Altered vasodilator role of nitric oxide synthase in the pancreas, heart and brain of rats with spontaneous type 2 diabetes

European Journal of Pharmacology

Volumn 591, Issue 1-3, 2008, Pages 177-181

  Song, Dongzhe ^a   Yao, Reina ^a   Pang, Catherine C Y ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

1400W; Blood flow; Cardiac output; Diabetes mellitus; iNOS; l NAME

Indexed keywords

CONSTITUTIVE NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MICROSPHERE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; THIOBUTABARBITAL; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN FUNCTION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENZYME INHIBITION; ENZYME SPECIFICITY; HEART FUNCTION; HEART OUTPUT; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS BLOOD FLOW; PANCREAS FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASCULAR RESISTANCE; VASOCONSTRICTION; VASODILATATION; ZUCKER DIABETIC FATTY RAT;

ANIMALS; BLOOD PRESSURE; BRAIN; CARDIAC OUTPUT; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; HEART RATE; MALE; MYOCARDIUM; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PANCREAS; RATS; RATS, ZUCKER;

EID: 48749097038     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.036     Document Type: Article

References (37)

1. Bardell A.L., and MacLeod K.M. Evidence for inducible nitric-oxide synthase expression and activity in vascular smooth muscle of streptozotocin-diabetic rats. J. Pharmacol. Exp. Ther. 296 (2001) 252-259
2. Cheng X., Cheng X.S., Kuo K.H., and Pang C.C.Y. Inhibition of iNOS augments cardiovascular action of noradrenaline in streptozotocin-induced diabetes. Cardiovasc. Res. 64 (2004) 298-307
3. Considine R.V. Human leptin: an adipocyte hormone with weight-regulatory and endocrine functions. Semin. Vasc. Med. 5 (2005) 15-24
4. Erdely A., Freshour G., Maddox D.A., Olson J.L., Samsell L., and Baylis C. Renal disease in rats with type 2 diabetes is associated with decreased renal nitric oxide production. Diabetologia 47 (2004) 1672-1676
5. Fedorak R.N. Adaptation of small intestinal membrane transport processes during diabetes mellitus in rats. Can. J. Physiol. Pharm. 68 (1990) 630-635
6. Fredersdorf S., Thumann C., Ulucan C., Griese D.P., Luchner A., Riegger G.A., Kromer E.P., and Weil J. Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats. Cardiovasc. Pathol. 13 (2004) 11-19
7. Fujita Y., Kojima H., Hidaka H., Fujimiya M., Kashiwagi A., and Kikkawa R. Increased intestinal glucose absorption and postprandial hyperglycaemia at the early step of glucose intolerance in Otsuka Long-Evans Tokushima Fatty rats. Diabetologia 41 (1998) 1459-1466
8. Griffen S.C., Wang J., and German M.S. A genetic defect in beta-cell gene expression segregates independently from the fa locus in the ZDF rat. Diabetes 50 (2001) 63-68
9. Gronbaek H., Nielsen B., Frystyk J., Orskov H., and Flyvbjerg A. Effect of octreotide on experimental diabetic renal and glomerular growth: importance of early intervention. J. Endocrinol. 147 (1995) 95-102
10. Hilzenrat N., Sikuler E., Yaari A., and Maislos M. Hemodynamic characterization of the diabetic Psammomys obesus- an animal model of type II diabetes mellitus. Isr. J. Med. Sci. 32 (1996) 1074-1078
11. Hirose H., Lee Y.H., Inman L.R., Nagasawa Y., Johnson J.H., and Unger R.H. Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes. J. Biol. Chem. 271 (1996) 5633-5637
12. Hudetz A.G., Shen H., and Kampine J.P. Nitric oxide from neuronal NOS plays critical role in cerebral capillary flow response to hypoxia. Am. J. Physiol. 274 (1998) H982-H989
13. Iwase M., Uchizono Y., Tashiro K., Goto D., and Iida M. Islet hyperperfusion during prediabetic phase in OLETF rats, a model of type 2 diabetes. Diabetes 51 (2002) 2530-2535
14. Kelly P.A., Ritchie I.M., and McBean D.E. 7-nitroindazole reduces cerebral blood flow following chronic nitric oxide synthase inhibition. Brain Res. 885 (2000) 295-297
