Enhancing effect of HT008-1 on cognitive function and quality of life in cognitively declined healthy adults: A randomized, double-blind, placebo-controlled, trial

Pharmacology Biochemistry and Behavior

Volumn 90, Issue 4, 2008, Pages 517-524

  Kim, Jongwoo ^a   Chung, Sun Yong ^a   Park, Sojeong ^a   Park, Jong Hoon ^a   Byun, Soonim ^a   Hwang, Manki ^b   Oh, Dal Seok ^b   Choi, Hyungsuk ^b   Kim, Mi Yeon ^b   Bu, Youngmin ^b   Doré, Sylvain ^c   Whang, Wei wan ^a   Kim, Hocheol ^b  

^a Kyung Hee University College of Medicine   (South Korea)

^b Kyung Hee University   (South Korea)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clinical trial; Cognition; Ginseng; Herb; HT008 1; Memory; Quality of life

Indexed keywords

ACANTHOPANAX SENTICOSUS EXTRACT; ANGELICA SINENSIS EXTRACT; BAICALEIN; BAICALIN; CHLOROGENIC ACID; ELEUTHROSIDE B; ELEUTHROSIDE E; GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RG 1; HERBACEOUS AGENT; HT 008 1; LIGUSTILIDE; PLACEBO; SCUTELLARIA BAICALENSIS EXTRACT; WOGONIN; WOGONOSIDE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; COGNITION; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DERMATITIS; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; ECZEMA; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY; PAIN; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; VOMITING; WECHSLER MEMORY SCALE;

AGED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COGNITION; COGNITION DISORDERS; DOUBLE-BLIND METHOD; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; NOOTROPIC AGENTS; PLANT EXTRACTS; PSYCHIATRIC STATUS RATING SCALES; QUALITY OF LIFE; WECHSLER SCALES;

PANAX GINSENG;

EID: 48749119023     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.03.033     Document Type: Article

References (42)

