Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4529-4532

  Enomoto, Hiroshi ^a   Morikawa, Yuko ^a   Miyake, Yurika ^a   Tsuji, Fumio ^a   Mizuchi, Maki ^a   Suhara, Hiroshi ^a   Fujimura, Ken ichi ^a   Horiuchi, Masato ^a   Ban, Masakazu ^a  

^a SANTEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Epoxide hydrolase; LTA4 hydrolase; LTA4 hydrolase inhibitor; N mercaptoacyl l proline; N mercaptoacylthiazolidine 4 carboxylic acid

Indexed keywords

CAPTOPRIL; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; LEUKOTRIENE A4 HYDROLASE;

ARTICLE; DRUG SCREENING; DRUG SYNTHESIS;

ANIMALS; CARBOXYLIC ACIDS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; EPOXIDE HYDROLASES; HUMANS; INHIBITORY CONCENTRATION 50; LEUKOTRIENE A4; MODELS, CHEMICAL; PROLINE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; THIAZOLIDINES;

EID: 48749111581     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.043     Document Type: Article

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