Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4597-4601

  Khanum, Shaukath Ara ^a   Khanum, Noor Fatima ^b   Shashikanth, M ^c  

^a UNIVERSITY OF MYSORE   (India)

^b Maharani's Science College for Women   (India)

^c Department of Chemistry   (India)

Author keywords

Acute toxicity; Anti inflammatory; Cyclooxygenase; Oxazolines; Ulcerogenic

Indexed keywords

2 ARYLOXYMETHYLOXAZOLINE DERIVATIVE; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; OXAZOLINE DERIVATIVE; PHENYLBUTAZONE; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; NONHUMAN; PAW EDEMA; RAT; ULCEROGENESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BODY WEIGHT; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; EDEMA; ETHANOLAMINE; MICROSOMES; MICROWAVES; MODELS, CHEMICAL; OXAZOLES; PHENYLBUTAZONE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; ULCER;

EID: 48849102172     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.029     Document Type: Article

References (32)

1. Williams M., Kowaluk E.A., and Arneric S.P. J. Med. Chem. 42 (1999) 381
2. Smith W.L., and Marnett L. J. Biochim. Biophys. Acta 1083 (1991) 1
3. Vane J.R., Bakhle Y.S., and Annu R.M. Rev. Pharmacol. Toxicol. 38 (1998) 97
4. Smith W.L., and DeWitt D.L. Adv. Immunol. 62 (1996) 167
5. Smith W.L., Garavito R.M., and DeWitt D.L. J. Biol. Chem. 271 (1996) 33157
6. Taketo M.M. J. Nat. Cancer Inst. 90 (1998) 1529
7. Morita I.M., Schindler M.K., Regier J.C., Otto T., Hori D.L., DeWitt D.L., and Smith W.L. J. Biol. Chem. 270 (1995) 10902
8. Palomer A., Perez J.J., Navea S., Llorens O., Pascual J., Garcia M.L., and Mauleon D.M. J. Med. Chem. 43 (2000) 2280
9. Palomer A., Pascual J., Cabre M., Borras L., Gonzalez G., Aparici M., Carabaza A., Cabre F., Garcia M.L., and Mauleon D. Bioorg. Med. Chem. Lett. 12 (2002) 533
10. Frump J.A. Chem. Rev. 71 (1971) 33
11. Gant T.G., and Mayers A.I. Tetrahedron 50 (1994) 2297
12. Halliwell B., Gutteridge J.M.C., Aruoma O.I., Aeschbach R., and Loliger J. J. Agric. Foodchem. 41 (1993) 1880
13. Bosc J.J., and Jarry C. Archivder Pharmazie 331 (1999) 291
14. Akyoshi A., and Suteiibunsu R.U. Chem. Abstr. 124 (1996) 317137g
15. Vorbruggen H., and Krolikiewicz K.A. Tetrahedron 49 (1993) 9353
16. Gaertner F.C., Luxenhofer R., Blechert B., Jordan R., and Essler M. J. Control Release 119 (2007) 291
17. Umekawa M., Huang W., Li B., Fujita K., Ashida H., Wang L.X., and Yamamoto K. J. Biol. Chem. 283 (2008) 4469
18. Patenaude A., Deschesnes R.G., Rousseau J.L., Petitclerc E., Lacroix J., Côté M.F., and Gaudreault C.-R. Cancer Res. 67 (2007) 2306
19. Adams; Nico, S.; Ulrich, Adv. Drug Del. Rev., 2007, 59, 1504.
20. Rasappan R., Hager M., Gissibl A., and Reiser O. Org. Lett. 8 (2006) 6099
21. Fan L., Lobkovsky E., and Ganem B. Org. Lett. 9 (2007) 2015
22. Minakata S., Morino Y., Oderaotoshi Y., and Komatsu M. Org. Lett. 8 (2006) 3335
23. Atkinson D.C., Godfrey K.E., Meek B., Saville J.F., and Stillings M.R. J. Med. Chem. 26 (1983) 1353
24. Kunsch C., Luchoomun J., Chen X.L., Dodd G.L., Karu K.S., Meng C.Q., Marino E.M., Olliff L.K., Piper J.D., Qiu F.H., Sikorski J.A., Somers P.K., Suen K.L., Thomas S., Whalen A.M., Wasserman M.A., and Sundell C.L. J. Pharmacol. Exp. Ther. 313 (2005) 492
25. Khanum S.A., Venu T.D., Shashikanth S., and Firdouse A. Bioorg. Chem. Lett. 14 (2005) 5351
26. Varma R.S., Dahiya R., and Saini R.K. Tetrahedron Lett. 38 (1997) 8819
27. 2O exchangeable)
28. +, 68), 345 (55), 228 (52), 230 (50), 212 (34), 214 (32), 172 (100), 174 (97), 156 (26), 158 (25).
29. Winter, C. A.; Risley, E. A.; Nuss, G. W. Proc. Soc. Exp. Biol. New York, 1962. 111, 544.
30. Djahanguiri B. J. Pharm. Pharmacol. 21 (1969) 541
31. Smith Q.E. J. Pharmacol. Exp. Ther. 100 (1950) 408
32. Calderano V., Parrillo C., and Grovane A. J. Pharmacol. Exp. Ther. 263 (1992) 579