1. Arushanian E.B., Baida O.A., Mastiagin S.S., Popova A.P., and Shikina I.B. Effect of eleutherococcus on short-term memory and visual perception in healthy humans. Eksp Klin Farmakol 66 (2003) 10-13
2. Bu Y., Jin Z.H., Park S.Y., Baek S., Rho S., Ha N., et al. Siberian ginseng reduces infarct volume in transient focal cerebral ischaemia in Sprague-Dawley rats. Phytother Res 19 (2005) 167-169
3. Cardinal B.J., and Engels H.J. Ginseng does not enhance psychological well-being in healthy, young adults: results of a double-blind, placebo-controlled, randomized clinical trial. J Am Diet Assoc 101 (2001) 655-660
4. Chey J., Na D.R., Park S., Park E., and Lee S. Effects of education in dementia assessment: evidence from standardizing the Korean-Dementia Rating Scale. Clin Neuropsychol 13 (1999) 293-302
5. D'Angelo L., Grimaldi R., Caravaggi M., Marcoli M., Perucca E., Lecchini S., et al. A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol 16 (1986) 15-22
6. Folstein M.F., Folstein S.E., and McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12 (1975) 189-198
7. Hartley D.E., Elsabagh S., and File S.E. Gincosan (a combination of Ginkgo biloba and Panax ginseng): the effects on mood and cognition of 6 and 12 weeks' treatment in post-menopausal women. Nutr Neurosci 7 (2004) 325-333
8. Hsieh M.T., Lin Y.T., Lin Y.H., and Wu C.R. Radix Angelica sinensis extracts ameliorate scopolamine- and cycloheximide-induced amnesia, but not p-chloroamphetamine-induced amnesia in rats. Am J Chin Med 28 (2000) 263-272
9. Hsieh M.T., Tsai F.H., Lin Y.C., Wang W.H., and Wu C.R. Effects of ferulic acid on the impairment of inhibitory avoidance performance in rats. Planta Med. 68 (2002) 754-756
10. Iverson G.L. Interpreting change on the WAIS-III/WMS-III in clinical samples. Arch Clin Neuropsychol 16 (2001) 183-191
11. Kanowski S., Herrmann W.M., Stephan K., Wierich W., and Horr R. Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 29 (1996) 47-56
12. Kennedy D.O., Scholey A.B., and Wesnes K.A. The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers. Psychopharmacology (Berl) 151 (2000) 416-423
13. Kennedy D.O., Scholey A.B., and Wesnes K.A. Differential, dose dependent changes in cognitive performance following acute administration of a Ginkgo biloba/Panax ginseng combination to healthy young volunteers. Nutr Neurosci 4 (2001) 399-412
14. Kennedy D.O., Scholey A.B., and Wesnes K.A. Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults. Physiol Behav 75 (2002) 739-751
15. Kim H. Textbook of herbal pharmacology (2001), Jipmoondang, Seoul
16. Kim Y.O., Leem K., Park J., Lee P., Ahn D.K., Lee B.C., et al. Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia. J Ethnopharmacol 77 (2001) 183-188
17. Kim D.H., Jeon S.J., Son K.H., Jung J.W., Lee S., Yoon B.H., et al. Effect of the flavonoid, oroxylin A, on transient cerebral hypoperfusion-induced memory impairment in mice. Pharmacol Biochem Behav. 85 (2006) 658-668
18. Kim D.H., Jeon S.J., Son K.H., Jung J.W., Lee S., Yoon B.H., et al. The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice. Neurobiol Learn Mem 87 (2007) 536-546
19. Kim Y.T., Yi Y.J., Kim M.Y., Bu Y., Jin Z.H., Choi H., et al. Neuroprotection and enhancement of spatial memory by herbal mixture HT008-1 in a rat global brain ischemia model. Am J Chin Med 36 (2008) 287-299
20. Kreijkamp-Kaspers S., Kok L., Grobbee D.E., de Haan E.H., Aleman A., Lampe J.W., et al. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA 292 (2004) 65-74
21. Kurimoto H., Nishijo H., Uwano T., Yamaguchi H., Zhong Y.M., Kawanishi K., et al. Effects of nonsaponin fraction of red ginseng on learning deficits in aged rats. Physiol Behav 82 (2004) 345-355
22. Le Bars P.L., Katz M.M., Berman N., Itil T.M., Freedman A.M., and Schatzberg A.F. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. JAMA 278 (1997) 1327-1332
23. Liu C., Wu J., Gu J., Xiong Z., Wang F., Wang J., et al. Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats. Pharmacol Biochem Behav 86 (2007) 423-430
24. McDowell B.D., Bayless J.D., Moser D.J., Meyers J.E., and Paulsen J.S. Concordance between the CVLT and the WMS-III word lists test. Arch Clin Neuropsychol 19 (2004) 319-324
25. Min S.K., Kim K.I., Lee C.I., Jung Y.C., Suh S.Y., and Kim D.K. Development of the Korean versions of WHO quality of life scale and WHOQOL-BREF. Qual Life Res 11 (2002) 593-600
26. Nishijo H., Uwano T., Zhong Y.M., and Ono T. Proof of the mysterious efficacy of ginseng: basic and clinical trials: effects of red ginseng on learning and memory deficits in an animal model of amnesia. J Pharmacol Sci 95 (2004) 145-152
27. Nitta H., Matsumoto K., Shimizu M., Ni X.H., and Watanabe H. Panax ginseng extract improves the performance of aged Fischer 344 rats in radial maze task but not in operant brightness discrimination task. Biol Pharm Bull 18 (1995) 1286-1288
28. Park J.H., and Kwon Y.C. Korean Version of Mini Mental State Examination (MMSE-K) Part I: development of the test for the elderly. J Korean Neuropsychiatr Assoc 28 (1989) 125-135
29. Pershina O.V., Skurikhin E.G., and Suslov N.I. The influence of natural preparations on long-term conflict situation consequences in rats with different cognitive abilities. Eksp Klin Farmakol 68 (2005) 16-18
30. Persson J., Bringlov E., Nilsson L.G., and Nyberg L. The memory-enhancing effects of Ginseng and Ginkgo biloba in healthy volunteers. Psychopharmacology (Berl) 172 (2004) 430-434
31. Rai G.S., Shovlin C., and Wesnes K.A. A double-blind, placebo controlled study of Ginkgo biloba extract ('tanakan') in elderly outpatients with mild to moderate memory impairment. Curr Med Res Opin 12 (1991) 350-355
32. Reay J.L., Kennedy D.O., and Scholey A.B. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. J Psychopharmacol 20 (2006) 771-781
33. Seo J., Woo S.Y., Kim Y.T., Kim M.Y., Park Y.M., Jin Z.H., et al. Enhancing effect of multiherb extracts HT008-1 on memory and cognitive function. Korean J Herbology 22 (2007) 51-58
34. Shang Y.Z., Gong M.Y., Zhou X.X., Li S.T., and Wang B.Y. Improving effects of SSF on memory deficits and pathological changes of neural and immunological systems in senescent mice. Acta Pharmacol Sin 22 (2001) 1078-1083
35. Shang Y.Z., Miao H., Cheng J.J., and Qi J.M. Effects of amelioration of total flavonoids from stems and leaves of Scutellaria baicalensis Georgi on cognitive deficits, neuronal damage and free radicals disorder induced by cerebral ischemia in rats. Biol Pharm Bull 29 (2006) 805-810
36. Testa M.A., and Simonson D.C. Assessment of quality-of-life outcomes. N Engl J Med 334 (1996) 835-840
37. Tulsky D.S., and Ledbetter M.F. Updating to the WAIS-III and WMS-III: Conditions for research and clinical practice. Psychol Assess 12 (2000) 253-262
38. Wechsler D. WMS-III administration and scoring manual (1997), The Psychological Coporation, San Antonio, TX
39. World Medical Association. Recommendations guiding physicians in biomedical research involving human subjects. JAMA 277 (1997) 925-926
40. Yamaguchi Y., Higashi M., and Kobayashi H. Effects of ginsenosides on impaired performance caused by scopolamine in rats. Eur J Pharmacol 312 (1996) 149-151
41. Zappala G., Measso G., Cavarzeran F., Grigoletto F., Lebowitz B., Pirozzolo F., et al. Aging and memory: corrections for age, sex and education for three widely used memory tests. Ital J Neurol Sci 16 (1995) 177-184
42. Zhong Y.M., Nishijo H., Uwano T., Tamura R., Kawanishi K., and Ono T. Red ginseng ameliorated place navigation deficits in young rats with hippocampal lesions and aged rats. Physiol Behav 69 (2000) 511-525