Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4503-4507

  Regan, Colin F ^a   Guo, Zhiqiang ^a   Chen, Yongsheng ^a   Huang, Charles Q ^a   Chen, Mi ^a   Jiang, Wanlong ^a   Rueter, Jaimie K ^a   Coon, Timothy ^a   Chen, Chen ^a   Saunders, John ^a   Brown, Michael S ^a   Betz, Steve F ^a   Struthers, R Scott ^a   Yang, Chun ^a   Wen, Jenny ^a   Madan, Ajay ^a   Zhu, Yun Fei ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

Antagonist; CYP3A4; Gonadotropin releasing hormone; Non peptide; Uracil; Zwitterions

Indexed keywords

AMPHOLYTE; CYTOCHROME P450 3A4; GONADORELIN ANTAGONIST; URACIL DERIVATIVE;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

CHEMISTRY, PHARMACEUTICAL; CYTOCHROME P-450 CYP3A; DRUG DESIGN; GONADOTROPIN-RELEASING HORMONE; HUMANS; IONS; KINETICS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PEPTIDES; RECEPTORS, LHRH; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL;

EID: 48649095505     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.059     Document Type: Article

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9. The reagent was prepared according to the following scheme:{A figure is presented}.