Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors

FASEB Journal

Volumn 22, Issue 8, 2008, Pages 3068-3077

  Gembardt, Florian ^a,b   Heringer Walther, Silvia ^a   Van Esch, Joep H M ^b   Sterner Kock, Anja ^c   Van Veghel, Richard ^b   Le, Thu H ^d   Garrelds, Ingrid M ^b   Coffman, Thomas M ^d   Jan Danser, A H ^b   Schultheiss, Heinz Peter ^a   Walther, Thomas ^a,e  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF HULL   (United Kingdom)

Author keywords

Hemodynamics; Receptor genes; Transgenic mice; Transmembrane spanning receptors

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR TYPE 1; ANGIOTENSIN 2 RECEPTOR TYPE 2;

ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; GENE DELETION; HEART HEMODYNAMICS; HEART RATE; HISTOPATHOLOGY; HYPOTENSION; KIDNEY DEVELOPMENT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SURVIVAL; VASOCONSTRICTION;

ANGIOTENSIN II; ANIMALS; BASE SEQUENCE; BLOOD PRESSURE; DNA PRIMERS; HEART RATE; KIDNEY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RENIN-ANGIOTENSIN SYSTEM; VASOCONSTRICTION;

MUS; MUS MUSCULUS; RODENTIA;

EID: 48749084093     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.08-108316     Document Type: Article

References (39)

