Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee

Scandinavian Journal of Medicine and Science in Sports

Volumn 18, Issue 4, 2008, Pages 427-435

  Scott, A ^a   Lian, O ^b,c   Roberts, C R ^a   Cook, J L ^d   Handley, C J ^e   Bahr, R ^b   Samiric, T ^e   Ilic, M Z ^e   Parkinson, J ^e   Hart, D A ^f   Duronio, V ^a   Khan, K M ^a,g,h  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NORWEGIAN SCHOOL OF SPORT SCIENCES   (Norway)

^c Kristiansund Hospital   (Norway)

^d DEAKIN UNIVERSITY   (Australia)

^e LA TROBE UNIVERSITY   (Australia)

^f UNIVERSITY OF CALGARY   (Canada)

^g VANCOUVER COASTAL HEALTH   (Canada)

^h UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Extracellular matrix; Patellar tendon; Tendinosis; Versican

Indexed keywords

VERSICAN;

ADULT; ARTICLE; BIOPSY; CASE CONTROL STUDY; EXTRACELLULAR MATRIX; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; KNEE INJURY; MALE; METABOLISM; PATELLA LIGAMENT; PATHOLOGY; SPORT INJURY; TENDINITIS; WESTERN BLOTTING;

ADULT; ATHLETIC INJURIES; BIOPSY; BLOTTING, WESTERN; CASE-CONTROL STUDIES; EXTRACELLULAR MATRIX; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KNEE INJURIES; MALE; PATELLAR LIGAMENT; TENDINOPATHY; VERSICANS;

EID: 48849095688     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/j.1600-0838.2007.00735.x     Document Type: Article

References (50)

