Overexpression of the Na-K-ATPase α2-subunit improves lung liquid clearance during ventilation-induced lung injury

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 294, Issue 6, 2008, Pages

  Adir, Yochai ^a,b   Welch, Lynn C ^a   Dumasius, Vidas ^a   Factor, Phillip ^c   Sznajder, Jacob I ^a   Ridge, Karen M ^a,d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c Columbia University College of Physicians and Surgeons ^*  (United States)

^d JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Experimental models; Gene therapy

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); OUABAIN; SODIUM POTASSIUM ADENOSINE TRIPHOSPHATASE ALPHA2; UNCLASSIFIED DRUG; ATP1A2 PROTEIN, RAT;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; BASOLATERAL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBUNIT; LUNG ALVEOLUS EPITHELIUM; LUNG CLEARANCE; LUNG INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VENTILATOR; VIRAL GENE DELIVERY SYSTEM; ANIMAL; BIOSYNTHESIS; GENE TRANSFER; LUNG ALVEOLUS; LUNG DISEASE; LUNG EXTRAVASCULAR FLUID; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; EXTRAVASCULAR LUNG WATER; GENE TRANSFER TECHNIQUES; LUNG DISEASES; PULMONARY ALVEOLI; RATS; RESPIRATION, ARTIFICIAL; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 48949119344     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00076.2007     Document Type: Article

References (33)