15. Kobayashi T., Matsumoto T., Ooishi K., and Kamata K. Differential expression of alpha2D-adrenoceptor and eNOS in aortas from early and later stages of diabetes in Goto-Kakizaki rats. Am. J. Physiol. Heart Circ. Physiol. 287 (2004) H135-H143
16. Lautt W.W. Control of hepatic arterial blood flow: independence from liver metabolic activity. Am. J. Physiol. 239 (1980) H559-H564
17. Lee Y., Hirose H., Ohneda M., Johnson J.H., McGarry J.D., and Unger R.H. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 10878-10882
18. Lesniewski L.A., Donato A.J., Behnke B.J., Woodman C.R., Laughlin M.H., Ray C.A., and Delp M.D. Decreased no signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension. Am. J. Physiol. 294 (2008) H1840-1850
19. G-nitro-L-arginine methyl ester in rats with monocrotaline-induced pulmonary hypertension. Pharmacology 69 (2003) 164-170
20. McMillan D.E. Development of vascular complications in diabetes. Vasc. Med. 2 (1997) 132-142
21. Nagareddy P.R., Xia Z., McNeill J.H., and MacLeod K.M. Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes. Am. J. Physiol. Heart Circ. Physiol. 289 (2005) H2144-2H152
22. Okon E.B., Chung A.W., Rauniyar P., Padilla E., Tejerina T., McManus B.M., Luo H., and van Breemen C. Compromised arterial function in human type 2 diabetic patients. Diabetes 54 (2005) 2415-2423
23. Pang C.C.Y. Effect of vasopressin antagonist and saralasin on regional blood flow following hemorrhage. Am. J. Physiol. 245 (1983) H749-H755
24. Peterson R.G., Shaw W.N., Neel M., Little L.A., and Eichberg J. New rat models of obesity and type II diabetes. ILAR J. 32 (1990) 16-19
25. Price S.R., Bailey J.L., Wang X., Jurkovitz C., England B.K., Ding X., Phillips L.S., and Mitch W.E. Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription. J. Clin Invest. 98 (1996) 1703-1708
26. Schwaninger R.M., Sun H., and Mayhan W.G. Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats. Life Sci. 73 (2003) 3415-3425
27. Smith J.M., Paulson D.J., and Romano F.D. Inhibition of nitric oxide synthase by L-NAME improves ventricular performance in streptozotocin-diabetic rats. J. Mol. Cell. Cardiol. 29 (1997) 2393-2402
28. Song D., Kuo K.H., Yao R., Hutchings S.R., and Pang C.C.Y. Inducible nitric oxide synthase depresses cardiac contractile function in Zucker diabetic fatty rats. Eur. J. Pharmacol. 579 (2007) 253-259
29. Staunton M., Drexler C., Schmid III P.G., Havlik H.S., Hudetz A.G., and Farber N.E. Neuronal nitric oxide synthase mediates halothane-induced cerebral microvascular dilation. Anesthesiology 92 (2000) 125-132
30. Svensson A.M., Ostenson C.G., Efendic S., and Jansson L. Effects of glucagon-like peptide-1-(7-36)-amide on pancreatic islet and intestinal blood perfusion in Wistar rats and diabetic GK rats. Clin. Sci. 112 (2007) 345-351
31. Uriu K., Kaizu K., Qie Y.L., Kai K., Ito A., Ikeda M., Hashimoto O., Sun X.F., Morita E., and Eto S. Renal hemodynamics in Otsuka Long-Evans Tokushima fatty rat, a model rat of spontaneous non-insulin-dependent diabetes mellitus with obesity. J. Lab. Clin. Med. 134 (1999) 483-491
32. Van den Bergh A., Flameng W., and Herijgers P. Type II diabetic mice exhibit contractile dysfunction but maintain cardiac output by favourable loading conditions. Eur. J. Heart Fail. 8 (2006) 777-783
33. G-nitro-L-arginine by halothane. J. Cardiovasc. Pharmacol. 22 (1993) 571-578
34. Wang P., and Chatham J.C. Onset of diabetes in Zucker diabetic fatty (ZDF) rats leads to improved recovery of function after ischemia in the isolated perfused heart. Am. J. Physiol. 286 (2004) E725-736
35. WHO, 2000. http://www.who.int/diabetes/facts/world_figures/en/
36. Yamagishi S., and Imaizumi T. Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy. Curr. Pharm. 11 (2005) 2279-2299
37. Zhou Y.T., Graybur P., Karim A., Shimabukuro M., Higa M., Baetens D., Orci L., and Unger R.H. Lipotoxic heart disease in obese rats: implications for human obesity. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 1784-1789