLIPASE C GAMMA2; PROTEIN KINASE LYN; PROTEIN KINASE SYK; REACTIVE OXYGEN METABOLITE; SILVER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DEGRANULATION; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; HISTAMINE RELEASE; MANDARIN; MAST CELL LEUKEMIA; NONHUMAN; RAT;

ANIMALS; BASOPHILS; CALCIUM; CELL DEGRANULATION; CELL LINE, TUMOR; CITRUS; ENZYME ACTIVATION; FLAVONES; HISTAMINE RELEASE; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, BASOPHILIC, ACUTE; PHOSPHOLIPASE C GAMMA; PROTEIN-TYROSINE KINASES; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, IGG; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

CITRUS; RATTUS;

EID: 49149098259     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.018     Document Type: Article

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