Controlled delivery of anti-sense oligodeoxynucleotide from multilayered biocompatible phosphorylcholine polymer films

Journal of Controlled Release

Volumn 130, Issue 1, 2008, Pages 69-76

  Zhang, Zhuoqi ^a   Cao, Xichuan ^a   Zhao, Xiubo ^a   Holt, Cathy M ^b   Lewis, Andrew L ^c   Lu, Jian R ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c BIOCOMPATIBLES UK LTD   (United Kingdom)

Author keywords

Antisense oligodeoxynucleotide; Cell growth inhibition; Controlled release; Multilayer films; PC polymer

Indexed keywords

CELL GROWTH; CELLS; CHARGE DENSITY; CLADDING (COATING); COLLOIDS; CONFOCAL MICROSCOPY; COPOLYMERIZATION; ELECTROCHEMISTRY; ELECTROPHORESIS; ENERGY ABSORPTION; FILM GROWTH; GELATION; GELS; GENE TRANSFER; GROWTH KINETICS; IMAGING TECHNIQUES; MICROSCOPIC EXAMINATION; MOLECULAR BEAM EPITAXY; MULTILAYER FILMS; NUCLEIC ACIDS; OPTICAL DESIGN; ORGANIC ACIDS; PLASTIC FILMS; PLASTIC PRODUCTS; POLYMERS; PULSED LASER DEPOSITION; RELIABILITY; SELF ASSEMBLY; SPECTROSCOPIC ELLIPSOMETRY;

ANTISENSE (AS); BI-LAYERS; BIOLOGICAL EFFECTS; CELL GROWTH INHIBITION; CELLULAR UPTAKE; CONFOCAL LASER SCANNING MICRO SCOPY (CLSM); CONTROLLED LOADING; CONTROLLED-DELIVERY; DNA INTEGRITY; ELECTROSTATIC SELF-ASSEMBLY (ESA); ELUTION PROFILES; FLUORESCENT MICROSCOPY; GEL ELECTROPHORESIS (GE); GENE DELIVERY; HELA CELLS; KINETIC (POLYM.); LOADING CAPACITIES; MULTI LAYER PROCESSING; MULTI-LAYERED; MULTI-LAYERED FILMS; OLIGODEOXYNUCLEOTIDE (ODN); PHOSPHORYLCHOLINE (PC); PHYSIOLOGICAL CONDITIONS; POLYANIONS (PA); POLYCATIONS (PC); PROMISING APPROACH; RELEASE MECHANISM; SINGLE LAYERS; SLOW RELEASES; SPECTROSCOPIC ELLIPSOMETRY (SE); TRANSGENIC; UV SPECTROMETRY; ZERO ORDER KINETICS;

POLYMER FILMS;

ANTISENSE OLIGONUCLEOTIDE; PHOSPHORYLCHOLINE; POLYMER;

ARTICLE; BIOCOMPATIBILITY; CELL GROWTH; CHEMICAL STRUCTURE; CONFOCAL LASER MICROSCOPY; DRUG DELIVERY SYSTEM; ELLIPSOMETRY; ELUTION; FILM; FILM COATING; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

BIOCOMPATIBLE MATERIALS; CELL PROLIFERATION; DRUG CARRIERS; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PHOSPHORYLCHOLINE; POLYMERS; TRANSFECTION;

EID: 48749090985     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.05.011     Document Type: Article

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