Reverse mode of Na+Ca2+ exchange inhibitor, KB-r7943 attenuates tubular epithelial cell apoptosis induced by contrast media

Chinese Journal of Emergency Medicine

Volumn 17, Issue 7, 2008, Pages 713-716

  Yang, Ding Ping ^a   Jia, Ru Han ^a   Ding, Guo Hua ^a   Yang, Ding Wei ^a   Xiong, Xiao Ling ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Cell Apoptosis; Contrast Media; Na+ Ca2+ exchanger inhibitor

Indexed keywords

EID: 48749114939     PISSN: 16710282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Cox CD, Tsikouris JP. Preventing contrast nephropathy: What is the best strategy? A review of the literature[J]. J Clin pharmacol, 2004, 44(4): 327-337.
2. Esnault VL. Radiocontrast media-induced nephrotoxicity in patients with renal failure: Rationale for a new double-blind, prospective, randomized trial testing calcium channel antagonists[J]. Nephrol Dial Transplant, 2002, 17(8):1362-1364.
3. Zager RA, Johnson AC, Hanson SY. Radiographic contrast media-induced tubular injury: Evaluation of oxidant stress and plasma membrane integrity[J]. Kidney Int, 2003, 64(1):128-139.
4. 2+ exchange inhibitors in attenuating ischemia-reperfusion injury[J]. Can J Cardiol, 2005, 21(6):509-516.
5. 2+ exchanger, on stunned myocardium in anesthetized dogs[J]. J Anesth, 2005, 19(2):124-130.
6. Chinese source.
7. Chinese source.
8. Solomon R. The role of osmolality in the incidence of contrast-induced nephroropathy: a systematic trview of angiographic contrast media in high-risk patients[J]. Kidney Int, 2005, 68(5):2256-2263.
9. Wang YX, Jia YF, Chen KM, et al. Radiographic contrast media induced nephropathy: Experimental observations and the protective effect of calcium channel blockers[J]. Br J Radiol, 2001, 74(888):1103-1108.
10. 2+ exchanger isoforms NCX1, NCX2, and NCX3 in rat[J]. Am J Physiol, 1997, 272(4):1250-1261.
11. 2+ exchange inhibitor, KD-R7943, shows renal protective effects in rats with ischemic acute renal failure[J]. J Pharmarol Exp Ther, 2001, 296(2):412-419.
12. 2+ exchange inhibitor, SEA0400, improves ischemia/reperfusion-induced renal injury[J]. Eur J Pharmacol, 2003, 478(2):187-198.
13. Tepel M, Van der Giet M, Schwarzfeld C, et al. Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine[J]. N Engl J Med, 2000, 343(3):180-184.