1. Timmermans, P. B., Wong, P. C., Chiu, A. T., Herblin, W. F., Benfield, P., Carini, D. J., Lee, R. J., Wexler, R. R., Saye, J. A., and Smith, R. D. (1993) Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol. Rev. 45, 205-251
2. Iwai, N., Inagami, T., Ohmichi, N., Nakamura, Y., Saeki, Y., and Kinoshita, M. (1992) Differential regulation of rat AT1a and AT1b receptor mRNA. Biochem. Biophys. Res. Commun. 188, 298-303
3. Burson, J. M., Aguilera, G., Gross, K. W., and Sigmund, C. D. (1994) Differential expression of angiotensin receptor 1A and 1B in mouse. Am. J. Physiol. 267, E260-E267
4. Gasc, J. M., Shanmugam, S., Sibony, M., and Corvol, P. (1994) Tissue-specific expression of type 1 angiotensin II receptor subtypes: an in situ hybridization study. Hypertension 24, 531-537
5. Steckelings, U. M., Kaschina, E., and Unger, T. (2005) The AT2 receptor - a matter of love and hate. Peptides 26, 1401-1409
6. Grady, E. F., Sechi, L. A., Griffin, C. A., Schambelan, M., and Kalinyak, J. E. (1991) Expression of AT2 receptors in the developing rat fetus. J. Clin. Invest. 88, 921-933
7. 2) receptor mRNA in the rat. Kidney Int. 47, 1095-1100
8. Ito, M., Oliverio, M. I., Mannon, P. J., Best, C. F., Maeda, N., Smithies, O., and Coffman, T. M. (1995) Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc. Natl. Acad. Sci. U. S. A. 92, 3521-3525
9. 1B receptors for angiotensin II. Proc. Natl. Acad. Sci. U. S. A. 95, 15496-15501
10. Ichiki, T., Labosky, P. A., Shiota, C., Okuyama, S., Imagawa, Y., Fogo, A., Niimura, F., Ichikawa, I., Hogan, B. L., and Inagami, T. (1995) Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 377, 748-750
11. 1A receptor activation. Br. J. Pharmacol. 148, 452-458
12. Niimura, F., Labosky, P. A., Kakuchi, J., Okubo, S., Yoshida, H., Oikawa, T., Ichiki, T., Naftilan, A. J., Fogo, A., and Inagami, T. (1995) Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J. Clin. Invest. 96, 2947-2954
13. Krege, J. H., John, S. W., Langenbach, L. L., Hodgin, J. B., Hagaman, J. R., Bachman, E. S., Jennette, J. C., O'Brien, D. A., and Smithies, O. (1995) Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 375, 146-148
14. Tanimoto, K., Sugiyama, F., Goto, Y., Ishida, J., Takimoto, E., Yagami, K., Fukamizu, A., and Murakami, K. (1994) Angiotensinogen-deficient mice with hypotension. J. Biol. Chem. 269, 31334-31337
15. 2 receptor leads to increased cell numbers in different brain structures of mice. Regul. Pept. 99, 209-216
16. Walther, T., Steendijk, P., Westermann, D., Hohmann, C., Schulze, K., Heringer-Walther, S., Schultheiss, H. P., and Tschope, C. (2004) Angiotensin deficiency in mice leads to dilated cardiomyopathy. Eur. J. Pharmacol. 493, 161-165
17. Walther, T., Tschope, C., Sterner-Kock, A., Westermann, D., Heringer-Walther, S., Riad, A., Nikolic, A., Wang, Y., Ebermann, L., Siems, W. E., Bader, M., Shakibaei, M., Schultheiss, H. P., and Dorner, A. (2007) Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease. Circulation 115, 333-344
18. 2 receptor. Kidney Int. 57, 191-202
19. Gembardt, F., Sterner-Kock, A., Imboden, H., Spalteholz, M., Reibitz, F., Schultheiss, H. P., Siems, W. E., and Walther, T. (2005) Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents. Peptides 26, 1270-1277
20. Alexiou, T., Boon, W. M., Denton, D. A., Nicolantonio, R. D., Walker, L. L., McKinley, M. J., and Campbell, D. J. (2005) Angiotensinogen and angiotensin-converting enzyme gene copy number and angiotensin and bradykinin peptide levels in mice. J. Hypertens. 23, 945-954
21. Danser, A. H., van Kats, J. P., Admiraal, P. J., Derkx, F. H., Lamers, J. M., Verdouw, P. D., Saxena, P. R., and Schalekamp, M. A. (1994) Cardiac renin and angiotensins: uptake from plasma versus in situ synthesis. Hypertension 24, 37-48
22. 2) angiotensin receptor. Proc. Natl. Acad. Sci. U. S. A. 96, 6506-6510
23. Konstam, M. A., Neaton, J. D., Poole-Wilson, P. A., Pitt, B., Segal, R., Sharma, D., Dasbach, E. J., Carides, G. W., Dickstein, K., Riegger, G., Camm, A. J., Martinez, F. A., Bradstreet, D. C., Ikeda, L. S., and Santoro, E. P. (2005) Comparison of losartan and captopril on heart failure-related outcomes and symptoms from the losartan heart failure survival study (ELITE II). Am. Heart J. 150, 123-131
24. Dendorfer, A., Dominiak, P., and Schunkert, H. (2005) ACE inhibitors and angiotensin II receptor antagonists. Handb. Exp. Pharmacol. 407-442
25. Schmieder, R. E., Hilgers, K. F., Schlaich, M. P., and Schmidt, B. M. (2007) Renin-angiotensin system and cardiovascular risk. Lancet 369, 1208-1219
26. Tokuyama, H., Kelly, D. J., Zhang, Y., Gow, R. M., and Gilbert, R. E. (2007) Macrophage infiltration and cellular proliferation in the non-ischemic kidney and heart following prolonged unilateral renal ischemia. Nephron 106, p54-62
27. i coupling causes hypertrophy and bradycardia in transgenic mice. J. Clin. Invest. 115, 3045-3056
28. 1 receptor antagonist. J. Biol. Chem. 276, 39721-39726
29. 1 receptors through a nitric oxide- and RhoA-dependent mechanism resulting in decreased phospholipase D activity. Am. J. Physiol. 288, F763-F770
30. 1 receptors and control of blood pressure: the kidney and more. Trends Cardiovasc. Med. 17, 30-34
31. Li, Q., Zhang, J., Pfaffendorf, M., and van Zwieten, P. A. (1996) Direct positive chronotropic effects of angiotensin II and angiotensin III in pithed rats and in rat isolated atria. Br. J. Pharmacol. 118, 1653-1658
32. McEwan, P. E., Sherry, L., Kenyon, C. J., Webb, D. J., and Gray, G. A. (2000) Regulation of the myocardial endothelin system by angiotensin-II and losartan. J. Cardiovasc. Pharmacol. 36, S144-S147
33. 1B double-knockout mice. Am. J. Physiol. 289, F902-F910
34. Batenburg, W. W., van Esch, J. H., Garrelds, I. M., Jorde, U., Lamers, J. M., Dekkers, D. H., Walther, T., Kellett, E., Milligan, G., van Kats, J. P., and Danser, A. H. (2006) Carvedilol-induced antagonism of angiotensin II: a matter of alpha1-adrenoceptor blockade. J. Hypertens. 24, 1355-1363
35. Dendorfer, A., Raasch, W., Tempel, K., and Dominiak, P. (1998) Interactions between the renin-angiotensin system (RAS) and the sympathetic system. Basic Res. Cardiol. 93(Suppl. 2), 24-29
36. Kihara, M., Umemura, S., Sumida, Y., Yokoyama, N., Yabana, M., Nyui, N., Tamura, K., Murakami, K., Fukamizu, A., and Ishii, M. (1998) Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice. Kidney Int. 53, 548-555
37. Miyazaki, Y., and Ichikawa, I. (2001) Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract. Comp. Biochem. Physiol. 128, 89-97
38. Nishimura, H., Yerkes, E., Hohenfellner, K., Miyazaki, Y., Ma, J., Hunley, T. E., Yoshida, H., Ichiki, T., Threadgill, D., Phillips, J. A. 3rd, Hogan, B. M., Fogo, A., Brock, J. W. 3rd, Inagami, T., and Ichikawa, I. (1999) Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol. Cell 3, 1-10
39. Reid, J. L. (2005) Molecular-specific effects of angiotensin II antagonists: clinical relevance to treating hypertension? J. Renin Angiotensin Aldosterone Syst. 6, 15-24