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Volumn 43, Issue 6, 2008, Pages 664-668

In vitro metabolic interconversion between baicalin and baicalein in the liver, kidney, intestine and bladder of rat

Author keywords

Baicalein; Baicalin; In vitro metabolism

Indexed keywords

ANTIINFECTIVE AGENT; ANTIOXIDANT; BAICALEIN; BAICALIN; BETA GLUCURONIDASE; FLAVANONE DERIVATIVE; FLAVONOID; GLUCURONOSYLTRANSFERASE;

EID: 49049100463     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (8)

References (14)
  • 1
    • 33748922624 scopus 로고    scopus 로고
    • Effect of baicalin on HSP70 expression of hippocampal neurons in focal brain ischemia-reperfusion injury rat [J]
    • Liu P, Wang JY, LI Q, et al. Effect of baicalin on HSP70 expression of hippocampal neurons in focal brain ischemia-reperfusion injury rat [J]. Acta Pharm Sin, 2006,41:619-624.
    • (2006) Acta Pharm Sin , vol.41 , pp. 619-624
    • Liu, P.1    Wang, J.Y.2    LI, Q.3
  • 2
    • 0347754994 scopus 로고    scopus 로고
    • The current situation in pharmacological study on baicalin [J]
    • Zhang XP, Tian H, Cheng QH. The current situation in pharmacological study on baicalin [J]. Chin Pharmacol Bull, 2003,19:1212-1215.
    • (2003) Chin Pharmacol Bull , vol.19 , pp. 1212-1215
    • Zhang, X.P.1    Tian, H.2    Cheng, Q.H.3
  • 3
    • 0035684395 scopus 로고    scopus 로고
    • Review in pharmacological study of baicalein [J]
    • Zhang XP, Li ZF, Liu XG. Review in pharmacological study of baicalein [J]. Chin Pharmacol Bull, 2001,17:711-713.
    • (2001) Chin Pharmacol Bull , vol.17 , pp. 711-713
    • Zhang, X.P.1    Li, Z.F.2    Liu, X.G.3
  • 4
    • 0034534704 scopus 로고    scopus 로고
    • Balicalin, the predominant flavone glucuronide of Scutellariae Radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form [J]
    • Akao T, Kawabata K, Yanagisawa E, et al. Balicalin, the predominant flavone glucuronide of Scutellariae Radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form [J]. J Pharm Pharmacol, 2000,12:1563-1568.
    • (2000) J Pharm Pharmacol , vol.12 , pp. 1563-1568
    • Akao, T.1    Kawabata, K.2    Yanagisawa, E.3
  • 5
    • 33745024058 scopus 로고    scopus 로고
    • Investigation of the absorption mechanisms of baicalin and baicalein in rats [J]
    • Liu TM, Jiang XH. Investigation of the absorption mechanisms of baicalin and baicalein in rats [J]. J Pharm Sci, 2006,6:1326-1333.
    • (2006) J Pharm Sci , vol.6 , pp. 1326-1333
    • Liu, T.M.1    Jiang, X.H.2
  • 6
    • 27644442245 scopus 로고    scopus 로고
    • Absorption and enterohepatic circulation of baicalin in rats [J]
    • Xing J, Chen XY, Zhong DF. Absorption and enterohepatic circulation of baicalin in rats [J]. Life Sci, 2005,78:140-146.
    • (2005) Life Sci , vol.78 , pp. 140-146
    • Xing, J.1    Chen, X.Y.2    Zhong, D.F.3
  • 7
    • 21644436299 scopus 로고    scopus 로고
    • Enteric excretion of baicalein, a flavone of Scutellaria Radix, via lucuronidation in rat: Involvement of multidrug resistance-associated protein 2 [J]
    • Akao T, Sakashita Y, Hanada M, et al. Enteric excretion of baicalein, a flavone of Scutellaria Radix, via lucuronidation in rat: involvement of multidrug resistance-associated protein 2 [J]. Pharm Res, 2004,21:2120-2126.
    • (2004) Pharm Res , vol.21 , pp. 2120-2126
    • Akao, T.1    Sakashita, Y.2    Hanada, M.3
  • 8
    • 33751330657 scopus 로고    scopus 로고
    • Liquid chromatography with tandem mass spectrometry for the simultaneous determination of baicalein, baicalin, oroxylin A and wogonin in rat plasma [J]
    • Kim YH, Jeong DW, Paek IB, et al. Liquid chromatography with tandem mass spectrometry for the simultaneous determination of baicalein, baicalin, oroxylin A and wogonin in rat plasma [J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2006,844:261-267.
    • (2006) J Chromatogr B Analyt Technol Biomed Life Sci , vol.844 , pp. 261-267
    • Kim, Y.H.1    Jeong, D.W.2    Paek, I.B.3
  • 9
    • 0344642935 scopus 로고    scopus 로고
    • Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats [J]
    • Lai MY, Hsiu SL, Tsai SY, et al. Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats [J]. J Pharm Pharmacol, 2003,55:205-209.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 205-209
    • Lai, M.Y.1    Hsiu, S.L.2    Tsai, S.Y.3
  • 10
    • 32644486652 scopus 로고    scopus 로고
    • HPLC with electrochemical detection to examine the pharmacokinetics of baicalin and baicalein in rat plasma after oral administration of a Kampo medicine [J]
    • Kotani A, Kojima S, Hakamata H, et al. HPLC with electrochemical detection to examine the pharmacokinetics of baicalin and baicalein in rat plasma after oral administration of a Kampo medicine [J]. Anal Biochem, 2006,1:99-104.
    • (2006) Anal Biochem , vol.1 , pp. 99-104
    • Kotani, A.1    Kojima, S.2    Hakamata, H.3
  • 11
    • 34548435160 scopus 로고    scopus 로고
    • Pharmacokinetics of flavonoids from Xiexin decoction in rats [J]
    • Yan JC, Liu ZM, Wang TM, et al. Pharmacokinetics of flavonoids from Xiexin decoction in rats [J]. Acta Pharm Sin, 2007,7:722-729.
    • (2007) Acta Pharm Sin , vol.7 , pp. 722-729
    • Yan, J.C.1    Liu, Z.M.2    Wang, T.M.3
  • 12
    • 33747840664 scopus 로고    scopus 로고
    • Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid [J]
    • Miles KK, Kessler FK, Smith PC, et al. Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid [J]. Drug Metab Dispos, 2006,9:1632-1639.
    • (2006) Drug Metab Dispos , vol.9 , pp. 1632-1639
    • Miles, K.K.1    Kessler, F.K.2    Smith, P.C.3
  • 13
    • 0017686331 scopus 로고    scopus 로고
    • Rod TO, Midtvedt T. Origin of intestinal beta-glucuronidase in germfree, monocontaminated and conventional rats [J]. Acta Pathol Microbiol Scand [B]. 1977,4:271-276.
    • Rod TO, Midtvedt T. Origin of intestinal beta-glucuronidase in germfree, monocontaminated and conventional rats [J]. Acta Pathol Microbiol Scand [B]. 1977,4:271-276.
  • 14
    • 33845424456 scopus 로고    scopus 로고
    • Involvement of UDP-glucuronosyltransferases in the extensive liver and intestinal first-pass metabolism of flavonoid baicalein [J]
    • Zhang L, Li G, Zuo Z. Involvement of UDP-glucuronosyltransferases in the extensive liver and intestinal first-pass metabolism of flavonoid baicalein [J]. Pharm Res, 2007,24:81-89.
    • (2007) Pharm Res , vol.24 , pp. 81-89
    • Zhang, L.1    Li, G.2    Zuo, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.