1. Adir Y, Factor P, Dumasius V, Ridge KM, Sznajder JI. Na,K-ATPase gene transfer increases liquid clearance during ventilation-induced lung injury. Am J Respir Crit Care Med 168: 1445-1448, 2003.
2. Azzam ZS, Dumasius V, Saldias FJ, Adir Y, Sznajder JI, Factor P. Na,K-ATPase overexpression improves alveolar fluid clearance in a rat model of elevated left atrial pressure. Circulation 105: 497-501, 2002.
3. +-ATPase activity by membrane insertion of α-subunits in lung alveolar cells. Am J Physiol Lung Cell Mol Physiol 276: L20-L27, 1999.
4. Borok Z, Liebler JM, Lubman RL, Foster MJ, Zhou B, Li X, Zabski SM, Kim KJ, Crandall ED. Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol 282: L599-L608, 2002.
5. Carlton DP, Cummings JJ, Scheerer RG, Poulain FR, Bland RD. Lung overexpansion increases pulmonary microvascular protein permeability in young lambs. J Appl Physiol 69: 577-583, 1990.
6. Corbridge TC, Wood LD, Crawford GP, Chudoba MJ, Yanos J, Sznajder JI. Adverse effects of large tidal volume and low PEEP in canine acid aspiration. Am Rev Respir Dis 142: 311-315, 1990.
7. Crandall ED, Matthay MA. Alveolar epithelial transport. Basic science to clinical medicine. Am J Respir Crit Care Med 163: 1021-1029, 2001.
8. Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI. Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta. J Clin Invest 111: 1057-1064, 2003.
9. Dreyfuss D, Basset G, Soler P, Saumon G. Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats. Am Rev Respir Dis 132: 880-884, 1985.
10. +-ATPase beta1 subunit gene improves alveolar fluid clearance and survival in hyperoxic rats. Hum Gene Ther 11: 2231-2242, 2000.
11. Factor P, Mendez M, Mutlu GM, Dumasius V. Acute hyperoxic lung injury does not impede adenoviral-mediated alveolar gene transfer. Am J Respir Crit Care Med 165: 521-526, 2002.
12. Factor P, Saldias F, Ridge K, Dumasius V, Zabner J, Jaffe HA, Blanco G, Barnard M, Mercer R, Perrin R, Sznajder JI. Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene. J Clin Invest 102: 1421-1430, 1998.
13. Johnson M, Widdicombe J, Allen L, Barbry P, Dobbs L. Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis. Proc Natl Acad Sci USA 99: 1966-1971, 2002.
14. Kim IH, Jozkowicz A, Piedra PA, Oka K, Chan L. Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci USA 98: 13282-13287, 2001.
15. Lecuona E, Saldias F, Comellas A, Ridge K, Guerrero C, Sznajder JI. Ventilator-associated lung injury decreases lung ability to clear edema and downregulates alveolar epithelial cell Na,K-adenosine triphosphatase function. Chest 116: 29S-30S, 1999.
16. Lecuona E, Saldias F, Comellas A, Ridge K, Guerrero C, Sznajder JI. Ventilator-associated lung injury decreases lung ability to clear edema in rats. Am J Respir Crit Care Med 159: 603-609, 1999.
17. Litvan J, Briva A, Wilson MS, Budinger GR, Sznajder JI, Ridge KM. Beta-adrenergic receptor stimulation and adenoviral overexpression of superoxide dismutase prevent the hypoxia-mediated decrease in Na,K-ATPase and alveolar fluid reabsorption. J Biol Chem 281: 19892-19898, 2006.
18. +)-ATPase in rat adipocytes. Relation to insulin stimulation of the enzyme. J Biol Chem 260: 1177-1184, 1985.
19. +-ATPase beta1 subunit using electroporation increases lung liquid clearance. Am J Respir Crit Care Med 171: 204-211, 2005.
20. Matthay MA, Landolt CC, Staub NC. Differential liquid and protein clearance from the alveoli of anesthetized sheep. J Appl Physiol 53: 96-104, 1982.
21. Mutlu GM, Sznajder JI. Mechanisms of pulmonary edema clearance. Am J Physiol Lung Cell Mol Physiol 289: L685-L695, 2005.
22. Orlowski J, Lingrel JB. Differential expression of the Na,K-ATPase alpha1 and alpha2 genes in murine myogenic cell line. J Biol Chem 263: 17817-17821, 1988.
23. Ranieri VM, Giunta F, Suter PM, Slutsky AS. Mechanical ventilation as a mediator of multisystem organ failure in acute respiratory distress syndrome. JAMA 284: 43-44, 2000.
24. Ridge K, Dada L, Lecuona E, Bertorello A, Katz A, Mochly-Rosen D, Sznajder J. Dopamine-induced exocytosis of the Na,K-ATPase is dependent on the activation of protein kinase C delta and epsilon. Mol Biol Cell 13: 1381-1389, 2002.
25. Ridge KM, Olivera WG, Saldias F, Azzam Z, Horowitz S, Rutschman DH, Dumasius V, Factor P, Sznajder JI. Alveolar type 1 cells express the alpha2 Na,K-ATPase, which contributes to lung liquid clearance. Circ Res 92: 453-460, 2003.
26. Ridge KM, Rutschman DH, Factor P, Katz AI, Bertorello AM, Sznajder JL. Differential expression of Na-K-ATPase isoforms in rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 273: L246-L255, 1997.
27. Russo JJ, Manuli MA, Ismail-Beigi F, Sweadner KJ, Edelman IS. Na-K-ATPase in adipocyte differentiation in culture. Am J Physiol Cell Physiol 259: C968-C977, 1990.
28. Rutschman DH, Olivera W, Sznajder JI. Active transport and passive liquid movement in isolated perfused rat lungs. J Appl Physiol 75: 1574-1580, 1993.
29. Shull MM, Pugh DG, Lingrel JB. Characterization of the human Na,K-ATPase alpha 2 gene and identification of intragenic restriction fragment length polymorphisms. J Biol Chem 264: 17532-17543, 1989.
30. Shyjan AW, Levenson R. Antisera specific for the alpha 1, alpha 2, alpha 3, and beta subunits of the Na,K-ATPase: differential expression of alpha and beta subunits in rat tissue membranes. Biochemistry 28: 4531-4535, 1989.
31. Skou JC. The Na-K pump. NIPS 7: 95-100, 1992.
32. Sznajder JI, Factor P, Ingbar DH. Invited review: lung edema clearance: role of Na-K-ATPase. J Appl Physiol 93: 1860-1866, 2002.
33. Ware LB, Matthay M. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 163: 1376-1383, 2001.