Arguments against elective single-embryo transfer

Expert Review of Obstetrics and Gynecology

Volumn 3, Issue 4, 2008, Pages 481-486

  Gleicher, Norbert ^a,b   Barad, David H ^a,c  

^a New York and Foundation for Reproductive Medicine   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Cost; Embryo transfer; IVF; Maternal risk; Multiple births; Perinatal risk; Twin pregnancy; Twins

Indexed keywords

ARTICLE; COST EFFECTIVENESS ANALYSIS; ELECTIVE SINGLE EMBRYO TRANSFER; EMBRYO TRANSFER; FERTILIZATION IN VITRO; HEALTH CARE COST; HEALTH CARE SYSTEM; HEALTH INSURANCE; HIGH RISK POPULATION; HUMAN; INFERTILITY; INFORMED CONSENT; MULTIPLE PREGNANCY; PATIENT ATTITUDE; PATIENT SELECTION; PERINATAL PERIOD; PREGNANCY RATE; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; TREATMENT CONTRAINDICATION; TWIN PREGNANCY;

EID: 49149095575     PISSN: 17474108     EISSN: None     Source Type: Journal    
DOI: 10.1586/17474108.3.4.481     Document Type: Article

References (44)

1. Kogan MD, Alexander GR, Kotelchuk M et al. Trends in twin birth outcomes and prenatal care utilization in the United States, 1981-1997. JAMA 283, 335-341 (2000).
2. Fauser BC, Devroey P, Macklon NS. Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet 365, 1807-1816 (2005).
3. Jones Jr HW. Iatrogenic multiple births: a 2003 checkup. Fertil. Steril. 87, 453-455 (2007).
4. Gleicher N, Oleske DM, Tur Kaspa I, Vidali A, Karande V. Reducing the risk of high-order multiple pregnancy after ovarian stimulation with gonadotropins. N. Engl. J. Med. 343, 2-7 (2000).
5. Dickey RP, Taylor AN, Lu PY, Sartor BM, Rye BH, Pyrzak R. Risk factors for high-order multiple pregnancy and multiple birth after controlled ovarian hyperstimulation: results of 4,062 intrauterine insemination cycles. Fertil. Steril. 83, 671-683 (2005).
6. Dickey RP. A year of inaction on high-order multiple pregnancies due to ovulation induction. Fertil. Steril. 79, 14-16 (2003).
7. Toner JP. Progress we can be proud of: U.S. trends in assisted reproduction over the first 20 years. Fertil. Steril. 78, 943-950 (2002).
8. Gleicher N. Safety issues in assisted reproduction technology. A rebuttal. Hum. Reprod. 18, 1765-1766 (2003).
9. Templeton A, Morris JK. Reducing the risk of multiple births by transfer of two embryos after in vitro fertilization. N. Engl. J. Med. 339, 573-577 (1998).
10. American Society for Reproductive Medicine. Guidelines on number of embryos transferred. Fertil. Steril. 82, 773-774 (2004).
11. Jones Jr HW. Multiple births: how are we doing? Fertil. Steril. 79, 17-21 (2003).
12. Bardis N, Maruthini D, Balen AH. Modes of conception and multiple pregnancy: a national survey of babies born during one week in 2003 in the United Kingdom. Fertil. Steril. 84, 1727-1732 (2005).
13. Tiitinen A, Unkila-Kallio L, Halttunen M, Hyden-Granskog C. Impact of elective single embryo transfer on the twin pregnancy rate. Hum. Reprod. 18, 1449-1453 (2003).
14. Conde-Agudelo A, Belizan JM, Lindmark G. Maternal morbidity an mortality associated with multiple gestations. Obstet. Gynecol. 95, 899-904 (2000).
15. Ombelet W, Martens G, De Sutter P et al. Perinatal outcome of 12,021 singleton and 3108 twin births after non-IVF assisted reproduction: a cohort study. Hum. Reprod. 21, 1025-1032 (2006).
16. Seoud MA, Toner JP, Kruithoff C, Muasher SJ. Outcome of twin, triplet and quadruplet in vitro fertilization pregnancies: the Norfolk experience. Fertil. Steril. 57, 825-834 (1992).
17. Pinborg A. IVF/ICSI twin pregnancies: risks and prevention. Hum. Reprod. Update 11, 575-593 (2005).
18. Kjelberg AT, Carlsson P, Bergh C. Randomized single versus double embryo transfer obstetrics and pediatric outcome and cost-effectiveness analysis. Hum. Reprod. 21, 210-216 (2006).
19. De Neubourg D, Gerris J. What about the remaining twins since single-embryo transfer? How far can (should) we go? Hum. Reprod. 21, 843-846 (2006).
20. Karlström PO, Bergh C. Reducing the number of embryos transferred in Sweden - impact on delivery and multiple birth rates. Hum. Reprod. 22, 2202-2207 (2007).
