Dictazolines A and B, Bisspiroimidazolidinones from the Marine Sponge Smenospongia cerebriformis

Journal of Natural Products

Volumn 71, Issue 7, 2008, Pages 1287-1290

  Dai, Jingqiu ^a   Jiménez, Jorge I ^d   Kelly, Michelle ^c   Barnes, Shawn ^b   Lorenzo, Patricia ^b   Williams, Philip ^a,b  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^c NATIONAL INSTITUTE OF WATER AND ATMOSPHERIC RESEARCH   (New Zealand)

^d AgraQuest Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICTAZOLINE A; DICTAZOLINE B; IMIDAZOLIDINE DERIVATIVE; NATURAL PRODUCT; PROTEIN KINASE C; TUBASTRINDOLE A; TUBASTRINDOLE B;

ARTICLE; DRUG ISOLATION; ENZYME INHIBITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SMENOSPONGIA CEREBRIFORMIS; SPONGE (PORIFERA);

ANIMALS; ANTHOZOA; IMIDAZOLES; INDOLES; MARINE BIOLOGY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PORIFERA; SPIRO COMPOUNDS;

ALCYONACEA; SMENOSPONGIA;

EID: 49049102320     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np8001018     Document Type: Article

References (6)

1. Iwagawa, T.; Miyazaki, M.; Okamura, H.; Nakatani, M.; Doe, M.; Takemura, K. Tetrahedron Lett. 2003, 44, 2533-2535.
2. The structural depictions of 1-4 in this paper are drawn in accordance with IUPAC rules, in which the lowest octant is assigned an R* configuration in molecules where the absolute configuration is unknown. See: Cross, L. C.; Klyne, W. Pure Appl. Chem. 1976, 45, 11-30.
3. It should be noted that compound 5 is the well-known sponge metabolite aplysinopsin often isolated from dictyoceratid and astrophorid sponges. See: Kauzlauskas, R.; Murphy, P. T.; Quinn, R. J.; Wells, R. J. Tetrahedron Lett. 1977, 61-64.
4. Koh, E. G. L.; Sweatman, H. J. Exp. Mar. BM. 2000, 251, 141-160.
5. Mancini, I.; Guella, G.; Zibrowius, H.; Pietra, F. Tetrahedron 2003, 59, 8757-8762.
6. Hardy, J. Curr. Alzheimer Res. 2006, 3, 71-73.