Overexpression of human truncated peroxisome proliferator-activated receptor α induces apoptosis in HL-1 cardiomyocytes

Cardiovascular Research

Volumn 79, Issue 3, 2008, Pages 458-463

  Beaumont, Javier ^a   Arias, Teresa ^a   Ravassa, Susana ^a   Díez, Javier ^a,b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Apoptosis; Cardiomyocytes; Truncated PPAR

Indexed keywords

CASPASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVATION; GENETIC TRANSFECTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL DEATH; CELL LINE; CREB-BINDING PROTEIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYTOCHROMES C; DNA FRAGMENTATION; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MYOCYTES, CARDIAC; PHOSPHATIDYLSERINES; PPAR ALPHA; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSFECTION; UP-REGULATION;

EID: 48749102394     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn106     Document Type: Article

References (22)

1. Li Z, Bing OH, Long X, Robinson KG, Lakatta EG. Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat. Am J Physiol 1997;272:H2313-H2319.
2. Goikoetxea MJ, Beaumont J, Gonzalez A, Lopez B, Querejeta R, Larman M et al. Altered cardiac expression of peroxisome proliferator-activated receptor-isoforms in patients with hypertensive heart disease. Cardiovasc Res 2006;69:899-907.
3. Ravassa S, Gonzalez A, Lopez B, Beaumont J, Querejeta R, Larman et al. Upregulation of myocardial Annexin A5 in hypertensive heart disease: association with systolic dysfunction. Eur Heart J 2007;28:2785- 2791.
4. Goikoetxea MJ, Beaumont J, Diez J. Peroxisome proliferator-activated receptor alpha and hypertensive heart disease. Drugs 2004;64:9-18.
5. van Bilsen M, van der Vusse GJ, Gilde AJ, Lindhout M, van der Lee KA. Peroxisome proliferator-activated receptors: lipid binding proteins controling gene expression. Mol Cell Biochem 2002;239:131-138.
6. Gervois P, Torra IP, Chinetti G, Grotzinger T, Dubois G, Fruchart JC et al. A truncated human peroxisome proliferator-activated receptor alpha splice variant with dominant negative activity. Mol Endocrinol 1999;13:1535-1549.
7. Gilde AJ, Van Bilsen M. Peroxisome proliferator-activated receptors (PPARS). regulators of gene expression in heart and skeletal muscle. Acta Physiol Scand 2003;178:425-434.
8. Tokudome T, Horio T, Fukunaga M, Okumura H, Hino J, Mori K et al. Ventricular nonmyocytes inhibit doxorubicin-induced myocyte apoptosis: involvement of endogenous endothelin-1 as a paracrine factor. Endocrinology 2004;145:2458-2466.
9. Mehrhof FB, Muller FU, Bergmann MW, Li P, Wang Y, Schmitz W et al. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation 2001;104:2088-2094.
10. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. Biotechnology 1992;24:104-108.
11. Smiley ST, Reers M, Mottola-Hartshorn C, Lin M, Chen A, Smith TW et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci USA 1991;88:3671-3675.
12. Chandrasekar B, Vemula K, Surabhi RM, Li-Weber M, Owen-Schaub LB, Jensen LE et al. Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death. J Biol Chem 2004;279:20221-20233.
13. Huerta S, Goulet EJ, Huerta-Yepez S, Livingston EH. Screening and detection of apoptosis. J Surg Res 2007;139:143-156.
14. Frankfurt OS, Robb JA, Sugarbaker EV, Villa L. Monoclonal antibody to single-stranded DNA is a specific and sensitive cellular marker of apoptosis. Exp Cell Res 1996;226:387-397.
15. Nakagawa M, Tsujimoto N, Nakagawa H et al. Association of HSPB2, a member of the small heat shock protein family, with mitochondria. Exp Cell Res 2001;271:161-168.
16. Fortuño MA, Gonzalez A, Ravassa S, Lopez B, Diez J. Clinical implications of apoptosis in hypertensive heart disease. Am J Physiol Heart Circ Physiol 2003;284:H1495-H1506.
17. González A, Fortuño MA, Querejeta R, Ravassa S, Lopez B, López N et al. Cardiomyocyte apoptosis in hypertensive cardiomyopathy. Cardiovasc Res 2003;59:549-562.
18. Colucci WS, Braunwald E. Pathophysiology of heart failure. In: Braunwald E, Zipes DP, Libby P (eds) Heart Disease. Philadelphia: WB Saunders; 2001. pp. 503-533.
19. Communal C, Sumandea M, de Tombe P, Narula J, Solaro RJ, Hajjar RJ. Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci USA 2002;99:6252-6256.
20. Laugwitz KL, Moretti A, Weig HJ, Gillitzer A, Pinkernell K, Ott T et al. Blocking caspase-activated apoptosis improves contractility in failing myocardium. Hum Gene Ther 2001;12:2051-2063.
21. Narula J, Arbustini E, Chandrashekhar Y, Schwaiger M. Apoptosis and the systolic dysfunction in congestive heart failure. Story of apoptosis interruptus and zombie myocytes. Cardiol Clin 2001;19:113-126.
22. Narula J, Kolodgie FD, Virmani R. Apoptosis and cardiomyopathy. Curr Opin Cardiol 2000;15:183-188.