Identification and characterization of a long isoform of human IFT80, IFT80-L

Biochemical and Biophysical Research Communications

Volumn 373, Issue 4, 2008, Pages 653-658

  Huang, Weihua ^a   Kane, Justin K ^a   Li, Ming D ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Cell differentiation; Gene expression; Gene suppression; IFT; IFT80; IFT80 L; siRNA

Indexed keywords

GENE PRODUCT; IFT80 L PROTEIN; IFT80 PROTEIN; MICROTUBULE PROTEIN; RING FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; FLAGELLUM; GENE; GENE EXPRESSION; GENE STRUCTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; IFT80 GENE; INTRACELLULAR TRANSPORT; INTRAFLAGELLAR TRANSPORT; JEUNE ASPHYXIATING THORACIC DYSTROPHY; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEQUENCE ANALYSIS; THORAX MALFORMATION; TRIM59 GENE;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; GENE EXPRESSION; HUMANS; MEMBRANE PROTEINS; METALLOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTOR; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RATS; RNA, SMALL INTERFERING;

EID: 48949115078     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.06.085     Document Type: Article

References (30)

1. Rosenbaum J.L., and Witman G.B. Intraflagellar transport. Nat. Rev. Mol. Cell Biol. 3 (2002) 813-825
2. Scholey J.M. Intraflagellar transport. Annu. Rev. Cell Dev. Biol. 19 (2003) 423-443
3. Singla V., and Reiter J.F. The primary cilium as the cell's antenna: signaling at a sensory organelle. Science 313 (2006) 629-633
4. Christensen S.T., Pedersen L.B., Schneider L., et al. Sensory cilia and integration of signal transduction in human health and disease. Traffic 8 (2007) 97-109
5. Scholey J.M., and Anderson K.V. Intraflagellar transport and cilium-based signaling. Cell 125 (2006) 439-442
6. Wang Q., Pan J., and Snell W.J. Intraflagellar transport particles participate directly in cilium-generated signaling in Chlamydomonas. Cell 125 (2006) 549-562
7. Salisbury J.L. Primary cilia: putting sensors together. Curr. Biol. 14 (2004) R765-R767
8. Pazour G.J., and Witman G.B. The vertebrate primary cilium is a sensory organelle. Curr. Opin. Cell Biol. 15 (2003) 105-110
9. Kozminski K.G., Johnson K.A., Forscher P., et al. A motility in the eukaryotic flagellum unrelated to flagellar beating. Proc. Natl. Acad. Sci. USA 90 (1993) 5519-5523
10. Cole D.G. The intraflagellar transport machinery of Chlamydomonas reinhardtii. Traffic 4 (2003) 435-442
11. Jekely G., and Arendt D. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. Bioessays 28 (2006) 191-198
12. Blacque O.E., Perens E.A., Boroevich K.A., et al. Functional genomics of the cilium, a sensory organelle. Curr. Biol. 15 (2005) 935-941
13. Sun Z., Amsterdam A., Pazour G.J., et al. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development 131 (2004) 4085-4093
14. Han Y.G., Kwok B.H., and Kernan M.J. Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. Curr. Biol. 13 (2003) 1679-1686
15. Afzelius B.A. Cilia-related diseases. J. Pathol. 204 (2004) 470-477
16. Chang R., Xu X., and Li M.D. Molecular cloning, mapping and characterization of a novel mouse RING finger gene, Mrf1. Gene 291 (2002) 241-249
17. Beales P.L., Bland E., Tobin J.L., et al. IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy. Nat. Genet. 39 (2007) 727-729
18. Avidor-Reiss T., Maer A.M., Koundakjian E., et al. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Cell 117 (2004) 527-539
19. Fujiwara M., Ishihara T., and Katsura I. A novel WD40 protein, CHE-2, acts cell-autonomously in the formation of C. elegans sensory cilia. Development 126 (1999) 4839-4848
20. Li J.B., Gerdes J.M., Haycraft C.J., et al. Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell 117 (2004) 541-552
21. Ostrowski L.E., Blackburn K., Radde K.M., et al. A proteomic analysis of human cilia: identification of novel components. Mol. Cell Proteomics 1 (2002) 451-465
22. Nagase T., Kikuno R., Ishikawa K.I., et al. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7 (2000) 65-73
23. Laurencon A., Dubruille R., Efimenko E., et al. Identification of novel regulatory factor X (RFX) target genes by comparative genomics in Drosophila species. Genome Biol. 8 (2007) R195
24. Chen N., Mah A., Blacque O.E., et al. Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics. Genome Biol. 7 (2006) R126
25. Mikami A., Tynan S.H., Hama T., et al. Molecular structure of cytoplasmic dynein 2 and its distribution in neuronal and ciliated cells. J. Cell Sci. 115 (2002) 4801-4808
26. Murcia N.S., Richards W.G., Yoder B.K., et al. The oak ridge polycystic kidney (orpk) disease gene is required for left-right axis determination. Development 127 (2000) 2347-2355
27. Baas D., Meiniel A., Benadiba C., et al. A deficiency in RFX3 causes hydrocephalus associated with abnormal differentiation of ependymal cells. Eur. J. Neurosci. 24 (2006) 1020-1030
28. Qin H., Rosenbaum J.L., and Barr M.M. An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons. Curr. Biol. 11 (2001) 457-461
29. Ou G., Blacque O.E., Snow J.J., et al. Functional coordination of intraflagellar transport motors. Nature 436 (2005) 583-587
30. Huangfu D., Liu A., Rakeman A.S., et al. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426 (2003) 83-87