Characterisation of a novel growth hormone variant comprising a thioether link between Cys182 and Cys189

ChemMedChem

Volumn 2, Issue 8, 2007, Pages 1181-1189

  Datola, Antonio ^a   Richert, Sophie ^a   Bierau, Horst ^a   Agugiaro, David ^a   Izzo, Anna ^a   Rossi, Mara ^a   Cregut, David ^b   Diemer, Hélène ^c   Schaeffer, Christine ^c   Van Dorsselaer, Alain ^c   Giartosio, Carlo Emanuele ^a   Jone, Carl ^a  

^a Industria Farmaceutica Serono   (Italy)

^b MERCK SERONO S A   (Switzerland)

^c INSTITUT DE RECHERCHES SUBATOMIQUES   (France)

Author keywords

Bioactivity; Growth hormone; Immunogenicity; Post translational modification; Protein structure; Thioether

Indexed keywords

CYSTEINE; GROWTH HORMONE; RECOMBINANT PROTEIN; SULFIDE;

ARTICLE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METABOLISM; PEPTIDE MAPPING;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; GROWTH HORMONE; HUMANS; PEPTIDE MAPPING; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFIDES;

EID: 48849090913     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200700042     Document Type: Article

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