1. Almekinders LC, Weinhold PS, Maffulli N. Compression etiology in tendinopathy. Clin Sports Med 2003 : 22 : 703 710.
2. Archambault JM, Jelinsky SA, Lake SP, Hill AA, Glaser DL, Soslowsky LJ. Rat supraspinatus tendon expresses cartilage markers with overuse. J Orthop Res 2007 : 25 : 617 624.
3. Banes AJ, Horesovsky G, Larson C, Tsuzaki M, Judex S, Archambault J, Zernicke R, Herzog W, Kelley S, Miller L. Mechanical load stimulates expression of novel genes in vivo and in vitro in avian flexor tendon cells. Osteoarthrit Cartilage 1999 : 7 : 141 153.
4. Bernstein EF, Fisher LW, Li K, LeBaron RG, Tan EM, Uitto J. Differential expression of the versican and decorin genes in photoaged and sun-protected skin. Comparison by immunohistochemical and northern analyses. Lab Invest 1995 : 72 : 662 669.
5. Biberthaler P, Wiedemann E, Nerlich A, Kettler M, Mussack T, Deckelmann S, Mutschler W. Microcirculation associated with degenerative rotator cuff lesions. In vivo assessment with orthogonal polarization spectral imaging during arthroscopy of the shoulder. J Bone Jt Surg Am 2003 : 85-A : 475 480.
6. Bode-Lesniewska B, Dours-Zimmermann MT, Odermatt BF, Briner J, Heitz PU, Zimmermann DR. Distribution of the large aggregating proteoglycan versican in adult human tissues. J Histochem Cytochem 1996 : 44 : 303 312.
7. Boor PJ, Ferrans VJ. Ultrastructural alterations in allylamine cardiovascular toxicity. Late myocardial and vascular lesions. Am J Pathol 1985 : 121 : 39 54.
8. Cattaruzza S, Schiappacassi M, Ljungberg-Rose A, Spessotto P, Perissinotto D, Morgelin M, Mucignat MT, Colombatti A, Perris R. Distribution of PG-M/versican variants in human tissues and de novo expression of isoform V3 upon endothelial cell activation, migration, and neoangiogenesis in vitro. J Biol Chem 2002 : 277 : 47626 47635.
9. Clarkson PM, Kroll W, McBride TC. Maximal isometric strength and fiber type composition in power and endurance athletes. Eur J Appl Physiol Occup Physiol 1980 : 44 : 35 42.
10. Cook JL, Khan KM, Kiss ZS, Purdam CR, Griffiths L. Prospective imaging study of asymptomatic patellar tendinopathy in elite junior basketball players. J Ultrasound Med 2000 : 19 : 473 479.
11. Corps AN, Robinson AH, Movin T, Costa ML, Hazleman BL, Riley GP. Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy. Rheumatology (Oxford) 2006 : 45 : 291 294.
12. Darby I, Skalli O, Gabbiani G. Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 1990 : 63 : 21 29.
13. Evanko SP, Johnson PY, Braun KR, Underhill CB, Dudhia J, Wight TN. Platelet-derived growth factor stimulates the formation of versican-hyaluronan aggregates and pericellular matrix expansion in arterial smooth muscle cells. Arch Biochem Biophys 2001 : 394 : 29 38.
14. Evanko SP, Raines EW, Ross R, Gold LI, Wight TN. Proteoglycan distribution in lesions of atherosclerosis depends on lesion severity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-beta. Am J Pathol 1998 : 152 : 533 546.
15. Fenwick S, Harrall R, Hackney R, Bord S, Horner A, Hazleman B, Riley G. Endochondral ossification in Achilles and patella tendinopathy. Rheumatology (Oxford) 2002 : 41 : 474 476.
16. Fukuda H, Hamada K, Yamanaka K. Pathology and pathogenesis of bursal-side rotator cuff tears viewed from en bloc histologic sections. Clin Orthop Relat Res 1990 : 254 : 75 80.
17. Grande-Allen KJ, Calabro A, Gupta V, Wight TN, Hascall VC, Vesely I. Glycosaminoglycans and proteoglycans in normal mitral valve leaflets and chordae: association with regions of tensile and compressive loading. Glycobiology 2004 : 14 : 621 633.
18. Hamilton B, Purdam C. Patellar tendinosis as an adaptive process: a new hypothesis. Br J Sports Med 2004 : 38 : 758 761.
19. Hazleman B, Riley G, Speed CA. Soft tissue rheumatology. Oxford: Oxford University Press, 2004.
20. Isogai Z, Shinomura T, Yamakawa N, Takeuchi J, Tsuji T, Heinegard D, Kimata K. 2B1 antigen characteristically expressed on extracellular matrices of human malignant tumors is a large chondroitin sulfate proteoglycan, PG-M/versican. Cancer Res 1996 : 56 : 3902 3908.
21. Khan KM, Bonar F, Desmond PM, Cook JL, Young DA, Visentini PJ, Fehrmann MW, Kiss ZS, O'Brien PA, Harcourt PR, Dowling RJ, O'Sullivan RM, Crichton KJ, Tress BM, Wark JD. Patellar tendinosis (jumper's knee): findings at histopathologic examination, US, and MR imaging. Victorian Institute of Sport Tendon Study Group. Radiology 1996 : 200 : 821 827.
22. Khan KM, Cook JL, Bonar F, Harcourt P, Astrom M. Histopathology of common tendinopathies. Update and implications for clinical management. Sports Med 1999 : 27 : 393 408.
23. Kinsella MG, Bressler SL, Wight TN. The regulated synthesis of versican, decorin, and biglycan: extracellular matrix proteoglycans that influence cellular phenotype. Crit Rev Eukaryot Gene Expr 2004 : 14 : 203 234.
24. Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev 2004 : 84 : 649 698.
25. Kristoffersen M, Ohberg L, Johnston C, Alfredson H. Neovascularisation in chronic tendon injuries detected with colour Doppler ultrasound in horse and man: implications for research and treatment. Knee Surg Sports Traumatol Arthrosc 2005 : 13 : 505 508.
26. Landberg G, Tan EM, Roos G. Flow cytometric multiparameter analysis of proliferating cell nuclear antigen/cyclin and Ki-67 antigen: a new view of the cell cycle. Exp Cell Res 1990 : 187 : 111 118.
27. Lo IK, Boorman R, Marchuk L, Hollinshead R, Hart DA, Frank CB. Matrix molecule mRNA levels in the bursa and rotator cuff of patients with full-thickness rotator cuff tears. Arthroscopy 2005 : 21 : 645 651.
28. Maffulli N, Khan KM, Puddu G. Overuse tendon conditions: time to change a confusing terminology. Arthroscopy 1998 : 14 : 840 843.
29. Maffulli N, Reaper J, Ewen SW, Waterston SW, Barrass V. Chondral metaplasia in calcific insertional tendinopathy of the Achilles tendon. Clin J Sports Med 2006 : 16 : 329 334.
30. Malaviya P, Butler DL, Boivin GP, Smith FN, Barry FP, Murphy JM, Vogel KG. An in vivo model for load-modulated remodeling in the rabbit flexor tendon. J Orthop Res 2000 : 18 : 116 125.
31. Mao JJ, Rahemtulla F, Scott PG. Proteoglycan expression in the rat temporomandibular joint in response to unilateral bite raise. J Dent Res 1998 : 77 : 1520 1528.
32. Matsumoto K, Kamiya N, Suwan K, Atsumi F, Shimizu K, Shinomura T, Yamada Y, Kimata K, Watanabe H. Identification and characterization of versican/PG-M aggregates in cartilage. J Biol Chem 2006 : 281 : 18257 18263.
33. Milz S, Benjamin M, Putz R. Molecular parameters indicating adaptation to mechanical stress in fibrous connective tissue. Adv Anat Embryol Cell Biol 2005 : 178 : 1 71.
34. Nikitovic D, Zafiropoulos A, Katonis P, Tsatsakis A, Theocharis AD, Karamanos NK, Tzanakakis GN. Transforming growth factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, hyaluronan synthase-2 and synthesis of hyaluronan in malignant osteosarcoma cells. IUBMB Life 2006 : 58 : 47 53.
35. Petersen W, Hohmann G, Pufe T, Tsokos M, Zantop T, Paulsen F, Tillmann B. Structure of the human tibialis posterior tendon. Arch Orthop Trauma Surg 2004 : 124 : 237 242.
36. Provenzano PP, Alejandro-Osorio AL, Valhmu WB, Jensen KT, Vanderby R Jr. Intrinsic fibroblast-mediated remodeling of damaged collagenous matrices in vivo. Matrix Biol 2005 : 23 : 543 555.
37. Rahmani M, Wong BW, Ang L, Cheung CC, Carthy JM, Walinski H, McManus BM. Versican: signaling to transcriptional control pathways. Can J Physiol Pharmacol 2006 : 84 : 77 92.
38. Riley G. The pathogenesis of tendinopathy. A molecular perspective. Rheumatology (Oxford) 2004 : 43 : 131 142.
39. Riley GP. Gene expression and matrix turnover in overused and damaged tendons. Scand J Med Sci Sports 2005 : 15 : 241 251.
40. Ritty TM, Roth R, Heuser JE. Tendon cell array isolation reveals a previously unknown fibrillin-2-containing macromolecular assembly. Structure 2003 : 11 : 1179 1188.
41. Robbins JR, Evanko SP, Vogel KG. Mechanical loading and TGF-beta regulate proteoglycan synthesis in tendon. Arch Biochem Biophys 1997 : 342 : 203 211.
42. Roberts CR. Is asthma a fibrotic disease? Chest 1995 : 107 : 111S 117S.
43. Samiric T, Ilic MZ, Handley CJ. Characterisation of proteoglycans and their catabolic products in tendon and explant cultures of tendon. Matrix Biol 2004 : 23 : 127 140.
44. Schmitt-Graff A, Desmouliere A, Gabbiani G. Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity. Virchows Arch 1994 : 425 : 3 24.
45. Skalli O, Pelte MF, Peclet MC, Gabbiani G, Gugliotta P, Bussolati G, Ravazzola M, Orci L. Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes. J Histochem Cytochem 1989 : 37 : 315 321.
46. Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G. A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986 : 103 : 2787 2796.
47. Visentini PJ, Khan KM, Cook JL, Kiss ZS, Harcourt PR, Wark JD. The VISA score: an index of severity of symptoms in patients with jumper's knee (patellar tendinosis). Victorian Institute of Sport Tendon Study Group. J Sci Med Sport/Sports Med (Australia) 1998 : 1 : 22 28.
48. Woo SL, Ritter MA, Amiel D, Sanders TM, Gomez MA, Kuei SC, Garfin SR, Akeson WH. The biomechanical and biochemical properties of swine tendons - long term effects of exercise on the digital extensors. Connect Tissue Res 1980 : 7 : 177 183.
49. Yoon JH, Halper J. Tendon proteoglycans: biochemistry and function. J Musculoskelet Neuronal Interact 2005 : 5 : 22 34.
50. Young MA, Cook JL, Purdam CR, Kiss ZS, Alfredson H. Eccentric decline squat protocol offers superior results at 12 months compared with traditional eccentric protocol for patellar tendinopathy in volleyball players. Br J Sports Med 2005 : 39 : 102 105.