GM1 ganglioside contributes to retain the neuronal conduction and neuronal excitability in visceral and baroreceptor afferents

Journal of Neurochemistry

Volumn 106, Issue 4, 2008, Pages 1637-1645

  Qiao, Guo Fen ^a   Cheng, Zhi Feng ^a   Huo, Rong ^a   Sui, Xiao Hong ^a   Lu, Yan Jie ^a   Li, Bai Yan ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Ganglioside; Myelination; Na+ channel; Neuronal excitability; Visceral afferent

Indexed keywords

CARISOPRODOL; CHOLERA TOXIN B SUBUNIT; GANGLIOSIDE GM1; SODIUM CHANNEL; TETRODOTOXIN;

ACTION POTENTIAL; AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; FLUORESCENCE; MALE; MYELINATED NERVE; NERVE CELL EXCITABILITY; NERVE CONDUCTION; NEUROMODULATION; NODOSE GANGLION; NONHUMAN; PRESSORECEPTOR; PRIORITY JOURNAL; RAT; SENSORY NERVE; SPIKE WAVE;

ACTION POTENTIALS; ANIMALS; CELLS, CULTURED; CHOLERA TOXIN; G(M1) GANGLIOSIDE; MALE; NEURAL CONDUCTION; NEURONS; NODOSE GANGLION; PRESSORECEPTORS; RATS; RATS, SPRAGUE-DAWLEY; TETRODOTOXIN; VISCERAL AFFERENTS;

EID: 48749127781     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05515.x     Document Type: Article

References (23)

1. Argentino C., Sacchetti M. L., Toni D. et al. (1989) GM1 ganglioside therapy in acute ischemic stroke. Stroke 20, 1143 1149.
2. Crain S. M. Shen K. F. (1992) After GM1 ganglioside treatment of sensory neurons naloxone paradoxically prolongs the action potential but still antagonizes opioid inhibition. J. Pharmacol. Exp. Ther. 260, 182 186.
3. Doyle M. W., Bailey T. W., Jin Y. H. et al. (2004) Strategies for identification in nucleus tractus solitarius slices. J. Neurosci. Methods 137, 37 48.
4. Duchemin A. M., Ren Q., Neff N. H. et al. (2008) GM1-induced activation of phophatidylinositol 3-kinase: involvement of Trk receptors. J. Neurochem. 104, 1466 1477.
5. Geisler F. H., Dorsey F. C. Coleman W. P. (1991) Recovery of motor function after spinal cord injury - a randomized placebo-controlled trail with GM1 ganglioside. New Engl. J. Med. 324, 1829 1838.
6. Hakomori S. (1990) Bifunctional role of glycosphingolipids, Modulators for transmembrane signaling and mediators for cellular interactions. J. Biol. Chem. 265, 18713 18716.
7. Hughes R. A. Cornblath D. R. (2005) Guillain-Barre syndrome. Lancet Neurol. 336, 1653 1666.
8. Ledeen R. W. Wu G. (1992) Ganglioside function in the neuron. Trends Glycosci. Glycotech. 4, 174 187.
9. Li B. Y. Schild J. H. (2002) Patch clamp electrophysiology in nodose ganglia of adult rat. J. Neurosci. Methods 83, 886 897.
10. + ion channels in adult rat aortic baroreceptor neurons with myelinated and unmyelinated afferent fibers. FASEB J. 20, A775.
11. 2 via cyclic AMP-dependent pathway in C-type nodose neurons of adult rats. Biochem. Biophys. Res. Commun. 355, 1064 1068.
12. Li B. Y. Schild J. H. (2007b) Electrophysiological and pharmacological validation of vagal afferent fiber type of neurons enzymatically isolated from rat nodose ganglia. J. Neurosci. Methods 164, 75 85.
13. Li B. Y., Feng B., Tsu H. Y. et al. (2007) Unmyelinated visceral afferents exhibit frequency dependent action potential broadening while myelinated visceral afferents do not. Neurosci. Lett. 421, 62 66.
14. Milani D., Minozzi M. C., Petrelli L. et al. (1992) Interaction of ganglioside GM1 with the B subunit of cholera toxin modulates intracellular free calcium in sensory neurons. J. Neurosci. Res. 33, 466 475.
15. Qiao G. F., Li S., Yang B. F. et al. (2007) Inhibitory effects of artemisinin on voltage-gated ion channels in intact nodose ganglion neurons of adult rats. Basic Clin. Pharmacol. Toxicol. 100, 217 224.
16. Schengrund C. L. (1990) The role(s) of gangliosides in neural differentiation and repair: a perspective. Brain Res. Bull. 24, 131 141.
17. Schneider J. S., Pope A., Simpson K. et al. (1992) Recovery from experimental Parkinsonism in primates with GM1 ganglioside treatment. Science 256, 843 846.
18. Shen K. F., Crain S. M. Ledeen R. W. (1991) Brief treatment of sensory ganglion neurons with GM1 ganglioside enhances the efficacy of opioid excitatory effects on action potential. Brain Res. 559, 130 138.
19. Susuki K., Rasband M. N., Tohyama K. et al. (2007a) Anti-GM1 antibodies cause complement-mediated disruption of sodium channel clusters in peripheral motor nerve fibers. J. Neurosci. 27, 3956 3967.
20. Susuki K., Baba H., Tohyama K. et al. (2007b) Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated never fibers. Glia 55, 746 757.
21. + currents in rat single myelinated nerve fibers. Internal Med. 39, 123 127.
22. Watanabe S., Shimazu K. Hosokawa T. (1993) A case of paraneoplastic autonomic and sensorimotor neuropathy with dysfunction in the afferent limb of baroreflex arc. Rinsho Shinleigaku 33, 646 651.
23. Xiao W. H., Yu A. L. Sorkin L. S. (1997) Electrophysiological characteristics of primary afferent fibers after systemic administration of anti-GD2 ganglioside antibody. Pain 69, 145 151.