Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma

Modern Pathology

Volumn 21, Issue 8, 2008, Pages 992-1001

  Kamiya, Kazunori ^a   Hayashi, Yuichiro ^a   Douguchi, Junya ^a   Hashiguchi, Akinori ^a   Yamada, Taketo ^a   Izumi, Yotaro ^a   Watanabe, Masazumi ^a   Kawamura, Masafumi ^a   Horinouchi, Hirohisa ^a   Shimada, Naoki ^a   Kobayashi, Koichi ^a   Sakamoto, Michiie ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Electron microscopy; Histopathology; Immunohistochemistry; Lung adenocarcinoma; Micropapillary pattern; Prognosis

Indexed keywords

BETA CATENIN; CD34 ANTIBODY; KI 67 ANTIGEN; LAMININ; UVOMORULIN;

ADULT; AGED; ARTICLE; BASEMENT MEMBRANE; CELL JUNCTION; CLINICAL FEATURE; ELECTRON MICROSCOPY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROPAPILLARY PATTERN; OVERALL SURVIVAL; PLEURA METASTASIS; PRIORITY JOURNAL; PROGNOSIS;

ADENOCARCINOMA, PAPILLARY; ADULT; AGED; AGED, 80 AND OVER; BASEMENT MEMBRANE; BETA CATENIN; CADHERINS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; KI-67 ANTIGEN; LAMININ; LUNG NEOPLASMS; LYMPH NODES; MALE; MIDDLE AGED; NEOPLASM STAGING; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 48749085123     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2008.79     Document Type: Article

References (24)

1. Alberg AJ, Samet JM. Epidemiology of lung cancer. Chest 2003;123(1 Suppl):21S-49S.
2. Jemal A, Siegal R, Ward E, et al. Cancer statistics. CA Cancer J Clin 2006;56:10-30.
3. Travis WD, Brambilla E, Muller-Hermelink HK, et al. World Health Organization Classification of Tumors: Pathology and Genetics of Tumours of Lung, Pleura, Thymus and Heart. IARC Press: Lyon, 2004, pp 26-34.
4. Noguchi M, Morikawa A, Kawasaki M, et al. Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer 1995;75:2844-2852.
5. Sobin LH, Wittenkind CH, (eds). TNM Classification of Malignant Tumours, 6th edn. Wiley-Liss: New York, 2002.
6. Beadsmoore CJ, Screaton NJ. Classification, staging and prognosis of lung cancer. Eur J Radiol 2003;45:8-17.
7. Goya T, Asamura H, Yoshimura H, et al. Prognosis of 6644 resected non-small cell lung cancers in Japan: a Japanese Lung Cancer Registry Study. Lung Cancer 2005;50:227-234.
8. Kawai H, Tada A, Kawahara M, et al. Smoking history before surgery and prognosis in patients with stageIA non-small-cell lung cancer-a multicenter study. Lung Cancer 2005;49:63-67.
9. Sakao Y, Tomimitsu S, Takeda Y, et al. Carcinoembryonic antigen as a predictive factor for postoperative tumor relapse in early-stage lung adenocarcinoma. Eur J Cardiothorac Surg 2004;25:520-522.
10. Gajra A, Newman N, Gamble GP, et al. Impact of tumor size on survival in stageIA non-small cell lung cancer: a case for subdividing stageIA disease. Lung Cancer 2003;42:51-57.
11. Goldstein NS, Mani A, Chmielewski G, et al. Prognostic factors in T1 N0 M0 adenocarcinomas and bronchioloalveolar carcinomas of the lung. Am J Clin Pathol 1999;112:391-402.
12. Suzuki K, Nagai K, Yoshida J, et al. Predictors of lymph node and intrapulmonary metastasis in clinical stage-IA non-small cell lung carcinoma. Ann Thorac Surg 2001;72:352-356.
13. Luna-More S, Gonzalez B, Acedo C, et al. Invasive micropapillary carcinoma of the breast. A new special type of invasive mammary carcinoma. Pathol Res Pract 1994;190:668-674.
14. Sakamoto K, Watanabe M, De La Cruz C, et al. Primary invasive micropapillary carcinoma of the colon. Histopathology 2005;47:479-484.
15. Perez-Montiel D, Hes O, Michal M, et al. Micropapillary urothelial carcinoma of the upper urinary tract: clinicopathological study of 25 cases. Am J Clin Pathol 2006;126:86-92.
16. Bell KA, Smith Sehdev AE, Kurman RJ, et al. Refined diagnostic criteria for implants associated with ovarian atypical proliferative serous tumors (borderline) and micropapillary serous carcinomas. Am J Surg Pathol 2001;25:419-432.
17. Nagao T, Gaffy TA, Visscher DW, et al. Invasive salivary duct carcinoma. A distinct histologic variant with biologic significance. Am J Surg Pathol 2004;228:319-326.
18. Amin MB, Tamboli P, Merchant SH, et al. Micropapillary component in lung adenocarcinoma: a distinctive histologic feature with possible prognostic significance. Am J Surg Patho 2002;26:358-364.
19. Miyoshi T, Satoh Y, Okumura S, et al. Early-stage lung adenocarcinomas with a micropapillary pattern, a distinct pathologic marker for a significantly poor prognosis. Am J Surg Patho 2003;27:101-109.
20. Tsutsumida H, Nomoto M, Goto M, et al. A micropapillary pattern is predictive of a poor prognosis in lung adenocarcinoma, and reduced surfactant apoprotein A expression in the micropapillary pattern is an excellent indicator of a poor prognosis. Mod Pathol 2007;20:638-647.
21. Makimoto Y, Nabeshima K, Iwasaki H, et al. Micropapillary pattern: a distinct pathological marker to subclassify tumours with a significantly poor prognosis within small peripheral lung adenocarcinoma (≤20mm) with mixed bronchioloalveolar and invasive subtypes (Noguchi's type C tumours). Histopathology 2005;46:677-684.
22. Igaki T, Pagliarini RA, Xu T. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol 2006;16:1139-1146.
23. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994;124:619-626.
24. Frisch SM, Ruoslahti E. Integrins and anoikis. Cur Opin Cell Biol 1997;9:701-706.