Outcome of pregnancies at risk for neonatal hemochromatosis is improved by treatment with high-dose intravenous immunoglobulin

Pediatrics

Volumn 121, Issue 6, 2008, Pages

  Whitington, Peter F ^a,b   Kelly, Susan ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b CHILDREN'S MEMORIAL HOSPITAL   (United States)

Author keywords

Fetal mortality; Intravenous immunoglobulin; Iron overload; Maternal antibodies; Neonatal death

Indexed keywords

ANTIOXIDANT; CHELATING AGENT; IMMUNOGLOBULIN;

ADULT; ALLOIMMUNITY; ARTICLE; ASEPTIC MENINGITIS; CHELATION THERAPY; DISEASE SEVERITY; DRUG MEGADOSE; DRUG WITHDRAWAL; FEMALE; FETUS DISTRESS; FETUS WASTAGE; GESTATION PERIOD; GESTATIONAL AGE; HEADACHE; HEMOCHROMATOSIS; HIGH RISK PREGNANCY; HUMAN; HYPOTHYROIDISM; INFANT; INFORMATION PROCESSING; LIVER DYSFUNCTION; LIVER FAILURE; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALAISE; MYALGIA; NAUSEA; NEONATAL HEMOCHROMATOSIS; NEWBORN DEATH; PREGNANCY OUTCOME; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; RISK ASSESSMENT; THORAX PAIN; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT INDICATION; TREATMENT OUTCOME; URTICARIA; MALE; NEWBORN; PREGNANCY;

FEMALE; HEMOCHROMATOSIS; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INFANT, NEWBORN; MALE; PREGNANCY; PREGNANCY OUTCOME; PROSPECTIVE STUDIES;

EID: 48949090831     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2007-3107     Document Type: Article

References (31)

