Microwave acceleration in DABAL-Me3-mediated amide formation

Tetrahedron Letters

Volumn 49, Issue 39, 2008, Pages 5687-5688

  Glynn, Daniel ^a   Bernier, David ^a   Woodward, Simon ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AMINE; ESTER; METHOXYAMINE;

ACCELERATION; ARTICLE; CHEMICAL REACTION; MICROWAVE IRRADIATION; SYNTHESIS;

EID: 49149095741     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.07.090     Document Type: Article

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13. 3 (208 mg, 0.8 mmol) and methyl benzoate (136 mg, 125 μl, 1.00 mmol). The microwave vial was sealed with a plastic microwave cap and placed in a CEM discover microwave and irradiated (300 W) at 130 °C for 12 min. The reaction mixture was quenched with 1 M HCl (4 ml), and extracted with DCM (3 × 30 ml), the combined organics were dried over magnesium sulfate and evaporated to yield the crude product. The product was purified using column chromatography with 4:1 petrol/ethyl acetate as eluent.