Positive association between HIV RNA and IL-6 in the genital tract of Rwandan women

AIDS Research and Human Retroviruses

Volumn 24, Issue 7, 2008, Pages 973-976

  Spear, Gregory T ^a   Zariffard, M Reza ^a   Chen, Hua Y ^b   Anzinger, Joshua J ^a   Anastos, Kathryn ^c   Rusine, John ^d   Gatabazi, John ^d   French, Audrey L ^a,e   Cohen, Mardge ^a,e   Landay, Alan L ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d Ministry of Health   (Rwanda)

^e Jr Hospital of Cook County   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; INTERLEUKIN 6; VIRUS RNA;

ADULT; ARTICLE; CORRELATION ANALYSIS; CYTOMETRY; FEMALE; FEMALE GENITAL SYSTEM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MAJOR CLINICAL STUDY; MULTIPLE REGRESSION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RWANDA; UNIVARIATE ANALYSIS; UTERINE CERVIX CYTOLOGY; VAGINAL LAVAGE; VIRUS EXPRESSION; VIRUS LOAD;

ADULT; FEMALE; FLOW CYTOMETRY; GENITAL DISEASES, FEMALE; HIV; HIV INFECTIONS; HUMANS; INTERLEUKIN-6; MIDDLE AGED; POLYMERASE CHAIN REACTION; RNA, VIRAL; RWANDA; VAGINAL DOUCHING; VIRAL LOAD;

EID: 48749115479     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2008.0004     Document Type: Article

References (18)

1. Kovacs A, Wasserman SS, Burns D, et al.: Determinants of HIV-1 shedding in the genital tract of women. Lancet 2001;358:1593-1601.
2. Wawer MJ, Gray RH, Sewankambo NK, et al.: Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis 2005;191:1403-1409.
3. Quinn TC, Wawer MJ, Sewankambo N, et al.: Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med 2000;342:921-929.
4. Operskalski EA, Stram DO, Busch MP, et al.: Role of viral load in heterosexual transmission of human immunodeficiency virus type 1 by blood transfusion recipients. Transfusion Safety Study Group. Am J Epidemiol 1997;146:655-661.
5. Sha BE, Zariffard MR, Wang QJ, et al.: Female genital-tract HIV load correlates inversely with Lactobacillus species but positively with bacterial vaginosis and Mycoplasma hominis. J Infect Dis 2005;191:25-32.
6. Ghys PD, Fransen K, Diallo MO, et al.: The associations between cervicovaginal HIV shedding, sexually transmitted diseases and immunosuppression in female sex workers in Abidjan, Cote d'Ivoire. AIDS 1997;11:F85-93.
7. Lawn SD, Subbarao S, Wright TC Jr, et al.: Correlation between human immunodeficiency virus type 1 RNA levels in the female genital tract and immune activation associated with ulceration of the cervix. J Infect Dis 2000;181:1950-1956.
8. McClelland RS, Wang CC, Mandaliya K, et al.: Treatment of cervicitis is associated with decreased cervical shedding of HIV-1. AIDS 2001;15:105-110.
9. Wang CC, McClelland RS, Reilly M, et al.: The effect of treatment of vaginal infections on shedding of human immunodeficiency virus type 1. J Infect Dis 2001;183:1017-1022.
10. Nugent RP, Krohn MA, and Hillier SL: Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 1991;29:297-301.
11. Lisi PJ, Dondero RS, Kwiatkoski D, Spence MR, Rein MF, and Alderete JF: Monoclonal-antibody-based enzyme-linked immunosorbent assay for Trichomonas vaginalis. J Clin Microbiol 1988;26:1684-1686.
12. Sha BE, Chen HY, Wang QJ, Zariffard MR, Cohen MH, and Spear GT: Utility of Amsel criteria, Nugent score, and quantitative PCR for Gardnerella vaginalis, Mycoplasma hominis, and Lactobacillus spp. for diagnosis of bacterial vaginosis in human immunodeficiency virus-infected women. J Clin Microbiol 2005;43:4607-4612.
13. Osborn L, Kunkel S, and Nabel GJ: Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci USA 1989;86:2336-2340.
14. Poli G, Bressler P, Kinter A, et al.: Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms. J Exp Med 1990;172:151-158.
15. Zara F, Nappi RE, Brerra R, Migliavacca R, Maserati R, and Spinillo A: Markers of local immunity in cervico-vaginal secretions of HIV infected women: Implications for HIV shedding. Sex Transm Infect 2004;80:108-112.
16. Wang Y, Abel K, Lantz K, Krieg AM, McChesney MB, and Miller CJ: The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques. J Virol 2005;79:14355-14370.
17. Fichorova RN, Bajpai M, Chandra N, et al.: Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives. Biol Reprod 2004;71:761-769.
18. Al-Harthi L, Kovacs A, Coombs RW, et al.: A menstrual cycle pattern for cytokine levels exists in HIV-positive women: Implication for HIV vaginal and plasma shedding. AIDS 2001;15:1535-1543.