1. Knisely AS, Mieli-Vergani G, Whitington PF. Neonatal hemochromatosis. Gastroenterol Clin North Am. 2003;32(3):877-889
2. Silver MM, Beverley DW, Valberg LS, Cutz E, Phillips MJ, Shaheed WA. Perinatal hemochromatosis. Clinical, morphologic, and quantitative iron studies. Am J Pathol. 1987;128(3): 538-554
3. Whitington PF. Fetal and infantile hemochromatosis. Hepatol- ogy.2006;43(4):654-660
4. Whitington PF. Neonatal hemochromatosis: a congenital allo- immune hepatitis. Semin Liver Dis. 2007;27(3):243-250
5. Hoogstraten J, de Sa DJ, Knisely AS. Fetal liver disease may precede extrahepatic siderosis in neonatal hemochromatosis. Gastroenterology. 1990;98(6):1699-1701
6. Whitington PF, Kelly S, Ekong UD. Neonatal hemochromatosis: fetal liver disease leading to liver failure in the fetus and newborn. Pediatr Transplant. 2005;9(5):640-645
7. Kelly AL, Lunt PW, Rodrigues F, et al. Classification and genetic features of neonatal haemochromatosis: a study of 27 affected pedigrees and molecular analysis of genes implicated in iron metabolism. J Med Genet. 2001;38(9):599-610
8. Whitington PF, Hibbard JU. High-dose immunoglobulin during pregnancy for recurrent neonatal haemochromatosis. Lancet. 2004;364(9446):1690-1698
9. Shneider BL. Genetic counseling in neonatal hemochromato- sis. J Pediatr Gastroenterol Nutr. 2002;34(3):328
10. Whitington PF, Malladi P. Neonatal hemochromatosis: is it an alloimmune disease? J Pediatr Gastroenterol Nutr. 2005;40(5): 544 -549
11. Branch DW, Porter TF, Paidas MJ, Belfort MA, Gonik B. Obstetric uses of intravenous immunoglobulin: successes, failures, and promises. J Allergy Clin Immunol. 2001;108(4 suppl):S133-S138
12. Kazatchkine MD, Kaveri SV. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med. 2001;345(10):747-755
13. Allen K, Whitington PF. Evaluation of liver function. In: Polin R, Fox W, eds. Fetal and Neonatal Physiology. 2nd ed. Philadelphia, PA: WB Saunders; 1998:1530-1552
14. Sigurdsson L, Reyes J, Kocoshis SA, Hansen TW, Rosh J, Knisely AS. Neonatal hemochromatosis: outcomes of pharma- cologic and surgical therapies. J Pediatr Gastroenterol Nutr. 1998; 26(1):85-89
15. Vohra P, Haller C, Emre S, et al. Neonatal hemochromatosis: the importance of early recognition of liver failure. J Pediatr. 2000;136(4):537-541
16. Gitlin D. Normal biology of alpha-fetoprotein. Ann N Y Acad Sci. 1975;259:7-16
17. Obiekwe BC, Malek N, Kitau MJ, Chard T. Maternal and fetal alphafetoprotein (AFP) levels at term: relation to sex, weight and gestation of the infant. Acta Obstet Gynecol Scand. 1985; 64(3):251-253
18. Siddappa AM, Rao R, Long JD, Widness JA, Georgieff MK. The assessment of newborn iron stores at birth: a review of the literature and standards for ferritin concentrations. Neonatology. 2007;92(2):73-82
19. Flynn DM, Mohan N, McKiernan P, et al. Progress in treatment and outcome for children with neonatal haemochromatosis. Arch Dis Child Fetal Neonatal Ed. 2003;88(2):F124-F127
20. Pietrangelo A. Hereditary hemochromatosis-a new look at an old disease. N Engl J Med. 2004;350(23):2383-2397
21. Heffron T, Pillen T, Welch D, et al. Medical and surgical treatment of neonatal hemochromatosis: single center experience. Pediatr Transplant. 2007;11(4):374-378
22. Rodrigues F, Kallas M, Nash R, et al. Neonatal hemochromatosis-medical treatment vs. transplantation: the King's experience. Liver Transpl. 2005;11(11):1417-1424
23. Grabhorn E, Richter A, Burdelski M, Rogiers X, Ganschow R. Neonatal hemochromatosis: long-term experience with favorable outcome. Pediatrics. 2006;118(5):2060-2065
24. Sundaram SS, Alonso EM, Whitington PF. Liver transplantation in neonates. Liver Transpl. 2003;9(8):783-788
25. Leonis MA, Balistreri WF. Neonatal hemochromatosis: it's OK to say "no" to antioxidant-chelator therapy. Liver Transpl. 2005;11(11):1323-1325
26. Shamieh I, Kibort PK, Suchy FJ, Freese DK. Antioxidant therapy for neonatal iron storage disease (NISD) [abstract]. Pediatr Res. 1993;33(4):109A
27. Rand EB, Karpen SJ, Zweiner J, et al. Treatment of neonatal hemochromatosis based on alloimmune causation [abstract]. Hepatology. 2006;44(suppl 4):435A
28. Timpani G, Foti F, Nicolo A, Nicotina PA, Nicastro E, Iorio R. Is exchange transfusion a possible treatment for neonatal hemochromatosis? J Hepatol. 2007;47(5):732-735
29. Ekong U. The treatment conundrum of neonatal hemochromatosis. Pediatr Transplant. 2007;11(4):347-348
30. Carrabin N, Cordier MP, Gaucherand P. High-dose immunoglobulin during pregnancy for two patients with risk of recurrent neonatal haemochromatosis [in French]. J Gynecol Obstet Biol Re- prod (Paris). 2007;36(4):409-412
31. Venkat-Raman N, Venkata-Krishnan RV, HowarthES. Successful pregnancy outcome following maternal intravenous immunoglobulin treatment in a woman with recurrent perinatal haemochromatosis. Prenat Diagn. 2006;26(13):1256-1259