21. Lieberman B, Ali R, Rangarajan S. Towards the elective replacement of a single embryo (eSET) in the United Kingdom. Hum. Fertil. (Camb.) 10, 123-127 (2007).
22. Gleicher N, Barad D. Twin pregnancy, contrary to consensus, is a desirable outcome in infertility. Fertil. Steril. PMID: 18439598 (2008) (Epub ahead of print).
23. Gleicher N, Campbell DP, Chan CL et al. The desire for multiple births in couples with infertility problems contradicts present practice patterns. Hum. Reprod. 10, 1079-1084 (1995).
24. Ryan GL, Zhang SH, Fokras A, Syrop CH, Van Voorhis BJ. The desire of infertile patients for multiple births. Fertil. Steril. 81, 500-504 (2004).
25. Newton CR, McBride J, Feyles V, Tekpetey F, Power S. Factors affecting patients' attitudes toward single- and multiple-embryo transfer. Fertil. Steril. 87, 269-278 (2007).
26. Stillman RJ. A 47-year old woman with fertility problems who desires a multiple pregnancy. JAMA 297, 858-867 (2007).
27. Scotland GS, McNamee P, Peddie VL, Bhattacharaya S. Safety versus success in elective single embryo transfer: women's preferences for outcomes of in vitro fertilization. BJOG 114, 977-983 (2007).
28. Callahan TL, Hall JE, Ettner SL, Christiansen CL, Greene MF, Crowley Jr WF. The economic impact of multiple gestation pregnancies and the contribution of assisted-reproduction techniques on their incidence. N. Engl. J. Med. 331, 244-249 (1994).
29. Kinzler WL, Ananth CV, Vintzileos AM. Medical and economic effects of twin gestation. J. Soc. Gynecol. Investig. 7, 321-327 (2000).
30. Koivurova S, Hartikainen A-L, Gissler M, Hemminki E, Järvelin M-J. Post-neonatal hospitalization and health care costs among IVF children: a 7-year follow-up study. Hum. Reprod. 22, 2136-2141 (2007).
31. Luke B, Bigger HR, Leurgans S, Sietscma D. The cost of prematurity: a case-control study of twins vs singletons. Am. J. Public Health 86, 809-814 (1996).
32. Van der Gaag N, De Jong AH. Population scenarios for the European union: regional scenarios. Maandstat. Bevolking 45, 17-31 (1997).
33. Hoorens S, Gallo F, Cave JAK, Grant JC. Can assisted reproductive technologies help offset population ageing? An assessment of the demographic and economic impact of ART in Denmark and UK. Hum. Reprod. 22, 2471-2475 (2007).
34. Gleicher N. Strategies to improve insurance coverage for infertility services. Fertil. Steril. 70, 1006-1008 (1998).
35. Jain T, Hornstein MD. Disparities in access to infertility services in a state with mandated insurance coverage. Fertil. Steril. 84, 221-223 (2005).
36. Gleicher N, Weghofer A, Barad A. A formal comparison of the practice of assisted reproductive technologies between Europe and the USA. Hum. Reprod. 21, 1945-1950 (2006).
37. Gleicher N, Weghofer A, Barad D. Update on the comparison of assisted reproduction outcomes between Europe and the USA: the 2002 data. Fertil. Steril. 87, 1301-1305 (2007).
38. Saideen P, Sunderström P. Would legislation imposing single embryo transfer be a feasible way to reduce the rate of multiple pregnancies after IVF treatment? Hum. Reprod. 19, 1046-1048 (2005).
39. Ryan GL, Sparks AE, Sipe CS, Syrop CH, Dokras A, Van Voorhis BJ. A mandatory single blastocyst transfer policy with educational campaign in a United States IVF program reduces multiple gestation rates without sacrificing pregnancy rates. Fertil. Steril. 88, 354-360 (2007).
40. Gleicher N, Barad D. The relative myth of elective single embryo transfer. Hum. Reprod. 21, 1337-1344 (2006).
41. van Wely M, Twisk M, Mol BW, van der Veen F. Is twin pregnancy necessarily and adverse outcome of assisted reproductive technologies? Hum. Reprod. 21, 2736-2738 (2006).
42. Belaisch-Allart J. Is twin pregnancy necessarily an adverse outcome of assisted reproductive technologies? Hum. Reprod. 22, 1495 (2007).
43. Gleicher N, Weghofer A, Barad D. Preimplantation genetic screening: "established" and ready for prime time? Fertil. Steril. 89(4), 780-788 (2008).
44. Mastenbroek S, Twisk M, van Echten-Arends J et al. In vitro fertilization with preimplantation genetic screening. N. Engl. J. Med. 357, 9-17 (2007).